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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2026-11.3.16</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-6184</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОФИЛАКТИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PREVENTIVE MEDICINE</subject></subj-group></article-categories><title-group><article-title>Содержание лейкоцитов и фагоцитоз у мужчин экстремальных профессий в условиях субарктического региона</article-title><trans-title-group xml:lang="en"><trans-title>Leukocytes and phagocytosis in men of extreme professions in the subarctic region</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0745-3099</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сергеева</surname><given-names>Т. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Sergeeva</surname><given-names>T. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сергеева Татьяна Борисовна – кандидат биологических наук, старший научный сотрудник лаборатории физиологии иммунокомпетентных клеток.</p><p>163020 Архангельск, проспект Никольский, 20</p></bio><bio xml:lang="en"><p>Tatyana B. Sergeeva – Cand. Sc. (Biol.), researcher at the Laboratory of Immunocompetent Cell Physiology.</p><p>Nikolsky Avenue, 20, Arkhangelsk 163020</p></bio><email xlink:type="simple">tanya-86@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1735-6690</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шашкова</surname><given-names>Е. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Shashkova</surname><given-names>E. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шашкова Елизавета Юрьевна – кандидат биологических наук, старший научный сотрудник лаборатории физиологии иммунокомпетентных клеток.</p><p>163020 Архангельск, проспект Никольский, 20</p></bio><bio xml:lang="en"><p>Elizaveta Yu. Shashkova – Cand. Sc. (Biol.), researcher at the Laboratory of Immunocompetent Cell Physiology.</p><p>Nikolsky Avenue, 20, Arkhangelsk 163020</p></bio><email xlink:type="simple">eli1255@ya.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4900-4021</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щёголева</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Shchegoleva</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Щёголева Любовь Станиславовна – доктор биологических наук, профессор, главный научный сотрудник, заведующий лабораторией физиологии иммунокомпетентных клеток.</p><p>163020 Архангельск, проспект Никольский, 20</p></bio><bio xml:lang="en"><p>Liubov S. Shchegoleva – Dr. Sc. (Biol.), professor, chief researcher, head of the laboratory of Physiology of Immunocompetent cells.</p><p>Nikolsky Avenue, 20, Arkhangelsk 163020</p></bio><email xlink:type="simple">shchegoleva60@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУН Федеральный исследовательский центр комплексного изучения Арктики им. акад. Н.П. Лаверова Уральского Отделения РАН</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N. Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2026</year></pub-date><pub-date pub-type="epub"><day>02</day><month>08</month><year>2026</year></pub-date><volume>11</volume><issue>3</issue><fpage>131</fpage><lpage>137</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Сергеева Т.Б., Шашкова Е.Ю., Щёголева Л.С., 2026</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="ru">Сергеева Т.Б., Шашкова Е.Ю., Щёголева Л.С.</copyright-holder><copyright-holder xml:lang="en">Sergeeva T.B., Shashkova E.Y., Shchegoleva L.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/6184">https://www.actabiomedica.ru/jour/article/view/6184</self-uri><abstract><p>Мужчины старше 45 лет являются социально значимой группой, большинство из которых достигло профессиональной зрелости, вносит значительный вклад в экономику страны, своей семьи. В Архангельской области состояние здоровья 40–45-летних мужчин (57 %) характеризуется сердечно-сосудистой патологией, 14,7 % – патологией желудочно-кишечного тракта, 47,4 % – бронхолегочной патологией и 17,0 % – заболеваниями опорно-двигательного аппарата. Специалисты гидрографической службы г. Архангельска мужского пола выполняют плановые и специальные гидрографические работы вахтовым методом в течение навигационного периода, совершая кратковременные частые рейсы длительностью 16 суток в Северных морях.</p><sec><title>Цель исследования</title><p>Цель исследования. Проанализировать особенности содержания лейкоцитов и фагоцитоза у гидрографов Архангельского района гидрографической службы СФРФ с учетом возраста и стажа работы в условиях северных морей.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Обследовано 36 мужчин, работающих в гидрографической службе СФ РФ, короткими вахтами по 16 суток: 15 человек в возрасте 30–40 лет со стажем работы 10 лет и 21 человек в возрасте 50–65 лет со стажем работы 20 лет. Определяли содержание лейкоцитов и фагоцитоз в периферической венозной крови с учетом возраста и стажа работы. Для статистической обработки применен пакет прикладных программ Microsoft Excel 2010 и SPSS 20.0 для Windows.</p></sec><sec><title>Результаты</title><p>Результаты. Установлено, что у гидрографов младшей возрастной группы со стажем работы 10 лет в 1,5–2 раза чаще встречается дефицит лейкоцитов, лимфоцитов и моноцитов, взаимосвязанный с низкой активностью фагоцитоза. У старшей возрастной группы лиц со стажем работы 20 лет лейкоцитоз, лимфоцитоз и моноцитоз регистрируются в 1,5 раза чаще на фоне повышенной активности процессов фагоцитоза.</p></sec><sec><title>Заключение</title><p>Заключение. Фагоцитарная активность нейтрофилов выше у старшей возрастной группы со стажем работы 20 лет в экстремальных условиях.</p></sec></abstract><trans-abstract xml:lang="en"><p>Men over the age of 45 are a socially significant group, most of whom have reached professional maturity and make a significant contribution to the country’s economy and their families. In the Arkhangelsk Region, the health status of 40–45-year-old men (57 %) is characterized by cardiovascular pathology, 14.7 % – by gastrointestinal pathology, 47.4 % – by bronchopulmonary pathology, and 17.0 % – by musculoskeletal disorders. Male specialists from the Hydrographic Service in Arkhangelsk carry out planned and special hydrographic works during the navigation period on a rotational basis, making short-term frequent trips of 16 days in the Northern Seas.</p><sec><title>The aim</title><p>The aim. To analyze the features of leukocyte content and phagocytosis in hydrographers of the Arkhangelsk region of the Hydrographic Service of the Russian Federation, taking into account their age and work experience in the northern seas.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Thirty-six men working in the hydrographic service of the Federation Council of the Russian Federation were examined with short 16-day shifts: 15 men aged 30–40 with 10 years of work experience and 21 men aged 50–65 with 20 years of work experience. The leukocytes count and phagocytosis in peripheral venous blood were determined, taking into account age and work experience. For statistical processing, Microsoft Excel 2010 and SPSS 20.0 for Windows were used as software packages.</p></sec><sec><title>Results</title><p>Results. It has been established that hydrographers of the younger age group with 10 years of work experience have a 1.5–2 times higher incidence of leukocyte, lymphocyte, and monocyte deficiency, which is associated with low phagocytosis activity. In the older age group of individuals with 20 years of work experience, leukocytosis, lymphocytosis, and monocytosis are recorded 1.5 times more frequently against the background of increased phagocytosis activity.</p></sec><sec><title>Conclusion</title><p>Conclusion. The phagocytic activity of neutrophils is higher in the older age group with 20 years of experience in extreme conditions.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>лейкоциты</kwd><kwd>лимфоциты</kwd><kwd>фагоцитоз</kwd><kwd>гидрографическая служба</kwd><kwd>субарктический регион</kwd></kwd-group><kwd-group xml:lang="en"><kwd>leukocytes</kwd><kwd>lymphocytes</kwd><kwd>phagocytosis</kwd><kwd>hydrographic service</kwd><kwd>subarctic region</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено в рамках государственного задания «Физиологическая значимость особенностей адаптивных и врожденных иммунных реакций в формировании резервных возможностей иммунного гомеостаза у жителей Арктического региона в зависимости от возраста, пола и профессионального статуса» № гос. регистрации 125021902582-1</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Добродеева Л.К., Штаборов В.А., Меньшикова Е.А., Добродеев К.Г. 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