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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2025-10.4.2</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-5547</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКУШЕРСТВО И ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OBSTETRICS AND GYNAECOLOGY</subject></subj-group></article-categories><title-group><article-title>Прогнозирование риска развития инфильтративных форм генитального эндометриоза с поражением смежных органов</article-title><trans-title-group xml:lang="en"><trans-title>Predicting the risk of developing infiltrative forms of genital endometriosis with involvement of adjacent organs</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0357-7097</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баринов</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Barinov</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баринов Сергей Владимирович – доктор медицинских наук, профессор, заведующий кафедрой акушерства и гинекологии № 2</p><p>644099, Омская область, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>Sergey V. Barinov – Dr. Sc. (Med.), Professor, Head of the Department of Obstetrics and Gynecology No. 2</p><p>Lenina Str. 12, Omsk 644099</p></bio><email xlink:type="simple">barinov_omsk@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7200-7082</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мозговой</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Mozgovoi</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мозговой Сергей Игоревич – доктор медицинских наук, доцент, профессор кафедры патологической анатомии</p><p>644099, Омская область, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>Sergei I. Mozgovoi – Dr. Sc. (Med.), Associate Professor, Professor of the Department of Pathological Anatomy</p><p>Lenina Str. 12, Omsk 644099</p></bio><email xlink:type="simple">simozgovoy@yandex.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5365-7119</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тирская</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Tirskaya</surname><given-names>Yu. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тирская Юлия Игоревна – доктор медицинских наук, доцент, профессор кафедры акушерства и гинекологии № 2</p><p>644099, Омская область, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>Yuliya I. Tirskaya – Dr. Sc. (Med.), Associate Professor, Professor of the Department of Obstetrics and Gynecology No. 2</p><p>Lenina Str. 12, Omsk 644099</p></bio><email xlink:type="simple">yulia.tirskaya@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0895-4066</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазарева</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazareva</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лазарева Оксана Вячеславовна – кандидат медицинских наук, доцент кафедры акушерства и гинекологии № 2</p><p>644099, Омская область, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>Oksana V. Lazareva – Cand. Sc. (Med.), Associate Professor of the Department of Obstetrics and Gynecology No. 2</p><p>Lenina Str. 12, Omsk 644099</p></bio><email xlink:type="simple">lazow@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0348-5985</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кадцына</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kadtsyna</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кадцына Татьяна Владимировна – кандидат медицинских наук, доцент кафедры акушерства и гинекологии № 2</p><p>644099, Омская область, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>Tatyana V. Kadtsyna – Cand. Sc. (Med.), Associate Professor of the Department of Obstetrics and Gynecology No. 2</p><p>Lenina Str. 12, Omsk 644099</p></bio><email xlink:type="simple">tatianavlad@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2541-7091</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чуловский</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Tshulovsky</surname><given-names>Yu. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чуловский Юрий Игоревич – кандидат медицинских наук, доцент, доцент кафедры акушерства и гинекологии № 2</p><p>644099, Омская область, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>Yurij I. Tshulovsky – Cand. Sc. (Med.), Associate Professor of the Department of Obstetrics and Gynecology No. 2</p><p>Lenina Str. 12, Omsk 644099</p></bio><email xlink:type="simple">akusheromsk@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0433-8960</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хорошкин</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khoroshkin</surname><given-names>Ye. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хорошкин Егор Андреевич – ассистент кафедры акушерства и гинекологии № 2</p><p>644099, Омская область, г. Омск, ул. Ленина, 12</p></bio><bio xml:lang="en"><p>Yegor A. Khoroshkin – teaching assistant of the Department of Obstetrics and Gynecology No. 2</p><p>Lenina Str. 12, Omsk 644099</p></bio><email xlink:type="simple">drrussian@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6080-1828</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шкабарня</surname><given-names>Л. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Shkabarnya</surname><given-names>L. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шкабарня Людмила Леонидовна – заведующий отделением гинекологии</p><p>644111, Омская область, г. Омск, ул. Березовая, 3</p></bio><bio xml:lang="en"><p>Lyudmila L. Shkabarnya – Head of the Department of Gynecology, Perinatal Centre</p><p>Berezovaya St. 3, Omsk 644111</p></bio><email xlink:type="simple">l_shka@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-3824-8249</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эллерт</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Ellert</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эллерт Алёна Николаевна – врач-акушер-гинеколог отделения гинекологии</p><p>644111, Омская область, г. Омск, ул. Березовая, 3</p></bio><bio xml:lang="en"><p>Alyona N. Ellert – Obstetrician-Gynecologist of the Department of Gynecology</p><p>Berezovaya St. 3, Omsk 644111</p></bio><email xlink:type="simple">akusheromsk@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Омский Государственный Медицинский Университет» Минздрава России</institution></aff><aff xml:lang="en"><institution>Omsk State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Бюджетное учреждение здравоохранения Омской области «Областная клиническая больница»</institution></aff><aff xml:lang="en"><institution>Regional Clinical Hospital</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>23</day><month>09</month><year>2025</year></pub-date><volume>10</volume><issue>4</issue><fpage>12</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Баринов С.В., Мозговой С.И., Тирская Ю.И., Лазарева О.В., Кадцына Т.В., Чуловский Ю.И., Хорошкин Е.А., Шкабарня Л.Л., Эллерт А.Н., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Баринов С.В., Мозговой С.И., Тирская Ю.И., Лазарева О.В., Кадцына Т.В., Чуловский Ю.И., Хорошкин Е.А., Шкабарня Л.Л., Эллерт А.Н.</copyright-holder><copyright-holder xml:lang="en">Barinov S.V., Mozgovoi S.I., Tirskaya Y.I., Lazareva O.V., Kadtsyna T.V., Tshulovsky Y.I., Khoroshkin Y.A., Shkabarnya L.L., Ellert A.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/5547">https://www.actabiomedica.ru/jour/article/view/5547</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Эндометриоз сопровождается тазовой болью, дисменореей, диспареунией, бесплодием. Глубокий инфильтративый эндометриоз (ГИЭ) диагностируется с запозданием на 6–10 лет после появления первых симптомов.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Улучшить раннюю диагностику инфильтративных форм генитального эндометриоза с поражением смежных органов путем определения предикторов на основе математической модели прогноза риска заболевания.</p></sec><sec><title>Методы</title><p>Методы. Ретроспективно обследовано 67 пациенток с ГИЭ III-IV стадии по классификации rASRM, наблюдавшихся в перинатальном центре БУЗОО «ОКБ» за период с 2014 по 2023 гг.: 32 пациентки с прорастанием смежных органов (группа А), 35 пациенток без прорастания смежных органов эндометриозом (группа В). Оценивались жалобы, анамнез, данные осмотра, результаты лабораторных и инструментальных исследований.</p></sec><sec><title>Результаты</title><p>Результаты. У пациенток из группы А отмечалась большая выраженность тазовой боли (p &lt; 0,001) при оценке по ВАШ. Выявлена более длительная продолжительность жалоб у пациенток из основной группы (p &lt; 0,001). Диспареуния достоверно чаще встречалась у пациенток из группы А (р = 0,011). По данным УЗИ у пациенток из основной группы чаще выявлялись признаки аденомиоза (р &lt; 0,001), ретрофлексии матки (р = 0,005), инфильтрата в ретроцервикальной или предпузырной клетчатке (р &lt; 0,001). По данным МРТ в группе А чаще выявлялись признаки прорастания толстой кишки (р = 0,001) и влагалища (р = 0,015).</p></sec><sec><title>Заключение</title><p>Заключение. Основными предикторами поражения смежных органов генитальным инфильтративным эндометриозом являются: выраженность хронической тазовой боли в баллах по ВАШ 5 баллов и более (р = 0,003), наличие инфильтрата в ретроцервикальной или предпузырной клетчатке по данным УЗИ (р = 0,001), продолжительность жалоб 22 месяца и более (р = 0,002), наличие диспареунии (р = 0,015). Разработанная диагностическая модель обладает высокой чувствительностью (93,7 %), специфичностью (82,9 %) и подтверждена результатами ROC-анализа.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Backgorund</title><p>Backgorund. Women with endometriosis suffer from pelvic pain, dysmenorrhea, infertility. Deep infiltrating endometriosis (DIE) is diagnosed with a delay from 6 to 10 years after the first symptoms manifest.</p></sec><sec><title>The aim</title><p>The aim. To improve early diagnosis of DIE with adjacent organ involvement by identifying predictors based on a risk prediction model.</p></sec><sec><title>Methods</title><p>Methods. This retrospective comparative study included 67 patients with DIE stage III-IV according to the rASRM classification who were divided into 2 groups: group A – 32 patients with involvement of adjacent organs, group B – 35 patients without involvement of adjacent organs by endometriosis.</p></sec><sec><title>Results</title><p>Results. Patients from Group A had a greater severity of pelvic pain (p &lt; 0.001) when assessed via the VAS scale. Patients in Group A had a longer duration of complaints (p &lt; 0.001). Dyspareunia was more common in patients in Group A (p = 0.011). According to the ultrasound data, patients in Group A more often had signs of adenomyosis (p &lt; 0.001), retroflexion of the uterus (p = 0.005), retrocervical or prevesical infiltration (p &lt; 0.001). According to MRI data, Group A more often showed signs of colon (p = 0.001) and vaginal infiltration (p = 0.015).</p></sec><sec><title>Conclusions</title><p>Conclusions. The main predictive signs of DIE with involvement of adjacent organs were identified: severity of pelvic pain of 5 points (VAS) or more (p = 0.003), retrocervical or prevesical infiltration according to pelvic ultrasound (p = 0.001), duration of symptoms for 22 months or more (p = 0.002), dyspareunia (p = 0.015). We created a predictive model of DIE with involvement of adjacent organs (sensitivity 93.7 %, specificity 82.9 %) that was approved via ROC-analysis.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>эндометриоз</kwd><kwd>тазовая боль</kwd><kwd>магнитно-резонансная томография</kwd><kwd>ультразвуковое исследование</kwd><kwd>глубокий инфильтративный эндометриоз</kwd><kwd>поражение смежных органов</kwd><kwd>лапароскопия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>endometriosis</kwd><kwd>pelvic pain</kwd><kwd>magnetic resonance imaging</kwd><kwd>ultrasonography</kwd><kwd>deep infiltrating endometriosis</kwd><kwd>involvement of adjacent organs</kwd><kwd>laparoscopy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Burghaus S, Schäfer SD, Beckmann MW, Brandes I, Brünahl C, Chvatal R, et al. Diagnosis and treatment of endometriosis. 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