Lipid peroxidation and antioxidant system in menopausal women with insomnia
https://doi.org/10.12737/article_590823a46a7b46.99413563
Abstract
According to the current data, most menopausal women have reduced life quality and one of the main criteria is sleep quality. It is well known, that sleep loss may cause oxidative stress. The aim of this study was to assess lipid peroxidation and antioxidant system in postmenopausal women with insomnia. Materials and methods: 41 postmenopausal women (18 patients with insomnia, 23 women without insomnia (control)) were examined. Sleep disorders were assessed by using sleep questionnaire (Stanford Sleep Research Center, USA), Epworth Sleepiness Scale, Insomnia Severity Index. The materials for biochemical studies were blood plasma and red cells. Lipid peroxidation and antioxidant system parameters by spectrophotometric and fluorometric methods were determined. Statistical analysis was performed by non-parametric test. The study results showed increase primary products levels in patients with insomnia compared with the control group. Main and control group antioxidant system parameters have no differences. Oxidative stress coefficient in group with insomnia higher than control. Conclusions: insomnia in postmenopausal women is associated with the development of oxidative stress.
About the Author
N. V. Semyonova
Scientific Centre for Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
References
1. Колесникова Л.И., Гребёнкина Л.А., Долгих B.B., Натяганова Л.В., Осипова E.B., Старостенко O.B. Особенности процессов липопероксидации у подростков с эссенциальной артериальной гипертензией c помощью интегрального показателя // Клиническая лабораторная диагностика. - 2012. - № 6. - C. 29-31
2. Колесникова Л.И., Мадаева И.М., Семёнова H.B., Сутурина Л.В., Бердина O.H., Шолохов Л.Ф., Солодова Е.И. Патогенетическая роль мелатонина при нарушениях сна у жєнщин климактерического периода // Бюллетень экспериментальной Биологии и медицины. - 2013. - № ï57 (7). - C. 117-119.
3. Колесникова Л.И., Осипова E.B., Гребёнкина Л.А. Окислительный стресс при репродуктивных нарушениях эндокринного генеза у женщин. - Новосибирск, 2011. - їїб с
4. Мадаева И.М., Петрова B.A., Колесникова Л.И., Шевырталова O.H. Синдром обструктивного апноэ/ гипопноэ сна и перекиеное окисление липидов // Пульмонология. - 2009. - № 2. - C. 65-69
5. Меньщикова Е.Б., Зенков Н.К., Ланкин В.З., Бондарь И.А., Труфакин B.A. Окислительный стресе: Патологические состояния и заболевания. - Новосибирск: APTA, 2008. - 284 с
6. Протопопова H.B., Колесникова Л.И., Ильин В.П. Метаболизм и гемодинамика у беременных е артериальной гипертензией. - Новосибирск, 2000. - 260 с
7. Колесникова Л.И., Сутурина Л.В., Лабыгина A.B., Лещенко О.Я., Фёдоров Б.А., Шолохов Л.Ф. Нарушения репродуктивного здоровья и репродуктивного потенциала в современных условиях Восточной Сибири // Бюллетень ВСНЦ CO РАМН. - 2007. - № 2. - C. 41-43
8. Baysal Е, Taysi S, Aksoy N, Uyar M, Celenk Е, Karatas ZA (2012). Serum paraoxonase, arylesteraseactivity and oxidative status in patients with obstructive sleep apnea syndrome (OSAS). Eur. Rev. Med. Pharmacol. Sci., (16), 770-774
9. Gulec M, Ozkol H, Selvi Y, Tuluce Y, Aydin А, Besiroglu L et al. (2012). Oxidative stress in patients with primary insomnia. Prog. Neuropsychopharmacol Biol. Rsychiatry., 37 (2), 247-251.
10. Hachul DE, Campos H, Brandao LC, D’Almeida V, Grego ВН, Bittencourt LR et al. (2006). Sleep disturbances, oxidative stress and cardiovascular risk parameters in postmenopausal women complaining of insomnia. Climacteric, (9), 312-319.
11. Kalleinen N (2008). Sleep and menopause - hormone therapy and sleep deprivation. Painosalama Oy, 78.
12. Kolesnikova L, Madaeva І, Semenova N, Vlasov В, Grebenkina L, Darenskaya M (2013). Antioxidant potential of the blood in men with obstructive sleep breathing disorders. Bulletin of Experimental Biology and Medicine, ï54 (6), 731-733.
13. Lee WL, Huang JY, Shyur LF (2013). Phytoagents for cancer management: regulation of nucleic acid oxidation, ROS, and related mechanisms. Oxidative Medicine and Cellular Longevity, (925804), 1-22.
14. Liang В, Li Y-H, Kong H (2013). Serum paraoxonase, arylesterase activities and oxidative status in patients with insomnia. Eur. Rev. Med. Pharmacol. Sci., (17), 25ï7-2522.
15. Mendoza-Nunez VM, Beristain-Perez А, Реrez-Vera SP, Altamirano-Lozano MA (2010). Age-related sex differences in glutathione peroxidase and oxidative DNA damage in a healthy Mexican population.J. Women's Health, 19 (5), 919-926.
16. Ogunro PS, Bolarinde АА, Owa OO, Salawu АА, Oshodi АА (2014). Antioxidant status and reproductive hormones in women during reproductive, perimenopausal and postmenopausal phase of life. Afr. J. Med. Sci., 43 (1), 49-57.
17. Reimund Е (1994). The free radical flux theory of sleep. Med. Hypotheses, (43), 231-233.
18. Sanchez-Rodriguez MA, Zacarias-Flores M, Arronte-Rosales А, Correa-Muno Е, Mendoza-Nunez VM (2012). Menopause as risk factor for oxidative stress. Menopause, 19 (3), 361-367.
Review
For citations:
Semyonova N.V. Lipid peroxidation and antioxidant system in menopausal women with insomnia. Acta Biomedica Scientifica. 2016;1(3(2)):74-77. (In Russ.) https://doi.org/10.12737/article_590823a46a7b46.99413563
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