actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problemsactabiomedica-829Research ArticleЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ В БИОЛОГИИ И МЕДИЦИНЕEXPERIMENTAL RESEARCHES IN BIOLOGY AND MEDICINEСИНТЕЗ НОВЫХ НЕНАСЫЩЕННЫХ ТЕЛЛУРОРГАНИЧЕСКИХ СОЕДИНЕНИЙ С ПОТЕНЦИАЛЬНОЙ БИОЛОГИЧЕСКОЙ АКТИВНОСТЬЮSYNTHESIS OF NOVEL UNSATURATED ORGANOTELLURIUM COMPOUNDS WITH POTENTIAL BIOLOGICAL ACTIVITYМусаловаМ. В.MusalovaM. V.maria_musalova@irioch.irk.ruПотаповВ. А.PotapovV. A.v_a_potapov@irioch.irk.ruАмосоваС. В.AmosovaS. V.amosova@irioch.irk.ruИркутский институт химии имени А.Е. Фаворского СО РАНA.E. Favorsky Irkutsk Institute of Chemistry SB RAS, Irkutsk20122804201202(2)117120Copyright © Мусалова М.В., Потапов В.А., Амосова С.В., 20122012Мусалова М.В., Потапов В.А., Амосова С.В.Musalova M.V., Potapov V.A., Amosova S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/829

На основе ацетиленов и тетрагалогенидов теллура разработаны эффективные синтетические подходы, к новым, потенциально биологически активным, теллурорганическим соединениям.

Efficient synthetic approaches to novel organotellurium. compounds with potential biologically activity were elaborated, based, on acetylenes and tellurium, tetrahalid.es.

биологическая активностьтеллурорганические соединениятетрагалогениды теллураацетиленыbiological activityorganotellurium compoundstellurium tetrahalidesacetylenesReferencesПотапов В.А., Мусалова М.В., Амосова С.В. Синтез Е-2-хлорвинилтеллуртрихлорида и Е,Е-бис(2-хлорвинил)дителлурида // Изв. АН. Сер. хим. - 2012. - C. 201 -202.Потапов В.А., Мусалова М.В., Амосова С.В. Синтез Е-2-хлорвинилтеллуртрихлорида и Е,Е-бис(2-хлорвинил)дителлурида // Изв. АН. Сер. хим. - 2012. - C. 201 -202.Реакция тетрахлорида теллура с ацетиленом / В.А. Потапов, М.В. Мусалов, М.В. Мусалова, С.В. Амосова // Изв. АН. Сер. хим. — 2009. — C. 2327-2328.Реакция тетрахлорида теллура с ацетиленом / В.А. Потапов, М.В. Мусалов, М.В. Мусалова, С.В. Амосова // Изв. АН. Сер. хим. — 2009. — C. 2327-2328.A new immunomodulating compound (AS-101) with potential therapeutic application / B. Sredni, R.R. Caspi, A. Klein [et al.] // Nature. - 1987. -Vol. 330. - P. 173-176.A new immunomodulating compound (AS-101) with potential therapeutic application / B. Sredni, R.R. Caspi, A. Klein [et al.] // Nature. - 1987. -Vol. 330. - P. 173-176.A novel organotellurium compound (RT-01) as a new antileishmanial agent / C.B.C. Lima, W.W. Arrais-Silva, R.L.O.R. Cunha, S. Giorgio // Korean J. Parasitol. - 2009. - Vol. 47. - P. 213-218.A novel organotellurium compound (RT-01) as a new antileishmanial agent / C.B.C. Lima, W.W. Arrais-Silva, R.L.O.R. Cunha, S. Giorgio // Korean J. Parasitol. - 2009. - Vol. 47. - P. 213-218.Antioxidative properties of organotellurium compounds in cell systems / E. Wieslander, L. Engman, E. Svensjo [et al.] // Biochem. Pharmacol. - 1998. -Vol. 55. - P. 573-584.Antioxidative properties of organotellurium compounds in cell systems / E. Wieslander, L. Engman, E. Svensjo [et al.] // Biochem. Pharmacol. - 1998. -Vol. 55. - P. 573-584.Bcl-2 expression and apoptosis induction in human HL60 leukaemic cells treated with a novel organotellurium (IV) compound RT-04 / T.S. Abondanza, C.R. Oliveira, C.M. Barbosa [et al.] // Food Chem. Toxicol. - 2008. - Vol. 46. -P. 2540-2545.Bcl-2 expression and apoptosis induction in human HL60 leukaemic cells treated with a novel organotellurium (IV) compound RT-04 / T.S. Abondanza, C.R. Oliveira, C.M. Barbosa [et al.] // Food Chem. Toxicol. - 2008. - Vol. 46. -P. 2540-2545.Binding of tellurium to hepatocellular selenoproteins during incubation with inorganic tellurite: consequences for the activity of selenium-dependent glutathione peroxidase / P. Garberg, L. Engman, V. Tolmachev [et al.] // Int. J. Biochem. Cell. Biol. - 1999. - Vol. 31. - P. 291 -301.Binding of tellurium to hepatocellular selenoproteins during incubation with inorganic tellurite: consequences for the activity of selenium-dependent glutathione peroxidase / P. Garberg, L. Engman, V. Tolmachev [et al.] // Int. J. Biochem. Cell. Biol. - 1999. - Vol. 31. - P. 291 -301.Chasteen T.G., Bentley R. Biomethylation of selenium and tellurium: microorganisms and plants // Chem. Rev. - 2003. - Vol. 103. - P. 1-25.Chasteen T.G., Bentley R. Biomethylation of selenium and tellurium: microorganisms and plants // Chem. Rev. - 2003. - Vol. 103. - P. 1-25.Cytometric determination of novel organotellurium compound toxicity in a promyelocytic (HL-60) cell line / B.L. Sailer, N. Liles, S. Dickerson, T.G. Chasteen // Arch. Toxicol. 2003. - Vol. 77. -P. 30-36.Cytometric determination of novel organotellurium compound toxicity in a promyelocytic (HL-60) cell line / B.L. Sailer, N. Liles, S. Dickerson, T.G. Chasteen // Arch. Toxicol. 2003. - Vol. 77. -P. 30-36.Nogueira C.W., Zeni G., Rocha J.B.T. Organoselenium and organotellurium compounds: toxicology and pharmacology // Chem. Rev. -2004. - Vol. 104. - P. 6255-6285.Nogueira C.W., Zeni G., Rocha J.B.T. Organoselenium and organotellurium compounds: toxicology and pharmacology // Chem. Rev. -2004. - Vol. 104. - P. 6255-6285.Petragnani N., Stefani H.A. Tellurium in Organic Synthesis. - London: Academic Press, 2007. - 372 p.Petragnani N., Stefani H.A. Tellurium in Organic Synthesis. - London: Academic Press, 2007. - 372 p.Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium (IV) compounds as inhibitors of human cathepsin B / R.L. Cunha, M.E. Urano, J.R. Chagas [et al.] // Bioorg. Med. Chem. Lett. - 2005. - Vol. 15. - P. 755-760.Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium (IV) compounds as inhibitors of human cathepsin B / R.L. Cunha, M.E. Urano, J.R. Chagas [et al.] // Bioorg. Med. Chem. Lett. - 2005. - Vol. 15. - P. 755-760.The novel tellurium immunomodulator AS101 inhibits interleukin-10 production and p38 MAPK expression in atopic dermatitis / D. Sredni-Kenigsbuch, M. Shohat, B. Shohat [et al.] // J. Dermatol. Sci. 2008. - Vol. 50. - P. 232-235.The novel tellurium immunomodulator AS101 inhibits interleukin-10 production and p38 MAPK expression in atopic dermatitis / D. Sredni-Kenigsbuch, M. Shohat, B. Shohat [et al.] // J. Dermatol. Sci. 2008. - Vol. 50. - P. 232-235.The protective role of the immunomodulator AS101 against chemotherapy-induced alopecia: studies on human and animal models / B. Sredni, R.H. Xu, M. Albeck [et al.] // Int. J. Cancer. - 1996. -Vol. 65. - P. 97-103.The protective role of the immunomodulator AS101 against chemotherapy-induced alopecia: studies on human and animal models / B. Sredni, R.H. Xu, M. Albeck [et al.] // Int. J. Cancer. - 1996. -Vol. 65. - P. 97-103.Vinylic tellurides: from preparation to their applicability in organic synthesis / G. Zeni, D.S. Ludtke, R.B. Panatieri, A.L. Braga // Chem. Rev. - 2006. - Vol. 106. - P. 1032-1076.Vinylic tellurides: from preparation to their applicability in organic synthesis / G. Zeni, D.S. Ludtke, R.B. Panatieri, A.L. Braga // Chem. Rev. - 2006. - Vol. 106. - P. 1032-1076.

The authors declare that there are no conflicts of interest present.