Apolipoprotein-b gen and its role in formation of essential hypertension
Abstract
For two groups of Russian teenagers the proportion of deletion (Del) allele of the apolipoprotein-B gene polymorphism (ApoB, Ins/Del, rs17240441) was studied. One group of 70 teenagers with essential hypertension, and the comparison group - 73 healthy teenagers. In both groups, the most common genotype was heterozygous genotype Ins/Del, in the group with essential hypertension it was 67,1 %, in the control group - 52,1 %. The frequency of Del allele in the group with essential hypertension was 47,9 %, which was significantly higher than in the comparison group - 30,1 % (p = 0,003). Thus, the high frequency of deletion allele in the studied group with hypertension indicates an increased risk of cardiovascular disease in this group in the future and has prognostic significance.
About the Authors
L. I. Kolesnikova
Scientific Centre for the Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
O. V. Kalyuzhnaya
Scientific Centre for the Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
L. V. Rychkova
Scientific Centre for the Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
A. S. Kosovtseva
Scientific Centre for the Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
O. A. Yershova
Scientific Centre for the Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
T. V. Mandzyak
Scientific Centre for the Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
T. A. Bairova
Scientific Centre for the Family Health and Human Reproduction Problems
Russian Federation
Russian Federation
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Review
For citations:
Kolesnikova L.I., Kalyuzhnaya O.V., Rychkova L.V., Kosovtseva A.S., Yershova O.A., Mandzyak T.V., Bairova T.A. Apolipoprotein-b gen and its role in formation of essential hypertension. Acta Biomedica Scientifica. 2015;(6):58-61. (In Russ.)
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