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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2024-9.5.5</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-5033</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКУШЕРСТВО И ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OBSTETRICS AND GYNAECOLOGY</subject></subj-group></article-categories><title-group><article-title>Оценка клинического течения гипертензивных расстройств на фоне субклинического гипотиреоза у беременных женщин в Андижанской области</article-title><trans-title-group xml:lang="en"><trans-title>Evaluation of the clinical course of hypertensive disorders against the background of subclinical hypothyroidism in pregnant women</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-0366-3690</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Усманова</surname><given-names>М. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Usmanova</surname><given-names>M. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Усманова Мохинур Дилшод кизи – базовый докторант по акушерству и гинекологии</p><p>170100, г. Андижан, ул. Ю. Отабекова, 1</p></bio><bio xml:lang="en"><p>Mokhinur D. Usmanova – PhD Student in Obstetrics and Gynecology</p><p>Yu. Otabekova str. 1, Andijan 170100</p></bio><email xlink:type="simple">moxi.noral1221@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5522-793X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Насирова</surname><given-names>Ф. Ж.</given-names></name><name name-style="western" xml:lang="en"><surname>Nasirova</surname><given-names>F. Zh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Насирова Феруза Жумабаевна – кандидат медицинских наук, научный консультант кафедры акушерства и гинекологии № 1</p><p>170100, г. Андижан, ул. Ю. Отабекова, 1</p></bio><bio xml:lang="en"><p>Feruza Zh. Nasirova – Cand. Sc. (Med.), Scientific Consultant at the Department of Obstetrics and Gynecology No. 1</p><p>Yu. Otabekova str. 1, Andijan 170100</p></bio><email xlink:type="simple">f.jumabaevna69@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1005-8719</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Усманов</surname><given-names>Ш. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Usmanov</surname><given-names>Sh. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Усманов Шохрух Кутбидин угли – ментор, аналитик в программе прикладной эпидемиологии в Центральной Азии CDC</p><p>170100, г. Андижан, ул. Ю. Отабекова, 1</p></bio><bio xml:lang="en"><p>Shokhrukh K. Usmanov – Mentor, Analyst in the CDC Central Asia Field Epidemiology Training Program</p><p>Yu. Otabekova str. 1, Andijan 170100</p></bio><email xlink:type="simple">shohrux1718@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Андижанский государственный медицинский институт</institution></aff><aff xml:lang="en"><institution>Andijan State Medical Institute</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>22</day><month>11</month><year>2024</year></pub-date><volume>9</volume><issue>5</issue><fpage>43</fpage><lpage>52</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Усманова М.Д., Насирова Ф.Ж., Усманов Ш.К., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Усманова М.Д., Насирова Ф.Ж., Усманов Ш.К.</copyright-holder><copyright-holder xml:lang="en">Usmanova M.D., Nasirova F.Z., Usmanov S.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/5033">https://www.actabiomedica.ru/jour/article/view/5033</self-uri><abstract><p>Обоснование. Гипертензивные расстройства во время беременности, такие как гестационная гипертензия и преэклампсия, являются значимым риском для здоровья. Они требуют индивидуализированного подхода к лечению из-за многофакторной природы. Присутствие субклинического гипотиреоза может усилить эти риски, что делает мониторинг функции щитовидной железы до и во время беременности особенно важным.Цель исследования. Исследование клинических признаков и тяжести гипертензии при впервые выявленном субклиническом гипотиреозе у женщин в Андижане.Методы. В кейс-контрольном исследовании, проведённом с ноября 2022 г. по апрель 2023 г., участвовали 272 беременные женщины в возрасте от 18 до 40 лет без хронических заболеваний. В основную группу были включены 88 женщин, у которых гипертензия была диагностирована после 20-й недели беременности. Контрольную группу составили 184 женщины без гипертензии. Исследование исключало ВИЧ-положительных женщин, а также женщин с врождёнными аномалиями или перенёсшими хирургические вмешательства на органах мочеполовой и сердечно-сосудистой систем. Были изучены социально-демографические и жизненные характеристики участниц исследования. Анализ показал значимые различия в возрасте, уровне активности, месте жительства, занятости и образовании, а также выявил связь между индексом массы тела, состоянием здоровья и тяжестью гипертензии.Результаты. Исследование подчеркнуло важность контроля функции щитовидной железы во время беременности, связав гипертензию с возрастом, уровнем активности и ожирением. Это подтверждает необходимость комплексного подхода к ведению беременности, включая контроль тиреоидной функции и изменение образа жизни.</p></abstract><trans-abstract xml:lang="en"><p>Background. Hypertensive disorders during pregnancy, such as gestational hypertension and preeclampsia, pose significant health risks. They require a personalized treatment approach due to their multifactorial nature. The presence of subclinical hypothyroidism may exacerbate these risks, making thyroid function monitoring before and during pregnancy particularly important.The aim. To investigate the clinical features and severity of hypertension in newly diagnosed subclinical hypothyroidism among women in Andijan.Methods. A case-control study conducted from November 2022 to April 2023 included 272 pregnant women aged 18 to 40 years without chronic diseases. The main group comprised 88 women diagnosed with hypertension after the 20th week of pregnancy. The control group consisted of 184 women without hypertension. The study excluded HIV-positive women, as well as those with congenital anomalies or who had undergone surgical interventions on the genitourinary and cardiovascular systems. Socio-demographic and lifestyle characteristics of the participants were studied. The analysis revealed significant differences in age, activity level, place of residence, employment, and education, as well as a correlation between body mass index, health status, and hypertension severity.Results. The findings underscored the importance of thyroid function monitoring during pregnancy, linking hypertension to age, activity level, and obesity. This confirms the necessity for a comprehensive approach to pregnancy management, including thyroid function and lifestyle modifications.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гипотиреоз</kwd><kwd>гипертония</kwd><kwd>беременность</kwd><kwd>кейс-контрольное исследование</kwd><kwd>тиреоидные гормоны</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypothyroidism</kwd><kwd>hypertension</kwd><kwd>pregnancy</kwd><kwd>case control</kwd><kwd>thyroid hormones</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование финансировалось Андижанским государственным медицинским институтом Республики Узбекистан через базовую докторскую программу в виде исследовательской стипендии, покрывающей все расходы на организацию, сбор и анализ данных, а также публикацию результатов.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bell MJ. 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