actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problemsactabiomedica-803Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEWS OF LITERATUREФИЗИОЛОГИЯ ОБМЕНА ХОЛЕСТЕРИНА (ОБЗОР)PHYSIOLOGY OF CHOLESTEROL METABOLISM (THE REVIEW)ТюрюминЯ. Л.TyuryuminYA. L.noemail@neicon.ruШантуровВ. А.ShanturovV. A.noemail@neicon.ruТюрюминаЕ. Э.TyuryuminaE. E.noemail@neicon.ruФГБУ «Научный центр реконструктивной и восстановительной хирургии» СО РАМНScientific Center of Reconstructive and Restorative Surgery SB RAMS, IrkutskГУЗ Иркутская ордена «Знак почёта» областная клиническая больницаIrkutsk Regional Clinical Hospital20122804201202(1)153158Copyright © Тюрюмин Я.Л., Шантуров В.А., Тюрюмина Е.Э., 20122012Тюрюмин Я.Л., Шантуров В.А., Тюрюмина Е.Э.Tyuryumin Y.L., Shanturov V.A., Tyuryumina E.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/803

В организме человека существует два источника холестерина: эндогенный (билиарный) и экзогенный (диетарный). Билиарный холестерин, поступая, с пузырной и. печеночной желчью в тонкую кишку, смешивается, с диетарным. Пул абсорбированного холестерина в подвздошной, кишке содержит. 1/3 диетарного и 2/3 билиарного холестерина. Концентрация холестерина в сыворотке крови зависит, от: 1) всасывания: а) диетарного и билиарного холестерина в подвздошной кишке; б) билиарного холестерина в желчном, пузыре; 2) активности биосинтеза: а) холестерина в печени и. тонкой кишке; б) желчных кислот, в печени; 3) скорости элиминации холестерина из крови, печенью; 4) скорости выведения холестерина с печеночной и пузырной желчью в двенадцатиперстную кишку. Наряду с энтерогепатической циркуляции желчных кислот, в организме человека существует энтерогепатическая циркуляция, билиарного холестерина. Предположено, что регуляция концентрации билиарного холестерина, участвующего в энтерогепатической. циркуляции, может, влиять на уровень холестерина в крови.

There are two sources of cholesterol: endogenous (biliary) and exogenous (dietary) in human organism. Biliary cholesterol arrives with cyctic and. hepatic bile in small intestine and. is mixed, with dietary cholesterol. The pool of absorbed cholesterol in the ileum, contains 1/3 of dietary and. 2/3 of biliary cholesterol. Cholesterol concentration, in blood serum, depends on: 1) absorption, of dietary and. biliary cholesterol in the ileum; 2) absorption, of biliary cholesterol in the gallbladder; 3) activity of biosynthesis of cholesterol in the liver and the small intestine; 4) biosynthesis of bile acids in the liver; 5) speed, of elimination, of cholesterol from blood by liver; 6) rate of excretion of biliary cholesterol with, hepatic and. cystic bile into duodenum. Together with, enterohepatic circulation, of bile acids in human organism, there is enterohepatic circulation, of biliary cholesterol. It was proposed, that regulation, of concentration, of biliary cholesterol that participates in enterohepatic circulation, can influence a level of cholesterol in blood.

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