CLOSTRIDIUM DIFFICILE ASSOCIATED DIARRHEA IN MULTIDISCIPLINARY HOSPITAL
Abstract
Currently, Clostridium difficile is the main reason of a nosocomial diarrhea, caused by uncontrolled antibacterial treatment. This problem is not paid, enough attention in our country. We analyzed. 536 cases of antibiotic associated infections using new immunochromotographical assay for express detection of Clostridium difficile. Since 2008 to 2011 evaluated rate of the positive tests was 28,7 % among the hospital patients. The first line therapy of this infection is vancomycine and metronidazole. We also observed increased incidence of mycosis, which accompanying the antibiotic associated diarrheas. During the same period the rate of Candida spp. infection was 50,8 % among the same patients. We used fluconazole and. amphotericine for the mycosis treatment. We also recommended to manage disbiosis during one year after discontinue of the treatment, and. we supposed reasonable to be managed by infectionist for this group of patients.
About the Authors
N. F. Mulyar
Irkutsk Regional clinical hospital
Russian Federation
Russian Federation
S. A. Vereschagina
Irkutsk Regional clinical hospital; Irkutsk Regional Pathology Department
Russian Federation
Russian Federation
T. V. Fadeeva
Scientific Centre of Reconstructive and Restorative Surgery, Siberian Branch of RAMS
Russian Federation
Russian Federation
G. P. Spasov
Irkutsk Regional clinical hospital
Russian Federation
Russian Federation
O. V. Kanya
Irkutsk Regional Pathology Department
Russian Federation
Russian Federation
References
1. Антибиотик-ассоциированнные диареи -тяжелая внутрибольничная патология / С.В. Верещагина [и др.] // Журнал инфекционной патологии. - 2010. - Т. 17, № 4. - С. 35 - 36.
2. Лемешевская М.В. Клинико-эпидемиологические аспекты Clostridium difficile- ассоциированных заболеваний: автореф. дис.. канд. мед. наук. - Иркутск, 2003. - 22 с.
3. Лобзин Ю.В., Захаренко С.М., Иванов Г.А. Современные представления об инфекции Clostridium difficile // Клиническая микробиология и антимикробная химиотерапия. - 2002. - Т. 4, № 3. - С. 200 - 232.
4. Муляр Н.Ф. Комплексное лечение дисбактериоза // Журнал инфекционной патологии. - 2003. - Т. 10, № 4. - С. 76 - 77.
5. Малов В.А., Бондаренко В.М., Пак С.Г. Роль Clostridium difficile в патологии человека // Журнал микробиологии. - 1996. - № 1. - С. 91-96.
6. Муляр Н.Ф. Пробиотики в лечении дисбактериоза // Человек и лекарство: XIV Российский национальный конгресс. - Тез. докл. - М., 2007. - С. 568.
7. Спасов Г.П., Спасов С.Г., Верещагина С.А., Каня О.В. Псевдомембранозный колит - тяжелая нозокомиальная патология // Актуальные вопросы интенсивной терапии. -2009. - № 25. - С. 64 - 65.
8. Bartlett J.G. Antibiotic-associated diarrhea // Clin. Infect. Dis. - 1992. - Vol. 15. - P. 573 - 581.
9. Buchner A.M., Sonnenberg A. Medical diagnoses and procedures associated with Clostridium difficile colitis // Am. J. Gastroenterol. - 2001. -Vol. 96. - P. 766 - 772.
10. Clostridium difficile-associated diarrhea and colitis / D.N. Gerding [et al.] // Infect. Control. Hosp. Epidemiol. - 1995. - Vol. 16. - P. 459 - 477.
11. Decrease in nosocomial Clostridium difficile-associated diarrhea by restricting clindamycin use / S. Pear [et al.] // Ann. Intern. Med. - 1994. -Vol. 120. - P. 272 - 277.
12. McFarland L.V. Epidemiology, risk factors and treatments for antibiotic-associated diarrhea // Diagn. Dis. - 1998. - Vol. 16. - P. 292 - 307.
13. Mylonacis E., Ryan E., Calderwood S. Clostridium difficile-associated diarrhea // Arch. Int. Med. - 2001. - Vol. 161. - P. 525 - 533.
14. Wilkins T., Lyerly D. Clostridium difficile testing: After 20 years, still challenging // J. Clin. microbiol. - 2003. - Vol. 41. - P. 531-534.
Review
For citations:
Mulyar N.F., Vereschagina S.A., Fadeeva T.V., Spasov G.P., Kanya O.V. CLOSTRIDIUM DIFFICILE ASSOCIATED DIARRHEA IN MULTIDISCIPLINARY HOSPITAL. Acta Biomedica Scientifica. 2012;(5(1)):72-75. (In Russ.)
Views:
655
Email this article 
