actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.29413/ABS.2025-10.2.6actabiomedica-5302Research ArticleАКУШЕРСТВО И ГИНЕКОЛОГИЯOBSTETRICS AND GYNAECOLOGYЭндокринные химические дизрапторы и репродуктивное здоровье женщины. Обзор литературыEndocrine chemical disraptors and female reproductive health. Literature reviewhttps://orcid.org/0000-0001-7014-6492АртымукН. B.ArtymukN. V.

Артымук Наталья Владимировна – доктор медицинских наук, профессор, заведующая кафедрой акушерства и гинекологии им. проф. Г.А. Ушаковой 

650056, Кемеровская область–Кузбасс, г. Кемерово, ул. Ворошилова, д. 22 А

Natalia V. Artymuk – Dr. Sc. (Med.), Professor, Head of the G.A. Ushakova Department of Obstetrics and Gynecology 

Voroshilova str., 22 A, 650056 Kemerovo region – Kuzbass, Kemerovo

artymuk@gmail.comhttps://orcid.org/0000-0001-5570-1988НовиковаО. Н.NovikovaO. N.

 Новикова Оксана Николаевна – доктор медицинских наук, профессор кафедры акушерства и гинекологии им. проф. Г.А. Ушаковой

650056, Кемеровская область–Кузбасс, г. Кемерово, ул. Ворошилова, д. 22 А

Oxana N. Novikova – Dr. Sc. (Med.), Professor of the G.A. Ushakova Department of Obstetrics and Gynecology

Voroshilova str., 22 A, 650056 Kemerovo region – Kuzbass, Kemerovo

oxana777_07@mail.ruhttps://orcid.org/0000-0003-3871-5450БегловД. Е.BeglovD. E.

Беглов Дмитрий Евгеньевич – министр здравоохранения Кемеровской области – Кузбасса

650064, Кемерово, пр. Советский, 58

Dmitriy E. Beglov – Minister of Health of the Kemerovo Region – Kuzbass

pr. Soviet, 58, 650064 

 

beglik@gmail.comФГБОУ ВО «Кемеровский государственный медицинский университет» Минздрава РоссииKemerovo State Medical UniversityМинистерство здравоохранения Кемеровской области – КузбассаMinistry of Health of the Kemerovo Region – Kuzbass2025190520251025767Copyright © Артымук Н.B., Новикова О.Н., Беглов Д.Е., 20252025Артымук Н.B., Новикова О.Н., Беглов Д.Е.Artymuk N.V., Novikova O.N., Beglov D.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/5302

В работе представлены данные систематических обзоров и метаанализов, посвященных проблеме влияния эндокринных химических дизрапторов (ЭХД) на репродуктивное здоровье женщин. ЭХД определяются как экзогенные химические вещества или комбинации химических веществ, которые влияют на любой аспект действия гормонов и вызывающие неблагоприятные последствия для здоровья интактного организма и/или его потомства в результате изменений эндокринной функции. В настоящее время раскрыты механизмы неблагоприятного воздействия многих ЭХД. Предполагается, что ЭХД могут действовать как агонисты или антагонисты стероидов, связываясь с рецепторами половых стероидов. ЭХД могут также действовать посредством негеномных механизмов путем блокирования рецепторов, связанных с G-белком. Наконец, вмешательство в действие стероидов может способствовать возникновению воспаления посредством различных механизмов, включая неспособность ограничить выработку активных форм кислорода. Этот систематический обзор содержит наиболее актуальные данные за последние 5 лет о неблагоприятном влиянии ЭХД на здоровье женщины и ее ребенка. Проведена оценка информационных баз данных Cochrane, MEDLINE, PubMed. Глубина поиска составила 5 лет.

The review presents data from systematic reviews and metaanalyses addressing the issue of the eff ts of endocrine chemical disraptors (ECDs) on women’s reproductive health. ECDs are defi  as exogenous chemicals or combinations of chemicals that aff t any aspect of hormone action and cause adverse health eff ts to the intact organism and/or its off        as a result of changes in endocrine function. Currently, the mechanisms of adverse eff ts of many ECDs have been disclosed. It is suggested that ECDs can act as steroid agonists or antagonists by binding to sex steroid receptors. ECDs may also act through non-genomic mechanisms by blocking G protein-coupled receptors. Finally, interference with the action of steroids can contribute to infl       through various mechanisms, including the inability to limit the production of reactive oxygen species. This systematic review was contains the most relevant data over the past 5 years on the adverse eff  ts of ECD on the health of a woman and her child. Cochrane, MEDLINE, PubMed information bases were evaluated.

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The authors declare that there are no conflicts of interest present.