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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2025-10.2.15</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-5311</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕВРОЛОГИЯ И НЕЙРОХИРУРГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEUROLOGY AND NEUROSURGERY</subject></subj-group></article-categories><title-group><article-title>Основы персонифицированного подхода к профилактике инсульта у городских и сельских жителей субъекта Арктического макрорегиона</article-title><trans-title-group xml:lang="en"><trans-title>Basics of a personalized approach to stroke prevention in urban and rural residents of the Arctic macro-region</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6523-7071</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черных</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernykh</surname><given-names>E. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черных Екатерина Михайловна – аспирант кафедры семейной медицины и внутренних болезней</p><p>163000, г. Архангельск, пр. Троицкий, д. 51</p></bio><bio xml:lang="en"><p>Ekaterina M. Chernykh – graduate student of the Department of Family Medicine and Internal Diseases</p><p>Troitsky prospect, 51, Arkhangelsk 163000</p></bio><email xlink:type="simple">raduga0302@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0729-3726</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хасанова</surname><given-names>Н. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Khasanova</surname><given-names>N. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хасанова Нина Минувалиевна – кандидат медицинских наук, доцент кафедры семейной медицины и внутренних болезней</p><p>163000, г. Архангельск, пр. Троицкий, д. 51</p></bio><bio xml:lang="en"><p>Nina M. Khasanova – Cand. Sc. (Med.), Associate Professor of the Department of Family Medicine and Internal Diseases</p><p>Troitsky prospect, 51, Arkhangelsk 163000</p></bio><email xlink:type="simple">khasanovanina@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4458-8702</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карякин</surname><given-names>A. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Karyakin</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карякин Алексей Андреевич – кандидат технических наук, доцент, заведующий кафедрой медицинской и биологической физики</p><p>163000, г. Архангельск, пр. Троицкий, д. 51</p></bio><bio xml:lang="en"><p>Aleksey A. Karyakin – Cand. Sc. (Tech.), Associate professor, Head of the Department of Medical and Biological Physics</p><p>Troitsky prospect, 51, Arkhangelsk 163000                                                                                                     </p></bio><email xlink:type="simple">biophyzica@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0781-0164</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карякина</surname><given-names>О. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Karyakina</surname><given-names>O. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карякина Ольга Евгеньевна – кандидат биологических наук, доцент кафедры биологии человека и биотехнических систем</p><p>163002, г. Архангельск, наб. Северной Двины, д. 17</p></bio><bio xml:lang="en"><p>Olga E. Karyakina – Cand. Sc. (Bio.), Associate Professor of Department of Human Biology and Biotechnical Systems        </p><p> emb. Northern Dvina, 17, Arkhangelsk 163002            </p></bio><email xlink:type="simple">o.travnikova@narfu.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2281-0576</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попов</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Popov</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Попов Владимир Викторович – доктор медицинских наук, профессор, заведующий кафедрой семейной медицины и внутренних болезней</p><p>163000, г. Архангельск, пр. Троицкий, д. 51</p></bio><bio xml:lang="en"><p>Vladimir V. Popov – Dr. Sc. (Med.), Professor and Head of the Department of Family Medicine and Internal Diseases</p><p>Troitsky prospect, 51, Arkhangelsk 163000</p></bio><email xlink:type="simple">fmi2008@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Северный государственный медицинский университет</institution></aff><aff xml:lang="en"><institution>Northern State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Северный (Арктический) федеральный университет имени М.В. Ломоносова</institution></aff><aff xml:lang="en"><institution>M.V. Lomonosov Northern (Arctic) Federal University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>19</day><month>05</month><year>2025</year></pub-date><volume>10</volume><issue>2</issue><fpage>150</fpage><lpage>163</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Черных Е.М., Хасанова Н.М., Карякин A.А., Карякина О.Е., Попов В.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Черных Е.М., Хасанова Н.М., Карякин A.А., Карякина О.Е., Попов В.В.</copyright-holder><copyright-holder xml:lang="en">Chernykh E.M., Khasanova N.M., Karyakin A.A., Karyakina O.E., Popov V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/5311">https://www.actabiomedica.ru/jour/article/view/5311</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Стремление к достижению максимального результата при реализации программ по предупреждению острых цереброваскулярных заболеваний требует изучения факторов, определяющих различия в проводимых профилактических мероприятиях.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Изучить отличия в структуре типов инсульта и распространенности сопутствующих заболеваний у городских и сельских пациентов с инсультом, проживающих в Архангельской области с учетом стратификации по полу и возрасту.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведено ретроспективное исследование 5227 пациентов региональных сосудистых центров городской (РСЦ 1 ГКБ) (3588) и областной (РСЦ АОКБ) больниц (1639) в остром периоде инсульта, выписанных с января 2017 по декабрь 2020 г. Анализировали половозрастные характеристики, тип инсульта, структуру сопутствующих заболеваний, принадлежность к территории проживания.</p></sec><sec><title>Результаты</title><p>Результаты. Старшие возрастные группы более многочисленны среди городских пациентов (р &lt; 0,001), с преобладанием женщин старше 80 лет (р &lt; 0,001). В группе 50–69 лет у городских пациентов больше доля инсультов неуточненной этиологии (р &lt; 0,001), у областных – некардиоэмболических (атеротромботических, лакунарных) (р &lt; 0,001). Среди пациентов РСЦ 1 ГКБ больше лиц с наличием 5, 6 и 7 заболеваний (р &lt; 0,001; р &lt; 0,001 и р = 0,002). В группе старше 80 лет артериальная гипертензия (АГ), фибрилляция предсердий (ФП), ишемическая болезнь сердца (ИБС), хроническая сердечная недостаточность (ХСН), постинфарктный кардиосклероз (ПИКС), сахарный диабет (СД) (р &lt; 0,001) чаще встречались у городских пациенток. В группе 50–69 лет АГ, ЦА, ХСН (р &lt; 0,001), ИБС (р = 0,001) чаще регистрировались у пациенток областной больницы. Среди мужчин старше 70 лет АГ, СД, ФП, ПИКС (р &lt; 0,001), ЦА (р = 0,003), онкозаболевания (р = 0,007) чаще диагностировались у пациентов РСЦ 1 ГКБ. В группе 50–69 лет АГ, ИБС, ХСН (р &lt; 0,001) преобладали у областных пациентов-мужчин.</p></sec><sec><title>Заключение</title><p>Заключение. Понимание различий в структуре типов инсульта и распространенности сопутствующих заболеваний у городских и сельских пациентов с инсультом разных половозрастных групп, являются основанием для смещения акцентов при разработке профилактических мероприятий в исследуемом регионе.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. To achieve maximum results when preventing stroke requires studying the factors determining the difference in the preventive measures.</p></sec><sec><title>The aim</title><p>The aim. To study differences in the gender-age characteristics, stroke type structure and the prevalence of concomitant diseases in urban and rural patients with stroke living in the Arkhangelsk region.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The results of a retrospective study among 5227 patients with acute stroke discharged from City (3588) and Regional (1639) Hospitals are presented (January 2017 – December 2020). Gender-age, stroke types, presence and number of concomitant diseases, place of residence were analyzed.</p></sec><sec><title>Results</title><p>Results. Older age groups were more numerous in urban (p &lt; 0.001), with a predominance of women over 80 (p &lt; 0.001). In 50–69 group urban patients had more cryptogenic strokes (p &lt; 0.001), regional patients had more atherothrombotic and lacunar strokes (p &lt; 0.001). A higher comorbidity burden was found among urban (5, 6, 7 diseases) (p &lt; 0.001; p &lt; 0.001 and p = 0.002). In patients over 80, arterial hypertension (AH), atrial fibrillation (AF), coronary heart disease (CHD), chronic heart failure (CHF), post-infarction cardiosclerosis (PICS), diabetes mellitus (DM) (p &lt; 0.001) was more common in urban female. In 50–69 age women AH, CA, CHF (p &lt; 0.001) and CHD (p = 0.001) were more often in rural. Among men over 70 AH, DM, AF, PICS (p &lt; 0.001), CA (p = 0.003) and cancer (p = 0.007) were more often in urban. In 50–69 age men AH, CHD and CHF (p &lt; 0.001) predominated in rural.</p></sec><sec><title>Conclusion</title><p>Conclusion. The identified differences determine the basis for a shift in emphasis in the development of preventive measures in the region under study.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>профилактика инсульта</kwd><kwd>городские и сельские пациенты с инсультом</kwd><kwd>сопутствующие инсульту заболевания</kwd><kwd>Арктический макрорегион</kwd></kwd-group><kwd-group xml:lang="en"><kwd>stroke prevention</kwd><kwd>urbanandruralpatients</kwd><kwd>diseases associatedwith stroke</kwd><kwd>Arctic macro-region</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">GBD 2021 Stroke Risk Factor Collaborators. Global, regional, and national burden of stroke and its risk factors, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. 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