actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.29413/ABS.2026-11.2.3actabiomedica-6045Research ArticleАКУШЕРСТВО И ГИНЕКОЛОГИЯOBSTETRICS AND GYNAECOLOGYКоллаген: обзор литературных источников и потенциального применения в гинекологической практикеCollagen: a review of literature and potential applications in gynecological practicehttps://orcid.org/0009-0009-6073-8254ТугариноваН. Н.TugarinovaN. N.

Тугаринова Надежда Николаевна – аспирант.

664003, Иркутск, ул. Тимирязева, 16

Nadezhda N. Tugarinova - postgraduate student at the Scientific Center for Family Health and Human Reproduction Problems.

Timiryazev Str., 16, Irkutsk 664003

Nadezh.turova@yandex.ruhttps://orcid.org/0000-0002-5335-1248ЛещенкоО. Я.LeshchenkoO. Ya.

Лещенко Ольга Ярославна - доктор медицинских наук, главный научный сотрудник.

664003, Иркутск, ул. Тимирязева, 16

Olga Y. Leshchenko - Dr. Sc. (Med.), Chief Researcher at the Scientific Center for Family Health and Human Reproduction Problems.

Timiryazev Str., 16, Irkutsk 664003

loyairk@mail.ruФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»Scientific Centre for Family Health and Human Reproduction Problems2026270520261122434Copyright © Тугаринова Н.Н., Лещенко О.Я., 20262026Тугаринова Н.Н., Лещенко О.Я.Tugarinova N.N., Leshchenko O.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/6045

Коллаген, являясь основным структурным белком организма человека, длительное время рассматривался преимущественно в контексте здоровья кожи, суставов и соединительной ткани. В последние годы наблюдается значительный рост интереса к системным эффектам коллагена, что способствует расширению спектра его потенциального применения, включая гинекологическую практику.

Цель обзора. Всесторонний анализ современных научных данных применения гидролизованного коллагена в медицине с акцентом на обоснование его использования в гинекологической практике.

В обзоре детально рассмотрены фундаментальные аспекты коллагена: биохимия, усвояемость, безопасность, антиоксидантные свойства и роль в стимуляции синтеза внеклеточного матрикса. Проведен комплексный поиск литературы в базах данных PubMed, Scopus, Web of Science, Google Scholar, Medline, eLibrary за период 2000–2024 гг. Критерии включения в обзор: рандомизированные контролируемые исследования, метаанализы, систематические обзоры и релевантные экспериментальные работы на английском и русском языках. На основе систематизации данных научных источников, выделены три ключевых перспективных направления использования коллагена в гинекологической практике: сочетанное применение пероральной добавки гидролизата коллагена с энергетическими методами в терапии генитоуринарного синдрома менопаузы у женщин; коррекция менопаузальных метаболических нарушений, направленная на ключевые звенья патогенеза: ингибирование дипептидилпептидазы-4 для улучшения чувствительности к инсулину, регуляцию липидного обмена в печени и жировой ткани, а также снижение системного воспаления; нутритивная поддержка костного метаболизма у пациенток с постменопаузальным остеопорозом. Гидролизованный коллаген, выходя за рамки нутрикосметики, представляет собой перспективный многоцелевой терапевтический агент для комплексного улучшения качества жизни женщин в пери-и постменопаузе.

Collagen, a major structural protein in the human body, has long been considered primarily in the context of skin, joint, and connective tissue health. Recent years have seen a significant increase in interest in the systemic effects of collagen, expanding the range of its potential applications, including gynecological practice.

The aim. Comprehensively analyze current scientific data on the use of hydrolyzed collagen in medicine, with an emphasis on the rationale for its use in gynecological practice.

This review provides a detailed examination of the fundamental aspects of collagen, including its biochemistry, digestibility, safety, antioxidant properties, and its role in stimulating extracellular matrix synthesis. A comprehensive literature search was conducted in PubMed, Scopus, Web of Science, Google Scholar, Medline, and eLibrary for the period 2000–2024. Inclusion criteria for the review included randomized controlled trials, meta-analyses, systematic reviews, and relevant experimental studies in English and Russian. Based on a systematization of scientific literature, three key promising areas for the use of collagen in gynecological practice have been identified: the combined use of oral collagen hydrolysate supplements with energy-based therapies in the treatment of genitourinary syndrome of menopause in women; the correction of menopausal metabolic disorders, targeting key pathogenesis factors: inhibition of dipeptidyl peptidase-4 to improve insulin sensitivity, regulation of lipid metabolism in the liver and adipose tissue, and reduction of systemic inflammation; and nutritional support of bone metabolism in patients with postmenopausal osteoporosis. Hydrolyzed collagen, going beyond nutricosmetics, represents a promising multi-target therapeutic agent for comprehensively improving the quality of life of peri- and postmenopausal women.

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The authors declare that there are no conflicts of interest present.