actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problemsactabiomedica-925Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEЧАСТОТА ВСТРЕЧАЕМОСТИ АЛЛЕЛЬНЫХ ВАРИАНТОВ ГЕНОВ TNFRI В ПОЗИЦИЯХ -609 И -1207 И TNFRII ТИПА В ПОЗИЦИЯХ -1709 И -3609 СРЕДИ УСЛОВНО-ЗДОРОВЫХ ДОНОРОВ И У БОЛЬНЫХ РЕВМАТОИДНЫМ АРТРИТОМTHE FREQUENCY OF ALLELIC VARIANTS OF GENES TNFRI AT POSITIONS -609 AND -1207 AND TNFRII AT POSITIONS -1709 AND -3609 IN HEALTHY DONORS AND PATIENTS WITH RHEUMATOID ARTHRITISШкарубаН. С.ShkarubaN. S.noemail@neicon.ruВасильевФ. Ф.VasilievP. P.noemail@neicon.ruСилковА. Н.SilkovA. N.noemail@neicon.ruСенниковаЮ. А.SennikovaJ. A.noemail@neicon.ruЛопатниковаЮ. А.LopatnikovaJ. A.noemail@neicon.ruСизиковА. Э.SizikovA. E.noemail@neicon.ruКалашниковаТ. А.KalashnikovaT. A.noemail@neicon.ruСизякинаЛ. П.SizyakinaL. P.noemail@neicon.ruШульманЮ. Б.ShulmanJ. B.noemail@neicon.ruДолгихС. В.DolgikhS. V.noemail@neicon.ruМазуровВ. И.MazurovV. I.noemail@neicon.ruСенниковС. В.SennikovS. V.noemail@neicon.ruНИИ Клинической иммунологии СО РАМНResearch Institute of Clinical Immunology SB RAMSРостГМУRostov-on-Don State Medical UniversityСПбМАПОMedical Academy of Post-Diploma Education20122805201203(2)237240Copyright © Шкаруба Н.С., Васильев Ф.Ф., Силков А.Н., Сенникова Ю.А., Лопатникова Ю.А., Сизиков А.Э., Калашникова Т.А., Сизякина Л.П., Шульман Ю.Б., Долгих С.В., Мазуров В.И., Сенников С.В., 20122012Шкаруба Н.С., Васильев Ф.Ф., Силков А.Н., Сенникова Ю.А., Лопатникова Ю.А., Сизиков А.Э., Калашникова Т.А., Сизякина Л.П., Шульман Ю.Б., Долгих С.В., Мазуров В.И., Сенников С.В.Shkaruba N.S., Vasiliev P.P., Silkov A.N., Sennikova J.A., Lopatnikova J.A., Sizikov A.E., Kalashnikova T.A., Sizyakina L.P., Shulman J.B., Dolgikh S.V., Mazurov V.I., Sennikov S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/925

В работе была изучена частота встречаемости аллельных вариантов генов TNFRI в позициях -609 и -1207 и TNFRII типа в -1709 и -3609 у больных ревматоидным артритом и в группе популяционного контроля. В группе популяционного контроля полученные частоты аллелей и распределение генотипов промотора гена TNFRI для полиморфных точек -609 и -1207 характерны для азиатских популяций, для полиморфизмов гена TNFRII частоты и распределение отличались от европейских и азиатских популяций. Сравнительный анализ частот аллелей и генотипов промоторных регионов генов TNFRI в позициях -609 и -1207 и TNFRII в позициях -3609 и -1709 у больных ревматоидным артритом и в группе популяционного контроля не выявил статистически значимых различий. Тем не менее, при анализе комбинаций было показано, что в группе больных ревматоидным артритом по сравнению с группой популяционного контроля статистически значимо реже встречается сочетание генотипов TNFRI-609GT + TNFRII-3609CC.

In this paper we studied the frequency of allelic variants of genes TNFRI at positions -609 and -1207 and TNFRII at positions -1709 and -3609 in patients with rheumatoid arthritis and in population control group. It was shown that the resulting frequency distribution of alleles and genotypes of TNFRI gene promoter in a group of population control is characteristic for Asian populations, for TNFRII gene polymorphisms and the frequency distribution differed from the European and Asian populations. Comparative analysis of allele and genotype frequencies of TNFRI gene promoter at positions -609 and -1207 and TNFRII and -3609 and positions -1709 in patients with rheumatoid arthritis and in population control group showed no statistically significant differences. However in the analysis of combinations has been shown that in patients with rheumatoid arthritis compared with the control population was significantly less common combination of genotypes TNFRI-609GT + TNFRII-3609CC.

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The authors declare that there are no conflicts of interest present.