actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problemsactabiomedica-949Research ArticleЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В БИОЛОГИИ И МЕДИЦИНЕEXPERIMENTAL RESEARCHES IN BIOLOGY AND MEDICINEВЛИЯНИЕ ГИДРОКОРТИЗОНА И БЛОКАДЫ БЕТА-АДРЕНОРЕЦЕПТОРОВ В ЭФФЕКТОРНУЮ ФАЗУ ИММУННОГО ОТВЕТА НА ФАГОЦИТАРНУЮ АКТИВНОСТЬ КЛЕТОК РЕГИОНАРНОГО ЛИМФАТИЧЕСКОГО УЗЛА, МОНОЦИТОВ КРОВИ И ПЕРИТОНЕАЛЬНЫХ МАКРОФАГОВINFLUENCE OF HYDROCORTISONE AND BETA-ADRENERGIC RECEPTOR BLOCKADE IN EFFECTOR PHASE OF THE IMMUNE RESPONSE ON PHAGOCYTIC ACTIVITY OF REGIONAL LYMPH NODE CELLS, BLOOD MONOCYTES AND PERITONEAL MACROPHAGESШиловС. Ю.ShilovS. Ju.stshilov@mail.ruШиловЮ. И.ShilovJu. I.noemail@neicon.ruИнститут экологии и генетики микроорганизмов Уральского отделения РАНInstitute of Ecology and Genetics of Microorganisms UB RASИнститут экологии и генетики микроорганизмов Уральского отделения РАН; Пермская государственная медицинская академия имени академика Е.А. ВагнераInstitute of Ecology and Genetics of Microorganisms UB RAS; Perm State Medical Academy named after acad. E.A. Wagner20122805201203(2)343347Copyright © Шилов С.Ю., Шилов Ю.И., 20122012Шилов С.Ю., Шилов Ю.И.Shilov S.J., Shilov J.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/949

Установлено, что гидрокортизон снижает фагоцитарную активность клеток регионарного лимфатического узла и перитонеальных мононуклеарных фагоцитов, но не влияет на относительные показатели фагоцитарной активности моноцитов периферической крови в эффекторную фазу иммунного ответа у крыс. Эффекты гидрокортизона значительно модифицируются при введении антагониста бета-адренорецепторов пропранолола гидрохлорида.

It was established that hydrocortisone reduces the phagocytic activity of regional lymph node cells and peritoneal mononuclear phagocytes, but does not affect the relative parameters of the phagocytic activity of peripheral blood monocytes in the effector phase of immune response in rats. Effects of hydrocortisone were significantly modified by the administration of beta-adrenoceptor antagonist propranolol hydrochloride.

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The authors declare that there are no conflicts of interest present.