actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.29413/ABS.2025-10.6.7actabiomedica-5738Research ArticleИНФЕКЦИОННЫЕ БОЛЕЗНИINFECTIOUS DISEASESБиомаркеры оценки тяжести состояния пациентов с геморрагической лихорадкой с почечным синдромомBiomarkers for assessing the severity of patients with hemorrhagic fever with renal syndromehttps://orcid.org/0000-0003-0857-2604ХасановаА. Н.KhasanovaA. N.

Хасанова Алия Наилевна – врач

450054, г. Уфа, Пр. Октября, д. 67/2

Aliya N. Khasanova – doctor

Oktyabrya Ave., 67/2, Ufa 450054

nail_ufa1964@mail.ruhttps://orcid.org/0000-0001-7255-5302ХасановаГ. М.KhasanovaG. M.

Хасанова Гузэль Миргасимовна – доктор медицинских наук, профессор кафедры инфекционных болезней 

450008, г. Уфа, ул. Ленина, д. 3

Guzel’ M. Khasanova – Dr. Sc. (Med.), Professor of the Department of Infectious Diseases

3 Lenin St., Ufa, 450008

gmhasanova@bashgmu.ruhttps://orcid.org/0000-0003-3285-5559ВоробьевВ. А.VorobyovV. A.

Воробьев Владимир Анатольевич – доктор медицинских наук, профессор кафедры факультетской хирургии и урологии ФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава РФ; доцент кафедры урологии и онкологии ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава РФ

450008, г. Уфа, ул. Ленина, д. 3ж 664003, г. Иркутск, ул. Красного Восстания, 1

Vladimir A. Vorobev – Dr. Sc. (Med.), Professor of the Department of Faculty Surgery and Urology at the Irkutsk State Medical University; Associate Professor of the Department of Urology and Oncology of the Bashkir State Medical University

3 Lenin St., Ufa, 450008; Krasnogo Vosstaniya St., 1, Irkutsk 664003

denecer@yandex.ruhttps://orcid.org/0000-0003-2125-4897ПавловВ. Н.PavlovV. N.

Павлов Валентин Николаевич – доктор медицинских наук; профессор, Академик РАН, заведующий кафедрой урологии; ректор

450008, г. Уфа, ул. Ленина, д. 3

Valentin N. Pavlov – Dr. Sc. (Med.), Professor; member of the Russian Academy of Sciences; Head of the Department of Urology; Rector

3 Lenin St., Ufa, 450008

https://orcid.org/0009-0002-3209-3216ХасановД. Н.KhasanovD. N.

Хасанов Динар Наилевич – врач

450005 г. Уфа, ул. Достоевского, 132

Dinar N. Khasanov – Physician

Dostoevsky St., 132, Ufa 450005

Human-Ecology@yandex.ruhttps://orcid.org/0000-0001-9326-3755ВанГ. Ц.WangG.

Ван Гоцин – доктор медицинских наук, профессор

130012, г. Чанчунь, район Чаоян, ул. Цяньцзинь, 2699, КНР

Wang Guoqing – Dr. Sc. (Med.), Professor, College of Basic Medical Science

2699 Qianjin Road, Chaoyang District, Changchun 130012, China

 

qing@jlu.edu.cnКардио-неврологический центр «Медси-ПроМедицина»Cardio-Neurological Center "MedsiProMeditsina"ФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава РоссииBashkir State Medical University of the Russian Ministry of HealthФГБОУ ВО «Башкирский государственный медицинский университет» Минздрава России; ФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава РоссииBashkir State Medical University of the Russian Ministry of Health; Irkutsk State Medical University of the Russian Ministry of HealthРеспубликанская клиническая больница им. Г.Г. КуватоваRepublican Clinical Hospital named after G.G. KuvatovaЦзилиньский университетJilin University2025140120261065667Copyright © Хасанова А.Н., Хасанова Г.М., Воробьев В.А., Павлов В.Н., Хасанов Д.Н., Ван Г.Ц., 20252025Хасанова А.Н., Хасанова Г.М., Воробьев В.А., Павлов В.Н., Хасанов Д.Н., Ван Г.Ц.Khasanova A.N., Khasanova G.M., Vorobyov V.A., Pavlov V.N., Khasanov D.N., Wang G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/5738

природно-очаговых инфекций в Российской Федерации. На сегодняшний день рутинно при ГЛПС оцениваются обычно общеклинические анализы (кровь с формулой, тромбоциты; моча на протеинурию/гематурию), биохимия (креатинин, мочевина, печеночные ферменты, электролиты, коагулограмма), СРБ. Эти показатели позволяют составить определенную картину тяжести заболевания. Со времени изучения ГЛПС проведено большое количество исследований и выявлены биомаркеры тяжести течения заболевания, которые не используются в практической медицине по разным причинам, одна из которых не достаточная осведомленность врачей о данных биомаркерах.

Цель

Цель. Оценить информативность исследования уровня современных биомаркеров в прогнозировании течения ГЛПС.

Материалы и методы

Материалы и методы. Анализ опубликованных данных (как российских, так и зарубежных, в том числе результаты собственных исследований) о биомаркерах тяжести ГЛПС в поисковых системах PubMed, Scopus, Google Scholar, КиберЛенинка и eLIBRARY за последние 15 лет.

Результаты

Результаты. Рассмотрены биомаркеры, ассоциированные с осложнениями ГЛПС: иммунные и воспалительные показатели, маркеры эндотелиального повреждения, коагуляционные факторы, специфические индикаторы почечного повреждения.

Заключение

Заключение. Цитокины (IL-6, IL-8, IL-10) стабильно ассоциированы с тяжестью ГЛПС. Маркеры воспаления острой фазы (ферритин, прокальцитонин) помогают оценить степень системного воспаления. Показатели эндотелиальной дисфункции (PTX3, галектин-3BP, suPAR, YKL-40, резистин) предсказывают тяжесть гипотензии, отёков и ОПП. Коагулопатические показатели (тромбоциты, D-димер, фибриноген, ПВ/АЧТВ) указывают на риск кровотечений и мультиорганной недостаточности. Специфические почечные маркеры (NGAL, KIM-1, мочевая IL-18) дают возможность прогнозировать тяжесть острого повреждения почек еще до развития необратимой ОПН. Комбинированное применение данных биомаркеров улучшит раннее выявление «угрожаемых» пациентов и, в итоге, повысит эффективность лечения геморрагической лихорадки с почечным синдромом.

Introduction

Introduction. Hemorrhagic fever with renal syndrome (HFRS) holds a leading position among natural focal infections in the Russian Federation. Currently, routine evaluation of HFRS primarily includes general clinical tests (complete blood count with differential, platelet count; urinalysis for proteinuria/hematuria), biochemical parameters (creatinine, urea, liver enzymes, electrolytes, coagulation profile), and C-reactive protein (CRP). These indicators provide a general understanding of disease severity. Since the initial investigations of HFRS, numerous studies have identified biomarkers associated with disease severity, which, however, are not utilized in clinical practice for various reasons

— one of the main ones being insufficient awareness among healthcare providers.

The aim

The aim. To analyze modern laboratory tests that may be employed for predicting severe forms of HFRS.

Materials and methods

Materials and methods. A review of published data (both Russian and international, including the results of our own research) on HFRS severity biomarkers was conducted using PubMed, Google Scholar, and CyberLeninka databases over the past 15 years.

Results

Results. The review included biomarkers associated with HFRS complications: immune and inflammatory markers, indicators of endothelial injury, coagulation factors, and specific markers of renal damage.

Conclusion

Conclusion. Cytokines such as IL-6, IL-8, and IL-10 are consistently associated with HFRS severity. Acute-phase inflammatory markers (ferritin, procalcitonin) aid in assessing the degree of systemic inflammation. Markers of endothelial dysfunction (PTX3, galectin-3BP, suPAR, YKL-40, resistin) help predict the severity of hypotension, edema, and acute kidney injury. Coagulation indicators (platelet count, D-dimer, fibrinogen, PT/aPTT) reflect the risk of bleeding and multiorgan failure. Specific renal biomarkers (NGAL, KIM-1, urinary IL-18) allow for early prediction of acute kidney damage before irreversible renal failure develops. Combined application of these biomarkers can significantly improve early identification of high-risk patients and ultimately enhance the effectiveness of HFRS treatment.

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The authors declare that there are no conflicts of interest present.