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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2025-10.2.11</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-5307</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КАРДИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CARDIOLOGY</subject></subj-group></article-categories><title-group><article-title>Характеристика пациентов с хронической сердечной недостаточностью с умеренно сниженной фракцией выброса: клинико-демографический аспект</article-title><trans-title-group xml:lang="en"><trans-title>Characteristics of patients with chronic heart failure with mildly reduced ejection fraction: clinical and demographic aspect</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0813-4719</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дуйшеналиева</surname><given-names>М. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Duishenalieva</surname><given-names>M. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дуйшеналиева Мыскал Туратбековна – научный сотрудник, заведующая отделением Артериальных гипертензий </p><p>720040, г. Бишкек, ул. Тоголока Молдо, 3</p></bio><bio xml:lang="en"><p>Elzira Zh. Myrzabekova – Junior Researcher, Department of Arterial Hypertension</p><p>Togolok Moldo str., 3, 720040, Bishkek</p></bio><email xlink:type="simple">dmyskal@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4621-3939</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Полупанов</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Polupanov</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Полупанов Андрей Геннадьевич – доктор медицинских наук, профессор, г.н.с. отделения Артериальных гипертензий, Национальный центр кардиологии и терапии имени академика М. Миррахимова при Министерстве Здравоохранения Кыргыстана; заведующий кафедрой пропедевтики внутренних болезней с курсом эндокринологии, Кыргызская Государственная Медицинская Академия имени И.К. Ахунбаева</p><p>720040, г. Бишкек, ул. Тоголока Молдо, 3; 720040, г. Бишкек, ул. Тоголока Молдо, 3</p></bio><bio xml:lang="en"><p>Andrey G. Polupanov – Dr. Sc. (Med), Prof., Senior researcher of the Arterial Hypertension Department, National Center of Cardiology and Internal Medicine named after academician M. Mirrakhimov under the Ministry of Health of the Kyrgyz Republic; head of the Department of propaedeutics of internal diseases with course of endocrinology, Kyrgyz State Medical Academy named after I.K. Akhunbaev</p><p>Togolok Moldo str., 3, 720040, Bishkek; Akhunbaev str., 92, 720020, Bishkek</p></bio><email xlink:type="simple">polupanov_72@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0856-2230</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рысматова</surname><given-names>Ф. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Rysmatova</surname><given-names>F. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рысматова Флора Таштемировна – кандидат медицинских наук., заведующая кафедрой внутренних болезней с курсом семейной медицины, медицинский факультет</p><p>720040, г. Бишкек, ул. Тоголока Молдо, 3</p></bio><bio xml:lang="en"><p>Flora T. Rysmatova – Cand. Sc. (Med), Head of the Department of Internal Medicine with a course in Family Medicine, Faculty of Medicine</p><p>Lenin Ave., 331, Osh</p></bio><email xlink:type="simple">frysmatova@oshsu.kg</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1584-9050</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мырзабекова</surname><given-names>Э. Ж.</given-names></name><name name-style="western" xml:lang="en"><surname>Myrzabekova</surname><given-names>E. Zh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мырзабекова Эльзира Жумгалбековна – младший научный сотрудник отделения Артериальных гипертензий</p><p>720040, г. Бишкек, ул. Тоголока Молдо, 3</p></bio><bio xml:lang="en"><p>Elzira Zh. Myrzabekova – Junior Researcher, Department of Arterial Hypertension</p><p>Togolok Moldo str., 3, 720040, Bishkek</p></bio><email xlink:type="simple">elzira.96@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эсенбекова</surname><given-names>Н. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Esenbekova</surname><given-names>N. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эсенбекова Нуркан Эсенбековна – младший научный сотрудник отделения Артериальных гипертензий</p><p>720040, г. Бишкек, ул. Тоголока Молдо, 3</p></bio><bio xml:lang="en"><p>Nurkan E. Esenbekova – Junior Researcher, Department of Arterial Hypertension</p><p>Togolok Moldo str., 3, 720040, Bishkek</p></bio><email xlink:type="simple">esenbekovanurkan@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-0190-4179</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чолпонбекова</surname><given-names>Н. Ч.</given-names></name><name name-style="western" xml:lang="en"><surname>Cholponbekova</surname><given-names>N. Ch.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чолпонбекова Назгуль Чолпонбековна – младший научный сотрудник отделения Артериальных гипертензий</p><p>720040, г. Бишкек, ул. Тоголока Молдо, 3</p></bio><bio xml:lang="en"><p>Nazgul Ch. Cholponbekova–Junior Researcher,Department of Arterial Hypertension</p><p>Togolok Moldo str., 3, 720040, Bishkek</p></bio><email xlink:type="simple">nazgulcholponbekova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-1103-5425</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алтымышова</surname><given-names>Э. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Altymyshova</surname><given-names>E. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алтымышова Эльсинора Шакировна – младший научный сотрудник отделения Артериальных гипертензий</p><p>720040, г. Бишкек, ул. Тоголока Молдо, 3</p></bio><bio xml:lang="en"><p>Elsinora Sh. Altymyshova – Junior Researcher, Department of Arterial Hypertension</p><p>Togolok Moldo str., 3, 720040, Bishkek</p></bio><email xlink:type="simple">elsinora1995@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5727-537X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Арыкова</surname><given-names>А. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Arykova</surname><given-names>A. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Арыкова Айдана Таалайбековна – преподаватель кафедры Терапии № 2 специальности «Лечебное дело»</p><p>720000, г. Бишкек, ул. Киевская, 44</p></bio><bio xml:lang="en"><p>Aidana T. Arykova – teacher of the Department of Therapy No. 2, specialty “General Medicine</p><p>Kiev str, 44, Bishkek, 720000</p></bio><email xlink:type="simple">arykova.aidana98@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6429-260X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ческидова</surname><given-names>Н. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Cheskidova</surname><given-names>N. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ческидова Наталья Борисовна – кандидат медицинских наук, старший научный сотрудник отделения Артериальных гипертензий</p><p>720040, г. Бишкек, ул. Тоголока Молдо, 3</p></bio><bio xml:lang="en"><p>Nataliya B. Cheskidova – Cand. Sc. (Med.), Senior researcher, Department of Arterial Hypertension</p><p>Togolok Moldo str., 3, 720040, Bishkek</p></bio><email xlink:type="simple">cheskidova_natal@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0654-5963</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джишамбаев</surname><given-names>Э. Дж.</given-names></name><name name-style="western" xml:lang="en"><surname>Djyshambaev</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Джишамбаев Эрнест Джумакадырович – доктор медицинских наук, профессор, заведующий отделением Нарушений ритма сердца</p><p>720040, г. Бишкек, ул. Тоголока Молдо, 3</p></bio><bio xml:lang="en"><p>Ernest D. Djyshambaev – Dr. Sc. (Med), Prof., Head of the Department of Heart Rhythm Disorders</p><p>Togolok Moldo str., 3, 720040, Bishkek</p></bio><email xlink:type="simple">ernestdd1958@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный центр кардиологии и терапии имени академика М. Миррахимова</institution></aff><aff xml:lang="en"><institution>National Center of Cardiology and Internal Medicine named after academician M. Mirrakhimov</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный центр кардиологии и терапии имени академика М. Миррахимова; &#13;
Кыргызская Государственная Медицинская Академия имени И.К. Ахунбаева</institution></aff><aff xml:lang="en"><institution>National Center of Cardiology and Internal Medicine named after academician M. Mirrakhimov; &#13;
Kyrgyz State Medical Academy named after I.K. Akhunbaev</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Ошский Государственный Университет</institution></aff><aff xml:lang="en"><institution>Osh State University</institution></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Кыргызско-Российский Славянский Университет имени Б.Н. Ельцина</institution></aff><aff xml:lang="en"><institution>Kyrgyz-Russian Slavic University named after B.N. Yeltsin</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>19</day><month>05</month><year>2025</year></pub-date><volume>10</volume><issue>2</issue><fpage>109</fpage><lpage>118</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Дуйшеналиева М.Т., Полупанов А.Г., Рысматова Ф.Т., Мырзабекова Э.Ж., Эсенбекова Н.Э., Чолпонбекова Н.Ч., Алтымышова Э.Ш., Арыкова А.Т., Ческидова Н.Б., Джишамбаев Э.Д., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Дуйшеналиева М.Т., Полупанов А.Г., Рысматова Ф.Т., Мырзабекова Э.Ж., Эсенбекова Н.Э., Чолпонбекова Н.Ч., Алтымышова Э.Ш., Арыкова А.Т., Ческидова Н.Б., Джишамбаев Э.Д.</copyright-holder><copyright-holder xml:lang="en">Duishenalieva M.T., Polupanov A.G., Rysmatova F.T., Myrzabekova E.Z., Esenbekova N.E., Cholponbekova N.C., Altymyshova E.S., Arykova A.T., Cheskidova N.B., Djyshambaev E.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/5307">https://www.actabiomedica.ru/jour/article/view/5307</self-uri><abstract><sec><title>Введение</title><p>Введение. Сравнительно недавно был выделен новый класс хронической сердечной недостаточности (ХСН) — сердечная недостаточность с умеренно сниженной фракцией выброса левого желудочка (СНунФВ). Детерминанты и исходы этого фенотипа продолжают уточняться.</p></sec><sec><title>Цель</title><p>Цель. Изучение клинико-демографических характеристики пациентов со СНунФВ. </p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведен ретроспективный анализ 1141 истории болезней пациентов с ХСН, находившихся на стационарном лечении в Национальном центре кардиологии и терапии имени М. Миррахимова: 39,4 %, 23,3 % и 37,3 % пациентов с ХСН, низкой СНнФВ, умеренно сниженной и сохраненной фракцией выброса (СНсФВ) левого желудочка соответственно. У всех пациентов оценивали демографические показатели, причины и тяжесть ХСН, факторы риска и сопутствующие заболевания.</p></sec><sec><title>Результаты</title><p>Результаты. Пациенты с СНунФВ по демографическим характеристикам и этиологии были сопоставимы с пациентами со СНнФВ, среди них преобладали мужчины (62 %), средний возраст составлял 63,9 лет. Наиболее частыми причинами СНунФВ выступали ишемическая болезнь сердца (ИБС) — 78,1 %, артериальная гипертензия (АГ) — 7,3 % и их сочетание — 22,1 %. Встречаемость ожирения, фибрилляции предсердий в группе СНунФВ составила 35,3 %, 28,6 % соответственно и не различалась по сравнению с больными СНнФВ. Значимо низкая распространенность хронической болезни почек и хронической обструктивной болезни легких наблюдалась среди больных СНунФВ и СНсФВ по сравнению с группой СНнФВ. Сахарный диабет 2 типа встречался у каждого пятого пациента независимо от фенотипа ХСН. Пациенты с III функциональным классом преобладали среди больных с СНунФВ (54,5 %) и СНнФВ (56,3 %).</p></sec><sec><title>Заключение</title><p>Заключение. Пациенты со СНунФВ по большинству клинико-демографических характеристик и тяжести течения ХСН были сопоставимы с пациентами группы СНнФВ.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. A new class of chronic heart failure (CHF) has been identified recently – heart failure with mildly reduced left ventricular ejection fraction (HFmrEF). The determinants and outcomes of this phenotype are still being clarified.</p></sec><sec><title>The aim</title><p>The aim. To study the clinical and demographic characteristics of patients with HFmrEF. </p></sec><sec><title>Materials and methods</title><p>Materials and methods. A retrospective analysis of 1141 medical records of patients with CHF who were hospitalized at the National Center of cardiology and Internal medicine named after M. Mirrakhimov were conducted. Patients were categorized as follows: 39.4 %, 23.3 % and 37.3 % of patients with CHF with low, mildly reduced and preserved left ventricular ejection fraction, respectively. Demographic indicators, causes and severity of CHF, risk factors, and comorbidities were assessed in all patients.</p></sec><sec><title>Results</title><p>Results. Patients with HFmrEF were comparable to those with HFrEF in terms of demographic characteristics and etiology. Among HFmrEF patients, men predominated (62 %), with an average age of 63,9 years. The most common causes of HFmrEF were coronary heart disease (CHD) (81,6 %), hypertension (7,3 %) and their combination (22,1 %). The incidence of obesity and atrial fibrillation in the HFmrEF group was 35,3 % and 28,6 %, respectively, and did not differ significantly from that in patients with HFrEF. A significantly lower prevalence of chronic kidney disease and chronic obstructive pulmonary disease was observed in the HFmrEF and HFpEF groups compared to the HFrEF group. Type 2 diabetes mellitus was present in approximately one in five patients, regardless of the CHF phenotype. Patients with functional class III (NYHA) predominated among those with HFmrEF (54,5 %) and HFrEF (56,3 %).</p></sec><sec><title>Conclusion</title><p>Conclusion. Patients with HFmrEF were comparable to those with HFrEF in most clinical and demographic characteristics and in the severity of CHF.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>хроническая сердечная недостаточность</kwd><kwd>фракция выброса</kwd><kwd>фенотип</kwd><kwd>СНунФВ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>chronic heart failure</kwd><kwd>ejection fraction</kwd><kwd>phenotype</kwd><kwd>HFmrEF</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Katsi V, Georgiopoulos G, Laina A, Koutli E, Parissis J, Tsioufis C, et al. Left ventricular ejection fraction as therapeutic target: is it the ideal marker? Heart Fail Rev. 2017; 22(6): 641-655. doi: 10.1007/s10741-017-9624-5</mixed-citation><mixed-citation xml:lang="en">Katsi V, Georgiopoulos G, Laina A, Koutli E, Parissis J, Tsioufis C, et al. 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