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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-903</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>ROC-АНАЛИЗ НЕЙРОИММУНОЛОГИЧЕСКИХ ПОКАЗАТЕЛЕЙ У БОЛЬНЫХ С ХРОНИЧЕСКОЙ ПСИХОГЕННОЙ КРАПИВНИЦЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>ROC-ANALYSIS OF NEUROIMMUNOLOGIC INDICES IN PATIENTS WITH CHRONIC PSYCHOGENIC URTICARIA</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlova</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">lisaorl@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Пензенский институт усовершенствования врачей</institution></aff><aff xml:lang="en"><institution>State Institute of Physicians Training</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>28</day><month>05</month><year>2012</year></pub-date><volume>0</volume><issue>3(2)</issue><fpage>133</fpage><lpage>137</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Орлова Е.А., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Орлова Е.А.</copyright-holder><copyright-holder xml:lang="en">Orlova E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/903">https://www.actabiomedica.ru/jour/article/view/903</self-uri><abstract><p>Психологический стресс связан с повышенным уровнем субстанции Р, посредством которой может осуществляться взаимосвязь психосоматического нейроиммунологического компонентов при хронической крапивнице. В работе применены современные методы статистической обработки полученных результатов. При проведении ROC-анализа определены нейроиммунологические критерии психогенной крапивницы. Показана роль субстанции Р в патогенезе заболевания, подтверждена взаимосвязь уровня субстанции Р и активности ангиотензин-превращающего фермента (АПФ) и проведена оценка степени тревожных расстройств.</p></abstract><trans-abstract xml:lang="en"><p>Psychological stress connects with increased level of substance P, wherewith there may be interconnection between psychosomatic component and neuroimmunologic one in the chronic urticaria. Modern methods of findings statistical manipulation have been used in this work. Neuroimmunologic criteria of psychogenic urticaria were defined by the use of ROC-analysis. Substance P role in the pathogenesis of the disease have been indicated, correlation between substance P level and angiotensin converting enzyme (ACE) activity have been corroborated. Assessment of anxiety disorders level have been carried out.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>крапивница</kwd><kwd>субстанция Р</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ROC-анализ</kwd><kwd>ROC-analysis</kwd><kwd>urticaria</kwd><kwd>substance Р</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гомазков О.А. Физиологически активные пептиды: справ. рук. - М., 1995. - 142 с.</mixed-citation><mixed-citation xml:lang="en">Гомазков О.А. 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