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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2025-10.5.15</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-5680</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОФТАЛЬМОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPHTHALMOLOGY</subject></subj-group></article-categories><title-group><article-title>Оценка эффективности комбинированного лечения ретинита Коатса</article-title><trans-title-group xml:lang="en"><trans-title>Evaluation of the effectiveness of combination treatment for Coats’ retinitis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5343-0691</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Букина</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bukina</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Букина Вера Васильевна – кандидат медицинских наук, врач-офтальмолог, заведующая 3-м офтальмологическим отделением </p><p>664017, г. Иркутск, ул. Лермонтова, д. 337, Россия </p></bio><bio xml:lang="en"><p>Vera V. Bukina – Cand. Sc. (Med.), Ophthalmologist, Head of the 3rd ophthalmology department </p><p>Lermontov str., 337, Irkutsk 664033, Russian Federation </p></bio><email xlink:type="simple">bukina.viera@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4264-4408</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щуко</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Shchuko</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Щуко Андрей Геннадьевич – доктор медицинских наук, профессор, директор; заведующий кафедрой офтальмологии; заведующий кафедрой глазных болезней</p><p>664017, г. Иркутск, ул. Лермонтова, д. 337, Россия </p><p>664003, г. Иркутск, ул. Красного Восстания, д. 1, Россия</p><p>664049, г. Иркутск, м-н Юбилейный, д. 100, Россия </p></bio><bio xml:lang="en"><p>Andrey G. Shchuko – Dr. Sc. (Med.), Professor, Director; Head of the Department of Ophthalmology; Head of the Department of Eye Diseases</p><p>Lermontov str., 337, Irkutsk 664033, Russian Federation</p><p>Krasnogo vosstaniya str., 1, Irkutsk 664003, Russian Federation</p><p>Yubileyny Microdistrict, 100, Irkutsk, 664049, Russian Federation </p></bio><email xlink:type="simple">if@mntk.irkutsk.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0227-7682</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жукова</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhukova</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жукова Светлана Ивановна – кандидат медицинских наук, заведующая диагностическим отделением, врач-офтальмолог высшей категории </p><p>664017, г. Иркутск, ул. Лермонтова, д. 337, Россия </p></bio><bio xml:lang="en"><p>Svetlana I. Zhukova – Cand. Sc. (Med.), Head of the Diagnostic Department, ophthalmologist </p><p>Lermontov str., 337, Irkutsk 664033, Russian Federation</p></bio><email xlink:type="simple">zhukswetlana@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0547-7521</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юрьева</surname><given-names>Т. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Iureva</surname><given-names>T. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юрьева Татьяна Николаевна – доктор медицинских наук, профессор, заместитель директора по научной работе; профессор кафедры офтальмологии; профессор кафедры глазных болезней</p><p>664017, г. Иркутск, ул. Лермонтова, д. 337, Россия </p><p>664003, г. Иркутск, ул. Красного Восстания, д. 1, Россия</p><p>664049, г. Иркутск, м-н Юбилейный, д. 100, Россия </p></bio><bio xml:lang="en"><p>Tatiana N. Iureva – Dr. Sc. (Med.), Professor, Deputy Director for Science;  Professor at the Department of Ophthalmology; Professor at the Department of Eye Diseases</p><p>Lermontov str., 337, Irkutsk 664033, Russian Federation</p><p>Krasnogo vosstaniya str., 1, Irkutsk 664003, Russian Federation</p><p>Yubileyny Microdistrict, 100, Irkutsk, 664049, Russian Federation </p></bio><email xlink:type="simple">tnyurieva@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0851-819X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Борисова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Borisova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Борисова Анна Валентиновна – врач-офтальмолог 3-го офтальмологического отделения  </p><p>664017, г. Иркутск, ул. Лермонтова, д. 337, Россия </p></bio><bio xml:lang="en"><p>Anna V. Borisova – Ophthalmologist of the 3rd ophthalmology department</p><p>Lermontov str., 337, Irkutsk 664033, Russian Federation</p></bio><email xlink:type="simple">anyborisbb@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Иркутский филиал ФГАУ «НМИЦ «МНТК «Микрохирургия  глаза» им. акад. С.Н. Федорова» Министерства здравоохранения Российской Федерации</institution></aff><aff xml:lang="en"><institution>Irkutsk Branch of S.N. Fyodorov Eye Microsurgery Federal State Institution, Ministry of health of the Russian Federation</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Иркутский филиал ФГАУ «НМИЦ «МНТК «Микрохирургия  глаза» им. акад. С.Н. Федорова» Министерства здравоохранения Российской Федерации;&#13;
ФГБОУ ВО «Иркутский государственный медицинский университет» Министерства здравоохранения Российской Федерации;&#13;
ИГМАПО – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Министерства здравоохранения Российской Федерации</institution></aff><aff xml:lang="en"><institution>Irkutsk Branch of S.N. Fyodorov Eye Microsurgery Federal State Institution, Ministry of health of the Russian Federation;&#13;
Irkutsk State Medical University of the Ministry of Health of the Russian Federation;&#13;
Irkutsk State Medical Academy of Postgraduate Education – branch of the Russian Medical Academy of Postgraduate Education of the Ministry of Health of the Russian Federation</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>17</day><month>12</month><year>2025</year></pub-date><volume>10</volume><issue>5</issue><fpage>132</fpage><lpage>142</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Букина В.В., Щуко А.Г., Жукова С.И., Юрьева Т.Н., Борисова А.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Букина В.В., Щуко А.Г., Жукова С.И., Юрьева Т.Н., Борисова А.В.</copyright-holder><copyright-holder xml:lang="en">Bukina V.V., Shchuko A.G., Zhukova S.I., Iureva T.N., Borisova A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/5680">https://www.actabiomedica.ru/jour/article/view/5680</self-uri><abstract><p>Целью данной работы является оценка эффективности комбинированного лечения ретинита Коатса с применением антиангиогенной терапии и лазеркоагуляции сетчатки.На примере клинического случая показаны преимущества комбинированного поэтапного лечения ретинита Коатса. Выраженное усиление экссудативных проявлений в макулярной области и по ходу нижне-височной сосудистой аркады после лазеркоагуляции сетчатки (отграничительная, барраж макулы) не позволило бы провести следующий этап лазерного лечения без серьёзных осложнений. Поэтому применение анти-VEGF препаратов в качестве адъювантной терапии оптимально для создания благоприятных условий для следующего этапа лазеркоагуляции. Учитывая, что течение ретинита Коатса у взрослых пациентов часто ассоциировано с гиперхолестеринемией, необходимо проведение липидограммы и назначение адекватной коррекции выявленных нарушений, что также способствует снижению экссудации холестерина. Таким образом, комбинированное поэтапное лечение ретинита Коатса у данной пациентки позволило стабилизировать патологический процесс и сохранить высокую остроту зрения.Заключение. Основным методом лечения ретинита Коатса остаётся лазеркоагуляция. Однако применение анти-VEGF препаратов в качестве неоадъювантной либо адъювантной терапии способствует стабилизации патологического процесса и сохранению максимально возможного зрения у пациента.</p></abstract><trans-abstract xml:lang="en"><p>The aim of this study is to evaluate the efficacy of a combined treatment modality for Coats’ disease, integrating anti-angiogenic therapy with retinal laser photocoagulation.The presented clinical case illustrates the advantages of a combined, staged treatment approach for Coats’ disease. A marked increase in exudative manifestations within the macular region and along the inferior-temporal vascular arcade, observed following the initial session of retinal laser photocoagulation (which included barrier and delimiting applications to the macula), would have precluded subsequent laser intervention without a significant risk of complications. Consequently, the administration of anti-VEGF agents as adjuvant therapy proved optimal for establishing favorable conditions for the next stage of laser photocoagulation. Given that the clinical course of Coats’ disease in adult patients is frequently associated with hypercholesterolemia, performing a lipid profile and initiating appropriate corrective measures for any identified dyslipidemia is essential. This management also contributes to the reduction of cholesterol exudation. Thus, the implemented combined, staged treatment regimen in this patient resulted in the stabilization of the pathological process and the preservation of high visual acuity.Conclusion. Laser photocoagulation remains the primary treatment for Coats’ disease. However, the use of anti-VEGF agents, either as neoadjuvant or adjuvant therapy, facilitates the stabilization of the pathological process and aids in the preservation of the patient’s maximum potential visual function.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ретинит Коатса</kwd><kwd>ретинальная артериальная макроаневризма</kwd><kwd>отёк сетчатки</kwd><kwd>лазеркоагуляция сетчатки</kwd><kwd>ингибиторы ангиогенеза</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Coats’ disease</kwd><kwd>retinal arterial macroaneurysm</kwd><kwd>retinal edema</kwd><kwd>retinal laser coagulation</kwd><kwd>angiogenesis inhibitors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ucgul AY, Özdek Ş. Coats› Disease: A Comprehensive Review of Its Pathophysiology, Diagnosis, and Advances in Treatment. 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