actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.12737/article_59a614f9da7517.36264813actabiomedica-616Research ArticleКЛИНИЧЕСКАЯ МЕДИЦИНАCLINICAL MEDICINEФАКТОРЫ РИСКА КОГНИТИВНЫХ НАРУШЕНИЙ ПРИ БОЛЕЗНИ ПАРКИНСОНА И ДИСЦИРКУЛЯТОРНОЙ ЭНЦЕФАЛОПАТИИRISK FACTORS OF COGNITIVE IMPAIRMENT IN PARKINSON’S DISEASE AND DISCIRCULATORY ENCEPHALOPATHYСаютинаС. Б.SayutinaS. B.ain2000@rambler.ruШпрахВ. В.ShprakhV. V.irkmapo@irk.ruРожковаН. Ю.RozhkovaN. Y.kaf_inform@mail.ruИркутская государственная медицинская академия последипломного образования - филиал ФГБОУ «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииIrkutsk State Medical Academy of Postgraduate Education - Branch Campus of the Russian Medical Academy of Continuing Professional Education201728042017224547Copyright © Саютина С.Б., Шпрах В.В., Рожкова Н.Ю., 20172017Саютина С.Б., Шпрах В.В., Рожкова Н.Ю.Sayutina S.B., Shprakh V.V., Rozhkova N.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/616

Изучено состояние когнитивных функций у 100 пациентов с болезнью Паркинсона. При наличии сопутствующей дисциркуляторной энцефалопатии когнитивные нарушения выявлены в 90,3 % случаев, при отсутствии - в 28,6 %. Тяжесть когнитивных нарушений при сочетании болезни Паркинсона и дисциркуляторной энцефалопатии коррелирует с возрастом пациентов, выраженностью двигательных нарушений, длительностью и тяжестью артериальной гипертензии, ишемической болезни сердца, наличием острых сердечно-сосудистых событий в анамнезе.

The aim of the study was to examine the state of cognitive functions in patients with Parkinson's disease combined with the dyscirculatory encephalopathy and identify their risk factors for cognitive impairment. The results of the study showed that the frequency of cognitive impairment in patients with Parkinson's disease combined with the dyscirculatory encephalopathy was 90.3 %, Parkinson's disease without brain vascular disease - 28.6 %. Patients with concomitant cerebrovascular disease had more severe frontal deficit (mean score on the FAB in the main group -14.86 ± 2.18, in the control -16.93 ± 2.21; p < 0.0001), which manifested itself in the form of difficulty when performing tests for dynamic movements, simple and complicated reactions of choice, had the worst performance of speech and general mental activity, attention. In order to assess the relationship of certain clinical, social and biological factors with indicators of cognitive functions we conducted Spearman rank correlation analysis. Risk factors for the development of cognitive impairment of Parkinson's disease combined with vascular encephalopathy were age of patients, severity of motor impairment, duration and severity of hypertension, coronary heart disease, and the presence of acute cardiovascular events in history.

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The authors declare that there are no conflicts of interest present.