actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problemsactabiomedica-917Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEСОДЕРЖАНИЕ ПОЛИНЕНАСЫЩЕННЫХ ЖИРНЫХ КИСЛОТ (ПНЖК) В МЕМБРАНАХ ЭРИТРОЦИТОВ У ДЕТЕЙ С АТОПИЧЕСКИМ ДЕРМАТИТОМ (АД) РАЗЛИЧНОЙ СТЕПЕНИ ТЯЖЕСТИTHE CONTENT OF POLYUNSATURATED FATTY ACIDS (PUFAS) IN MEMBRANES OF ERYTHROCYTES IN CHILDREN WITH ATOPIC DERMATITIS (AD) OF VARYING SEVERITYТерещенкоС. Ю.TereshchenkoS. Yu.noemail@neicon.ruЛаптеваЛ. В.LaptevaL. V.prale@list.ru;impn@impn.ruНИИ медицинских проблем Севера СО РАМНState Medical Scientific Institute for Northern Problems of Siberian Division of Russian Academy of Medical Sciences20122805201203(2)200203Copyright © Терещенко С.Ю., Лаптева Л.В., 20122012Терещенко С.Ю., Лаптева Л.В.Tereshchenko S.Y., Lapteva L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/917

В настоящее время существует гипотеза о наличии врожденного нарушения обмена полиненасыщенных жирных кислот (ПНЖК), играющего роль в патогенезе атопического дерматита. Постулируется дефицит функции дельта-6-десатуразы, что приводит к недостаточному содержанию в клеточных мембранах производных линолевой кислоты (гамма-линоленовой (ГЛК), дигомолиноленовой и арахидоновой кислот). Кроме того, высказывается мнение о дефиците ω3-ПНЖК при атопических болезнях. Изучен состав жирных кислот, эритроцитов у детей с АД. Получено снижение 14:0, 16:1ω7, 18:1ω9 и 18:3ω6 (ГЛК) кислот в мембранах эритроцитов у детей. Выявлена связь уровня ГЛК с тяжестью АД. Полное отсутствие ГЛК в мембранах выявлено у 83 % детей с тяжелым АД, у 60 % с легким АД и у 41 % здоровых детей, p1-3 = 0,033 Предположено, что снижение ГЛК в клеточных мембранах может быть целью терапевтического вмешательства у детей с АД. В то же время, наше исследование не нашло никаких свидетельств дефицита ω3-ПНЖК у детей с АД.

Currently, there is a hypothesis about the presence of congenital metabolic disorders of polyunsaturated fatty acids (PUFAs), which plays a role in the pathogenesis of atopic dermatitis. It is postulated deficit of deltafunction 6-desaturase, which leads to a lack of content in the cell membranes of derivatives of linoleic acid (gamma-linolenic acid (GLA) and arachidonic acid digomolinolenovoy). In addition, it is suggested a deficit of ω3-PUFA in atopic diseases. The composition of fatty acids of red blood cells in children with AD. Obtained by reduction of 14:0, 16:1 ω7, 18:1ω9 and 18:3ω6 (GLA) acids in erythrocyte membranes in children. The relationship between the level of GLA to the severity of AD. The complete absence of HCA in the membranes was detected in 83 % of children with severe AD, 60 % with mild AD and 41 % of healthy children, p1-3 = 0,033 It is suggested that the decrease in GLA in cell membranes may be the target of therapeutic intervention in children with AD. At the same time, our study found no evidence of ω3-PUFA deficiency in children with AD.

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The authors declare that there are no conflicts of interest present.