actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.29413/ABS.2025-10.4.13actabiomedica-5560Research ArticleМОРФОЛОГИЯ, ФИЗИОЛОГИЯ И ПАТОФИЗИОЛОГИЯMORPHOLOGY, PHYSIOLOGY AND PATHOPHYSIOLOGYСиндром «спортивного сердца» у молодых спортсменов и изолированная систолическая гипертензия: могут ли «спортивные гены» лежать в основе их взаимосвязи? Результаты пилотного исследованияYoung “athlete’s hearts” and isolated systolic hypertension: can “athlete’s genes” underlie their relationship? Results from the pilot studyhttps://orcid.org/0000-0003-3104-3639КоломейчукС. Н.KolomeichukS. N.

625023; г. Тюмень; ул. Одесская; 54,

185910; г. Петрозаводск; ул.; Пушкинская 11

Sergey N. Kolomeichuk – Cand. Sc. (Biol.); Head of the Laboratory for Genomics; Proteomics; and Metabolomics; Research Institute of Biomedicine and Biomedical Technologies; Tyumen State Medical University; senior research officer at the Laboratory of Genetics; Institute of Biology; Karelian Research Centre; Russian Academy of Sciences

Odesskaya; 54; Tyumen 625023,

Pushkinskaya str.; 11; Petrozavodsk 185910

sergey_kolomeychuk@rambler.ruhttps://orcid.org/0000-0003-2779-9046ПутиловА. А.PutilovA. A.

117485; г. Москва; Бутлерова; 5А

Arcady A. Putilov – Dr. Sc. (Biol.); Leading Researcher at the Laboratory of Sleep/Wake Neurobiology

Butlerova 5A; Moscow 117485

putilov@google.comhttps://orcid.org/0000-0003-2088-5101МейгалА. Ю.MeigalA. Yu.

185910; г. Петрозаводск; пр. Ленина; 33

Alexander Y. Meigal – Dr. Sc. (Med.); Head of the Laboratory of the New Methods in Physiological Research

Prosp. Lenina; 33; Petrozavodsk 185910

meigal@petrsu.ruhttps://orcid.org/0000-0001-7840-939XМорозовА. В.MorozovA. V.

185910; г. Петрозаводск; ул.; Пушкинская 11

Artem V. Morozov – leading biologist at the Laboratory of Animal Ecophysiology

Pushkinskaya str.; 11; Petrozavodsk 185910

artem.morozow@yandex.ruhttps://orcid.org/0000-0002-4975-5821БудкевичЕ. В.BudkevichE. V.

355017; г. Ставрополь Пушкина ул.; 1

Elena V. Budkevich – Cand. Sc. (Med.); Leading Researcher at the “nanobiotechnology and biophysics” research laboratory

Pushkina str.; 1; Stavropol 355017

evbudkevich@ncfu.ruhttps://orcid.org/0000-0001-7471-4792МарковА. А.MarkovA. A.

625023; г. Тюмень; ул. Одесская; 54

Alexander A. Markov – Cand. Sc. (Med.); Director of the Research Institute of Biomedicine and Biomedical Technologies; Associate Professor of the Department of Medical Prevention and Rehabilitation

Odesskaya; 54; Tyumen 625023

markova@tyumsmu.ruhttps://orcid.org/0000-0003-2028-1033ГубинД. Г.GubinD. G.

625023; г. Тюмень; ул. Одесская; 54,

625026; г. Тюмень; ул. Мельникайте; 111

Denis G. Gubin – Dr. Sc. (Biol.); Head of the Laboratory of Chronobiology; Tyumen State Medical University; Leading Researcher; Tyumen Cardiology Research Center

Odesskaya; 54; Tyumen 625023,

Melnikaite str.; 111; Tyumen 625026

dgubin@mail.ruТюменский государственный медицинский университет; Институт биологии Карельского научного центра РАНTyumen State Medical University; Institute of Biology, Karelian Research Centre, Russian Academy of SciencesИнститут высшей нервной деятельности и нейрофизиологии РАНInstitute of Higher Nervous Activity and Neurophysiology of the Russian Academy of SciencesИнститут высоких биомедицинских технологий Петрозаводского государственного университетаInstitute of High Biomedical Technologies, Petrozavodsk State UniversityИнститут биологии Карельского научного центра РАНInstitute of Biology, Karelian Research Centre, Russian Academy of SciencesСеверо-Кавказский федеральный университетNorth Caucasus Federal UniversityТюменский государственный медицинский университетTyumen State Medical UniversityТюменский государственный медицинский университет; Тюменский кардиологический научный центрTyumen State Medical University ; Tyumen Cardiology Research Center202523092025104129139Copyright © Коломейчук С.Н., Путилов А.А., Мейгал А.Ю., Морозов А.В., Будкевич Е.В., Марков А.А., Губин Д.Г., 20252025Коломейчук С.Н., Путилов А.А., Мейгал А.Ю., Морозов А.В., Будкевич Е.В., Марков А.А., Губин Д.Г.Kolomeichuk S.N., Putilov A.A., Meigal A.Y., Morozov A.V., Budkevich E.V., Markov A.A., Gubin D.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/5560Введение

Введение. Занятия интенсивными аэробными упражнениями могут привести к специфическому; непатологическому состоянию; известному как изолированная систолическая гипертензия или «сердце спортсмена»; характеризующемуся повышенным систолическим артериальным давлением. Побочные эффекты реакции сердца на интенсивные тренировки могут быть обусловлены индивидуальными генетическими факторами.

Цель

Цель. Анализ минимального набора полиморфных вариантов генов в связи с индивидуальными различиями гемодинамических параметров у спортсменов и контрольной группы нетренированных лиц.

Методы

Методы. Критериям включения соответствовали 98 человек. В качестве испытуемых были отобраны лица мужского пола возраст 18–30 лет; профессионально занимающиеся спортом более 4 лет; без серьезных патологий. Участников разделяли на группы согласно основным типам спортивной специализации. Измерялись основные антропометрические параметры; а также оценено функциональное состояние сердечнососудистой системы в состоянии покоя. Генетический анализ проводился с использованием ДНК; выделенной из образцов крови. Варианты генов ACTN3; ACE; PPARA и BDKRB2; ассоциированные с развитием и функционированием сердца; изучали методом ПЦР. Статистический анализ проводился с использованием статистического пакета SPSS версия 22.0 (IBM; Armonk; США).

Результаты и обсуждение

Результаты и обсуждение. Были определены три полиморфных варианта генов (ACTN3 R577X; ACE I/D и BDKRB2 -9/+9); которые достоверно предсказывали значения систолического артериального давления. Полиморфные варианты генов ACE и BDKRB2 ассоциированы с высоким уровнем систолического артериального давления у спортсменов группы силовой направленности. Полиморфный вариант I/D гена ACE был дифференцированно связан с силовыми тренировками по сравнению с тренировками на скорость и выносливость. Сочетание доминантных аллелей четырех генов является предиктором повышенного систолического артериального давления у спортсменов силовой специализации.

Выводы

Выводы. Определенные варианты генов могут влиять на развитие специфических для тренировок и преимущественно неблагоприятных характеристик состава тела. Три полиморфных варианта генов могут независимо предсказывать ремоделирование сердца и будущие осложнения со здоровьем у молодых спортсменов.

Introduction

Introduction. Engaging in intense aerobic exercises can lead to a specific; nonpathological condition known as isolated systolic hypertension or “athlete’s heart”; characterized by elevated systolic blood pressure. The side effects of the heart’s response to intense training can be attributed to individual genetic factors.

The aim

The aim. To analyze a minimal set of polymorphic gene variants in relation to personal differences in hemodynamic parameters among athletes and a control group of untrained individuals.

Methods

Methods. The study cohort comprised 98 participants who met the specified inclusion criteria. All subjects were male individuals aged between 18 and 30 years; actively engaged in professional sports for a minimum of four years and free from serious medical conditions. Individuals were examined at Republican Autonomous Healthcare Institution of Karelia “Medical and Physical Education Dispensary” and grouped according to sports disciplines. Comprehensive measurements of key anthropometric parameters were conducted; along with an assessment of the functional state of the cardiovascular system at rest. The genetic analysis was performed using DNA extracted from blood samples. ACTN3; ACE; PPARA and BDKRB2 gene variants associated with heart development and functioning were studied by PCR. Statistical analysis was performed using the statistical package SPSS version 22.0 (IBM; Armonk; USA).

Results

Results. I/D ACE gene variant was distinctly associated with power-oriented training compared to speed-oriented and endurance-oriented athletes. The combination of dominant alleles from studied genes occurred to be predictor of higher systolic blood pressure in power-oriented athletes.

Conclusion

Conclusion. We found that genetic variants may affect to the development of training-specific and mostly disadvantageous characteristics of body composition. Three polymorphic gene variants could independently predict heart remodeling and future health complications in young athletes.

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The authors declare that there are no conflicts of interest present.