actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.29413/ABS.2025-10.5.4actabiomedica-5659Research ArticleАКУШЕРСТВО И ГИНЕКОЛОГИЯOBSTETRICS AND GYNAECOLOGYПосттрансляционные модификации белков и их роль в привычном невынашивании беременности: прогнозы и диагностикаPosttranslational modifications and its role in habitual miscarriage: prognosis, diagnosis and new approaches to therapyhttps://orcid.org/0000-0001-5474-1080ЗиганшинА. М.ZiganshinA. M.

Зиганшин Айдар Миндиярович – доктор медицинских наук, профессор кафедры акушерства и гинекологии № 2 

450008, г. Уфа, ул. Ленина, д. 3, Россия

Aydar M. Ziganshin – Dr. Sc. (Med.), Professor of the Department of Obstetrics and Gynecology with a course at the Institute of Additional Professional Education

3 Lenin St., 450008 Ufa, Russian Federation 

zigaidar@yandex.ruhttps://orcid.org/0000-0001-9524-8962ДиккеГ. Б.DikkeG. B.

Дикке Галина Борисовна – доктор медицинских наук, профессор кафедры акушерства и гинекологии с курсом репродуктивной медицины 

190013, г. Санкт-Петербург, ул. Московский пр-кт, д. 22 литер М, Россия

Galina B. Dikke –Dr. Sc. (Med.), Professor, Department of Obstetrics and Gynecology with a Course of Reproductive Medicine

22 Moskovsky Ave., St. Petersburg 190013, Russian Federation 

galadikke@yandex.ruhttps://orcid.org/0009-0008-6183-9930МусинаА. М.MusinaA. M.

Мусина Алия Маратовна – студентка 5 курса лечебного факультета 

450008, г. Уфа, ул. Ленина, д. 3, Россия

Aliya M. Musina – 5th year student of the Faculty of Medicine

3 Lenin St., 450008 Ufa, Russian Federation 

aliya_musina_2020@mail.ruhttps://orcid.org/0009-0002-2348-3474БаяноваР. Р.BayanovaR. R.

Баянова Регина Радиковна – студентка 5 курса лечебного факультета 

450008, г. Уфа, ул. Ленина, д. 3, Россия

Regina R. Bayanova – 5th year student of the Faculty of Medicine

3 Lenin St., 450008 Ufa, Russian Federation 

Reginaradik44@mail.ruhttps://orcid.org/0009-0004-0678-1503ФроловА. Л.FrolovA. L.

Фролов Алексей Леонидович – кандидат медицинских наук, заслуженный врач Российской Федерации, заведующий операционным блоком № 2 

450106, г. Уфа, ул. Батырская, д. 31, Россия 

Alexey L. Frolov – Cand. Sc. (Med.), Honored Doctor of the Republic of Bashkortostan, distinguished physician of the Russian Federation and the Republic of Bashkortostan, Head of the Operating Unit. No. 2 

Batyrskaya str., 31, Ufa 450106, Russian Federation

frolrpc@yandex.ruФГБОУ ВО «Башкирский государственный медицинский университет»Bashkir State Medical UniversityЧОУ ДПО «Академия медицинского образования имени Ф.И. Иноземцева»F.I. Inozemtsev Academy of Medical EducationГБУЗ МЗ РБ «Республиканский клинический перинатальный центр»Republican Clinical University of the Ministry of Health of the Republic of Belarus, Perinatal Center2025171220251053851Copyright © Зиганшин А.М., Дикке Г.Б., Мусина А.М., Баянова Р.Р., Фролов А.Л., 20252025Зиганшин А.М., Дикке Г.Б., Мусина А.М., Баянова Р.Р., Фролов А.Л.Ziganshin A.M., Dikke G.B., Musina A.M., Bayanova R.R., Frolov A.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/5659

Распространенность привычного невынашивания беременности (ПНБ) у женщин по всему миру составляет от 1 до 5 %. Среди известных причин ПНБ в последние годы изучается роль посттрансляционных модификаций белков (ПТМБ) – превращения структуры белков, завершающие формирование их молекулы или участвующие в регуляции функций этой молекулы, и катализируемые специфическими ферментами.Цель. Оценить роль ПТМБ в патогенезе ПНБ, а также определить потенциальные биомаркеры и терапевтические мишени ПНБ.Материал. Проведен поиск публикаций по ключевым словам в электронных базах данных PubMed/MEDLINE и Google Scholar, опубликованных до декабря 2024 г.Результаты. ПТМБ играют важную роль в процессах инвазии трофобласта, децидуализации эндометрия и имплантации эмбриона, что делает их значимыми для понимания нарушений репродуктивной функции. Использование масс-спектрометрии для исследования ПТМБ открывает новые возможности для диагностики и прогноза ПНБ. Эпигенетическая терапия ПНБ демонстрирует эффективность и меньшую вероятность побочных эффектов по сравнению с традиционными методами. Несмотря на значимые перспективы, исследования в этой области сопровождаются трудностями, связанными с неоднородностью терминологии и этическими вопросами.Заключение. ПТМБ в контексте ПНБ может способствовать улучшению диагностических и терапевтических стратегий в репродуктивной медицине. Необходимы дальнейшие разработки методологий для изучения ПТМБ.

The prevalence of recurrent pregnancy loss (RPL) in women ranges from 1 to 5 %. Among the known causes of RPL, the role of post-translational protein modifications (PTMP) has been studied in recent years. These are protein structure transformations that complete the formation of their molecule or participate in the regulation of the functions of this molecule, catalyzed by specific enzymes.The aim. To assess the role of PTMP in the pathogenesis of RPL, as well as to determine potential biomarkers and therapeutic targets of RPL.Material. A search of publications by keywords was conducted in the electronic databases PubMed/MEDLINE and Google Scholar, published before December 2024.Results. PTMB plays an important role in the processes of trophoblast invasion, endometrial decidualization and embryo implantation, which makes them significant for understanding reproductive dysfunction. The use of mass spectrometry to study PTMB opens up new possibilities for the diagnosis and prognosis of RPL. Epigenetic therapy of RPL demonstrates efficacy and a lower probability of side effects compared to traditional methods. Despite significant prospects, research in this area is accompanied by difficulties associated with heterogeneity of terminology and ethical issues.Conclusion. PTMB in the context of RPL can contribute to the improvement of diagnostic and therapeutic strategies in reproductive medicine. Further development of methodologies for studying PTMB is needed.

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The authors declare that there are no conflicts of interest present.