Peculiarities of the antioxidant status of adolescents with arterial hypertension

Abstract

One of the most topical problems in the field of healthcare is to solve the issues of an early diagnosis, timely prevention and effective treatment of cardiovascular diseases, which include arterial hypertension (the AH]. Prevalence of EAH in the pediatric population in Russia amounts to 20 %. Despite the fact that the mechanisms of the disease were studied in detail, metabolic changes that led to its early deve^ment in teenagers were still not entirely clear. In the Clinic of FSBSI Scientific Center for Family Health Problems and Human Reproduction (Irkutsk], clinical and functional examination of 48 male adolescents aged 14-17 years, of which 25 patients with stable arterial hypertension and 23 adolescents without somatic pathology with normal blood pressure, was conducted. Antioxidant status was studied in blood plasma and hemolysate. A comparative analysis of the following indicators was conducted: total antioxidant activity, superoxide dismutase activity, level of retinol and α-tocopherol, glutathione system parameters. Patients with stable arterial hypertension were recorded with level of overall antioxidant activity in blood 29 % higher than the benchmark, decreased superoxide dismutase activity by 11 % and content of а-tocopherol by 44 %. Retinol concentration in teenagers with hypertension was two times higher than the content of this indicator in the control group (р = 0.00]. Decrease in the antioxidant levels was found in adolescents with arterial hypertension that can be the cause of the oxidative stress development.