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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2025-10.5.22</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-5703</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФАРМАКОЛОГИЯ И ФАРМАЦИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PHARMACOLOGY AND PHARMACEUTICS</subject></subj-group></article-categories><title-group><article-title>Этнофармакологические характеристики Piper betle из  индонезийско-азиатского региона и перспективы его использования в биомедицинских целях</article-title><trans-title-group xml:lang="en"><trans-title>Ethnopharmacological characteristics of Piper betle from Indonesian-Asian region and prospects of its use in  biomedical purposes</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-3444-7351</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Заранайна</surname><given-names>З. Р.-Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Zaranaina</surname><given-names>Z. R.-L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Заранайна Зизиелла Роз-Лис – аспирант кафедры общей фармацевтической и биомедицинской технологии, </p><p>117198, Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Ziziella Rose-Lys Zaranaina – postgraduate student, Department of General Pharmaceutical and Biomedical Technology,</p><p>Miklukho-Maklaya st., 6, Moscow 117198</p></bio><email xlink:type="simple">zaranainaroselys@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7333-2263</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суслина</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Suslina</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Суслина Светлана Николаевна – доктор фармакологических наук, заведующий кафедрой общей фармацевтической и биомедицинской технологии, </p><p>117198, Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Svetlana N. Suslina – Dr. Sc. (Pharm.), Head of the Department of General Pharmaceutical and Biomedical Technology, </p><p>Miklukho-Maklaya st., 6, Moscow 117198</p></bio><email xlink:type="simple">suslina-sn@rudn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-2437-6218</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козлова</surname><given-names>Ю. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozlova</surname><given-names>Y. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Козлова Юлия Константиновна – ассистент кафедры общей фармацевтической и биомедицинской технологии, Медицинский институт, </p><p>117198, Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Yulia K. Kozlova – Assistant, Department of General Pharmaceutical and Biomedical Technology, Medical Institute, </p><p>Miklukho-Maklaya st., 6, Moscow 117198</p></bio><email xlink:type="simple">kozlova-yuk@rudn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8201-4590</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эбзеева</surname><given-names>А. М.-А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ebzeyeva</surname><given-names>A. M.-A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эбзеева Алимат Мусса-Алиевна – кандидат фармакологических наук, старший преподаватель кафедры управления и экономики фармации, Медицинский институт, </p><p>117198, Москва, ул. Миклухо-Маклая, д. 6</p></bio><bio xml:lang="en"><p>Alimat M.-A. Ebzeeva – Cand. Sc. (Pharm.), Senior Lecturer, Department of Pharmacy Management and Economics, Medical Institute, </p><p>Miklukho-Maklaya st., 6, Moscow 117198</p></bio><email xlink:type="simple">ebzeeva-am@rudn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4917-3992</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Паевская</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Paevskaya</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Паевская Ольга Александровна – кандидат медицинских наук, доцент кафедры инфекционных болезней, </p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Olga A. Payevskaya – Cand. Sc. (Med.), Associate Professor, Department of Infectious Diseases, </p><p>Trubetskaya St., 8, b. 2 Moscow 119991</p></bio><email xlink:type="simple">paevskajao@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2009-8354</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лисова</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lisova</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лисова Полина Александровна – ассистент кафедры инфекционных болезней, </p><p>119991, Москва, ул. Трубецкая, д. 8, стр. 2</p></bio><bio xml:lang="en"><p>Polina A. Lisova – Assistant, Department of Infectious Diseases, </p><p>Trubetskaya St., 8, b. 2 Moscow 119991</p></bio><email xlink:type="simple">paolino31@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1943-6245</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марусич</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Marusich</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Марусич Елена Ивановна – кандидат биологических наук, заместитель заведующего лабораторией, </p><p>141700, Долгопрудный, Институтский пер., д. 9/3</p></bio><bio xml:lang="en"><p>Elena I. Marusich – Cand. Sc. (Biol.), Deputy Head of Laboratory, </p><p>Institutskiy per., 9/3, Dolgoprudny 141700</p></bio><email xlink:type="simple">marusich.ei@mipt.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет дружбы народов имени Патриса Лумумбы</institution></aff><aff xml:lang="en"><institution>Peoples’ Friendship University of Russia named after Patrice Lumumba</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый МГМУ имени И.М. Сеченова Минздрава России (Сеченовский Университет)</institution></aff><aff xml:lang="en"><institution>First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of the Russian Federation (Sechenov University)</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Институт Биофизики Будущего, Московский физико-технический институт (Национальный&#13;
Исследовательский Университет)</institution></aff><aff xml:lang="en"><institution>Institute of Biophysics of the Future Moscow Institute of Physics and Technology (National Research University)</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>17</day><month>12</month><year>2025</year></pub-date><volume>10</volume><issue>5</issue><fpage>205</fpage><lpage>214</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Заранайна З.Р., Суслина С.Н., Козлова Ю.К., Эбзеева А.М., Паевская О.А., Лисова П.А., Марусич Е.И., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Заранайна З.Р., Суслина С.Н., Козлова Ю.К., Эбзеева А.М., Паевская О.А., Лисова П.А., Марусич Е.И.</copyright-holder><copyright-holder xml:lang="en">Zaranaina Z.R., Suslina S.N., Kozlova Y.K., Ebzeyeva A.M., Paevskaya O.A., Lisova P.A., Marusich E.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/5703">https://www.actabiomedica.ru/jour/article/view/5703</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Piper betle семейства перечных Piperaceae, (P. betle) — лиана, произрастающая в тропиках Индонезийско-Азиатского региона, издавна активно используется в народной медицине в качестве источника средств для решения самых различных проблем со здоровьем. Вместе с тем, способы и цели использования P. betle в народной медицине различаются от региона к региону, а эффективность его воздействия на человека остается недооцененной в полной мере.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Систематизировать и проанализировать современные литературные данные о фармакологическом потенциале лекарственного растения Piper betle, произрастающего в странах Индонезийско-Азиатского региона: Мадагаскар, Индия, Бали и Китай.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Поиск и анализ данных проводился в международных и региональных базах данных (PubMed, Scopus, Web of Science, ScienceDirect, Google Scholar) за период с 1996 по 2025 гг.</p></sec><sec><title>Результаты</title><p>Результаты. В ходе анализа научных литературных данных было показано, что целевой фрагмент метаболома (ЦМФ) Peper betle характеризуется сложным составом биологически активных веществ (БАВ), который существенно варьирует от региона к региону. БАВ ЦФМ этого растения отвечают за различные виды фармакологической активности, что оправдывает его применение в традиционной медицине и вызывает растущий интерес со стороны медицинского научного сообщества. Установлено, что в пределах ареала произрастания P. betle отличается вариабельностью химического состава ЦФМ по содержанию алкалоидов, терпенов, фенольных соединений, в том числе флавоноидов и летучих компонентов.</p></sec><sec><title>Заключение</title><p>Заключение. P. betle представляет собой перспективный объект для дальнейших исследований в области фитофармакологии и репродуктивной медицины. Очевидно, для подтверждения выявленных эффектов на основе литературных источников необходимы углубленные доклинические и клинические исследования. Вместе с тем, собранные литературные данные могут способствовать проведению будущих исследований в области фармакологии с целью создания новых перспективных лекарственных средств.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Rationale</title><p>Rationale. Piper betle of the family of Piperaceae, (P. betle) is a liana growing in the tropics of the Indonesian-Asian region, has long been actively used in folk medicine as a source of remedies for a variety of health problems. At the same time, the methods and purposes of using P. betle in folk medicine vary from region to region, and the effectiveness of its impact on human remains fully underestimated.</p></sec><sec><title>The aim of the study</title><p>The aim of the study. To systematize and analyze modern literature data on the pharmacological potential of the medicinal plant Piper betle, growing in the countries of Madagascar, India, Bali and China of the Indonesian-Asian region.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The search and analysis of data were carried out in international and regional databases (PubMed, Scopus, Web of Science, Science Direct, and Google Scholar) for the period from 1996 to 2025.</p></sec><sec><title>Results</title><p>Results. The analysis of scientific literature data showed that the target fragment of metabolome (TFM) of Peper betle is characterized by a complex composition of biologically active compounds (BAS), which varies significantly from region to region. BAS of the TFM of this plant are responsible for various types of pharmacological activity, which justifies its use in traditional medicine and growing interest to the medical scientific community. It was found that within the range of P. betle growth, the chemical composition of TFM varies in terms of the content of alkaloids, terpenes, phenolic compounds, including flavonoids and volatile components.</p></sec><sec><title>Conclusion</title><p>Conclusion. P. betle is a promising object for further research in the field of phytopharmacology and reproductive medicine. Obviously, in-depth preclinical and clinical studies are needed to confirm the identified effects based on literature sources. At the same time, the collected literature data can contribute to future research in the field of pharmacology in order to create new promising drugs.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>Piper betle</kwd><kwd>этноботаника</kwd><kwd>фитохимия</kwd><kwd>химический состав</kwd><kwd>биологическая активность</kwd><kwd>традиционная медицина</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Piper betle</kwd><kwd>ethnobotany</kwd><kwd>phytochemistry</kwd><kwd>chemical composition</kwd><kwd>biological activity</kwd><kwd>traditional medicine</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sagar WH, Amol MA, Bhaurao K, Head K. Piper betle a herbal plant: A review. Int J Food Sci and Nutr. 2025; 10(1):27–35. URL: https://www.foodsciencejournal.com/assets/archives/2025/vol10issue1/10006.pdf. 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