In recent years the main mortality reasons were coronary heart disease, hypertension, cancer, peptic and duodenal ulcers, mental illness. Provoking factor of these diseases is chronic stress. It activates lipid peroxidation, which is one of the damaging factors for the internal organs. In the present study, we investigated the possibility to increase stress resistance and to find pathogenetic grounding of the use of plant adaptogens - astragalus, ginseng, and "Arur Tan N 7" in experimental stress. We have shown that all herbal remedies improve metabolic processes in the tissues of experimental animals and regulate the processes of free radical oxidation. Studies have shown that phyto remedy "Arur-Tan N 7 "shows antiradical activity against NO-binding radicals comparable to that of quercetin, rutin and hydroquinone. On this basis, phyto remedy "Arur-Tan N 7" was more effective in animals in simulation of stress induced by strenuous activity, it restores cells energy potential, normalizes "lipid peroxidation - antioxidant protection" balance and maintains the balance of thiols in animal body. Moreover, all tested herbal remedies at the dosages used are not toxic and therefore can be recommended for further studies.