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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2018-3.5.12</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-711</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПЕДИАТРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PEDIATRICS</subject></subj-group></article-categories><title-group><article-title>ВЛИЯНИЕ ГИПОКСИЧЕСКОГО ПОРАЖЕНИЯ ГОЛОВНОГО МОЗГА НА ВЫЖИВАЕМОСТЬ НЕДОНОШЕННЫХ ДЕТЕЙ</article-title><trans-title-group xml:lang="en"><trans-title>THE EFFECT OF HYPOXIC BRAIN DAMAGE ON THE SURVIVAL OF PREMATURE INFANTS</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6131-8184</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лихолетова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Likholetova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>664049, г. Иркутск, Юбилейный, 100.</p><p>кандидат медицинских наук, ассистент кафедры анестезиологии и реаниматологии.</p></bio><bio xml:lang="en"><p>Yubileyniy 100, Irkutsk 664049.</p><p> Candidate of Medical Sciences, Teaching Assistant at the Department of Anesthesiology and Intensive Care Medicine.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6724-5067</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Анурьев</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Anuryev</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>664049, г. Иркутск, Юбилейный, 100.</p><p>врач-ординатор кафедры анестезиологии и реаниматологии.</p></bio><bio xml:lang="en"><p>Yubileyniy 100, Irkutsk 664049.</p><p> Resident Physician at the Department of Anesthesiology and Intensive Care Medicine.</p></bio><email xlink:type="simple">anurev.lesha@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горбачева</surname><given-names>С. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorbacheva</surname><given-names>S. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>664049, г. Иркутск, Юбилейный, 100.</p><p>доктор медицинских наук, профессор, заведующая кафедрой скорой медицинской помощи и медицины катастроф.</p></bio><bio xml:lang="en"><p>Yubileyniy 100, Irkutsk 664049.</p><p>Doctor of Medical Sciences, Professor, Head of the Department of Emergency Medicine.</p></bio><email xlink:type="simple">gorbachevasm@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлова</surname><given-names>Т. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlova</surname><given-names>T. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>664049, г. Иркутск, Юбилейный, 100.</p><p>кандидат медицинских наук, заведующая лечебно-диагностическим центром для новорожденных и детей раннего возраста.</p></bio><bio xml:lang="en"><p>Yubileyniy 100, Irkutsk 664049.</p><p>Candidate of Medical Sciences, Head of the Treatment and Diagnostic center for Newborns and Infants.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Павлов</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Pavlov</surname><given-names>A. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>664049, г. Иркутск, Юбилейный, 100.</p><p>кандидат медицинских наук, заведующий отделением реанимации для новорожденных.</p></bio><bio xml:lang="en"><p>Yubileyniy 100, Irkutsk 664049.</p><p>Candidate of Medical Sciences, Head of the Neonatal Intensive Care Unit.</p></bio><email xlink:type="simple">alexander.b.pavlov@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Иркутская государственная медицинская академия последипломного образования – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России.</institution></aff><aff xml:lang="en"><institution>Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education.</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Иркутская ордена «Знак почёта» областная клиническая больница».</institution></aff><aff xml:lang="en"><institution>Irkutsk Regional Clinical Hospital.</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>28</day><month>09</month><year>2018</year></pub-date><volume>3</volume><issue>5</issue><fpage>76</fpage><lpage>81</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лихолетова Н.В., Анурьев А.М., Горбачева С.М., Павлова Т.И., Павлов А.Б., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Лихолетова Н.В., Анурьев А.М., Горбачева С.М., Павлова Т.И., Павлов А.Б.</copyright-holder><copyright-holder xml:lang="en">Likholetova N.V., Anuryev A.M., Gorbacheva S.M., Pavlova T.I., Pavlov A.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/711">https://www.actabiomedica.ru/jour/article/view/711</self-uri><abstract><p>Поражения центральной нервной системы являются часто встречающейся патологией неонатального периода, при этом одной из основных причин церебральной дисфункции у новорожденных является гипоксия. Целью данного исследования было изучение частоты церебральных нарушений гипоксического типа у недоношенных новорожденных с экстремально низкой массой тела и очень низкой массой тела при рождении и выявление факторов риска, которые неблагоприятно влияли на исход заболевания. Объектом исследования были недоношенные дети, гестационный возраст которых не превышал 31 недели. Основным критерием включения в исследование послужило наличие у детей повреждения головного мозга гипоксическиишемического и гипоксически-геморрагического характера. С целью выявления перинатальных факторов риска выполнялся сбор данных о соматическом здоровье матерей, особенностях течения беременности и родов. Также проводился анализ структуры детской патологии и методов интенсивной терапии. Из 176 обследованных детей церебральные нарушения были верифицированы у 42 (23,5 %). Внутрижелудочковое кровоизлияние II–III степени диагностировано у 34 (80,9 %) новорожденных, ишемия тяжёлой степени – у 8 (19,1 %). С целью определения структуры исхода заболевания все дети были разделены на умерших и выживших. Летальный исход наблюдался в 14 (33,3 %) случаях. Установлено, что у матерей умерших детей чаще встречалась акушерская и сопутствующая экстрагенитальная патологии. Анализ детской патологии показал, что гемодинамически значимый функционирующий артериальный проток и тяжёлая асфиксия в родах значительно чаще встречались у умерших детей. При проведении респираторной терапии пациентам с летальным исходом требовались более высокие значения процентного содержания кислорода во вдыхаемой смеси и пикового давления. Также отмечено, что этим детям чаще приходилось использовать высокие дозы кардиотонических препаратов. Таким образом, представленные факторы риска можно считать предикторами неблагоприятного исхода у детей с данной патологией.</p></abstract><trans-abstract xml:lang="en"><p>The central nervous system injuries are a common neonatal pathology, hypoxia being one of the main causes of cerebral dysfunction. The purpose of this study was studying the incidence of hypoxic cerebral disorders in premature infants with an extremely low body weight and a very low birth weight and revealing the risk factors that adversely affected the disease outcome. The subject of the study was preterm infants whose gestational age did not exceed 31 weeks. The main criterion for inclusion into the study was the presence of hypoxic-ischemic and hypoxic-hemorrhagic brain damage. To reveal the perinatal risk factors, the somatic health of mothers, and pregnancy and childbirth peculiarities were studied. The structure of children’s pathology and intensive care techniques were analyzed. Cerebral disorders were verified in 42 out of 176 patients (23.5 %). 2–3rd-degree intraventricular hemorrhage was diagnosed in 34 newborns (80.9 %), severe ischemia in 8 children (19.1 %). To determine the structure of the disease outcome, all children were divided into deceased and survivors. A fatal outcome was observed in 14 cases (33.3 %). The mothers of deceased children were more likely to have obstetric and concomitant extragenital pathologies. Analysis of pediatric pathology showed that the hemodynamically significant functioning arterial duct and severe asphyxia in childbirth were much more frequent in deceased children. Intensive therapy of deceased children included «hard» parameters of artificial ventilation and high doses of cardiotonic drugs. Thus the presented risk factors can be considered as predictors of an unfavorable outcome in children with this pathology.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>церебральные нарушения</kwd><kwd>внутрижелудочковые кровоизлияния</kwd><kwd>гипоксия</kwd><kwd>недоношенные новорожденные</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cerebral disorders</kwd><kwd>intraventricular hemorrhage</kwd><kwd>hypoxia</kwd><kwd>preterm infants</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Баранов А.А., Альбицкий В.Ю., Волгина С.Я., Менделевич В.Д. Недоношенные дети в детстве и отрочестве. Медико-психосоциальное исследование к IX съезду педиатров России. – М., 2001. – С. 184.</mixed-citation><mixed-citation xml:lang="en">Baranov AA, Albitskiy VYu, Volgina SYa, Mendelevich VD. (2001). Premature infants in childhood and adolescence. 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