actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.29413/ABS.2025-10.5.6actabiomedica-5661Research ArticleВНУТРЕННИЕ БОЛЕЗНИINTERNAL DISEASESВлияние групп крови на предрасположенность к некоторым заболеваниям: молекулярные механизмы и клинические импликации (краткий обзор)The influence of blood groups on predisposition to certain diseases: molecular mechanisms and clinical implications (Brief-Review)https://orcid.org/0000-0002-4093-2502МакароваО. А.MakarovaO. A.

664003, Иркутск, ул. Красного Восстания, 1, Россия 

Olga A. Makarova – Cand. Sc. (Biol), associate professor, head of histology, embryology, cytology department

Krasny Vosstaniya str., 1, Irkutsk 664003, Russian Federation

lga2011@yandex.ruhttps://orcid.org/0009-0003-9898-852XФилипцеваЕ. Е.FiliptsevaE. E.

664003, Иркутск, ул. Красного Восстания, 1, Россия 

Elizaveta E. Filiptseva – student

Krasny Vosstaniya str., 1, Irkutsk 664003, Russian Federation

elizavetafiliptseva@gmail.comhttps://orcid.org/0009-0003-9278-0015СусликоваМ. И.SuslikovaM. I.

664003, Иркутск, ул. Красного Восстания, 1, Россия 

Maria I. Suslikova – Cand. Sc. (Med), associate professor, head of normal physiology department

Krasny Vosstaniya str., 1, Irkutsk 664003, Russian Federation

smibalis2@rambler.ruhttps://orcid.org/0000-0003-3255-2013ДаренскаяМ. А.DarenskayaM. A.

664003, Иркутск, ул. Красного Восстания, 1, Россия 

664003, Иркутск, ул. Тимирязева, 16, Россия

Marina A. Darenskaya – Dr. Sc. (Biol.), professor of the Russian Academy of Sciences, chief researcher, head of the laboratory of pathophysiology; senior lecturer of normal physiology department

Krasny Vosstaniya str., 1, Irkutsk 664003, Russian Federation

Timiryazev str., 16, Irkutsk 664003, Russian Federation

marina_darenskaya@inbox.ruhttps://orcid.org/0000-0002-4152-3620ТирскаяО. И.TirskayaO. I.

664003, Иркутск, ул. Красного Восстания, 1, Россия 

Oksana I. Tirskaya – Cand. Sc. (Med), associate professor, head of therapeutic dentistry department

Krasny Vosstaniya str., 1, Irkutsk 664003, Russian Federation

tiroks@list.ruhttps://orcid.org/0000-0001-9103-6153КазанковаЕ. М.KazankovaE. M.

664003, Иркутск, ул. Красного Восстания, 1, Россия 

Elena M. Kazankova – Cand. Sc. (Med), associate professor of therapeutic dentistry department

Krasny Vosstaniya str., 1, Irkutsk 664003, Russian Federation

iemk@mail.ruhttps://orcid.org/0009-0004-4938-8904МакароваП. Е.MakarovaP. E.

199034, Санкт-Петербург, Университетская наб., 7/9, Россия 

Polina E. Makarova – student 

Universitetskaya Emb., 7/9, Saint Petersburg 199034, Russian Federation 

apolinaria.makarova.03@mail.ruhttps://orcid.org/0009-0004-6944-3915СусликоваТ. А.SuslikovaT. A.

664003, Иркутск, ул. Красного Восстания, 1, Россия 

Taisiya A. Suslikova – student

Krasny Vosstaniya str., 1, Irkutsk 664003, Russian Federation

suslikova.taisya@yandex.ruФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава РоссииIrkutsk State Medical UniversityФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава России; ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»Irkutsk State Medical University; Scientific Centre for Family Health and Human Reproduction ProblemsСанкт-Петербургский государственный университетSaint Petersburg State University2025171220251056068Copyright © Макарова О.А., Филипцева Е.Е., Сусликова М.И., Даренская М.А., Тирская О.И., Казанкова Е.М., Макарова П.Е., Сусликова Т.А., 20252025Макарова О.А., Филипцева Е.Е., Сусликова М.И., Даренская М.А., Тирская О.И., Казанкова Е.М., Макарова П.Е., Сусликова Т.А.Makarova O.A., Filiptseva E.E., Suslikova M.I., Darenskaya M.A., Tirskaya O.I., Kazankova E.M., Makarova P.E., Suslikova T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/5661

Проблема ранней диагностики и выявления предикторов заболеваний различной этиологии является актуальной. Группа крови может выступать в качестве такого предиктора. Поиск взаимосвязи между группой крови и предрасположенностью к определённым заболеваниям позволит выявлять группы риска по конкретному заболеванию и разрабатывать профилактические меры. Обсуждается взаимосвязь между инфекционными и неинфекционными заболеваниями и группой крови AB0 и другими системами, такими как резус-фактор, система Льюиса. Несмотря на значительный прогресс в изучении механизмов реализации этой взаимосвязи, вопрос остаётся открытым. В обзоре рассматривается современное состояние проблемы и предполагаемые механизмы связи различных групп крови с предрасположенностью к определённым заболеваниям. Наиболее изучена связь между группой крови и онкологическими заболеваниями. Обсуждается связь группы крови не только с определёнными заболеваниями, но и с типологическими чертами личности, темпераментом и реакцией на стрессовые факторы, которые могут предрасполагать к развитию соматических и психических заболеваний. Исследование влияния групп крови на предрасположенность к развитию стоматологических заболеваний посвящены, в основном, связи группы крови AB0 со здоровьем пародонта. Существуют исследования, изучающие распространённость кариеса у людей с разными группами крови. Мы проанализировали более 100 статей, индексированных в RSCI, PubMed и Scopus, в основном за последние 10 лет. Для статьи было использовано 48 источников, из которых 16 опубликованы за последние 5 лет. Работы, опубликованные ранее 2005 года, из анализа исключались.

The problem of early diagnosis and detection of diseases predictors of various etiologies is relevant. Blood type can act as such a predictor. The research for the relationship between blood type and predisposition to certain diseases will make it possible to identify risk groups for a particular disease and develop preventive measures. One such predictor could become blood type. The relationship between infectious (Cholera, the plague, tuberculosis, smallpox etc.) and non-communicable (oncological, neurodegenerative, cardiovascular, dental diseases etc.) AB0 blood type and other systems such as Rhesus, Lewis is being discussed. Although considerable advancements have been achieved in investigating the mechanisms that facilitate this connection, the inquiry remains unresolved. This review examines the current state of the problem and the alleged mechanisms of the association of various blood groups with a predisposition to certain diseases. The relationship between blood type and oncological diseases has been most studied. The relationship of blood type is discussed not only with certain diseases, but also with typological personality traits, temperament, and response to stressful factors that can predispose to the development of somatic and mental illnesses. Studying the influence of blood groups on predisposition to the development of dental diseases is largely devoted to the relationship of blood type AB0 with periodontal health. There are studies examining the prevalence of caries in people with different blood types. We analyzed more than 100 articles indexed in RSCI, PubMed, and Scopus, mainly over the past 10 years. Forty eight sources were used for the article, of which 16 were published in the last 5 years. Works published earlier than 2005 were excluded from the analysis.

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The authors declare that there are no conflicts of interest present.