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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2024-9.5.2</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-5029</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДИСКУССИОННЫЕ СТАТЬИ, ЛЕКЦИИ, НОВЫЕ ТРЕНДЫ МЕДИЦИНСКОЙ НАУКИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>DISCUSSION PAPERS, LECTURES, NEW TRENDS IN MEDICAL SCIENCE</subject></subj-group></article-categories><title-group><article-title>Перспективы использования искусственного интеллекта в фармакогенетических исследованиях: литературный обзор</article-title><trans-title-group xml:lang="en"><trans-title>Artificial intelligence in pharmacogenetics: A narrative review of current and future applications</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7374-2660</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абдуллаев</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Abdullaev</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абдуллаев Мусалитдин Абсаламович – ассистент кафедры фармакологии</p><p>414000, г. Астрахань, ул. Бакинская, 121</p></bio><bio xml:lang="en"><p>Musalitdin A. Abdullaev – Teaching Assistant at the Department of Pharmacology</p><p>Bakinskaya str. 121, Astrakhan 414000</p></bio><email xlink:type="simple">abdullaev-musalitdin@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3278-2556</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кантемирова</surname><given-names>Б. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kantemirova</surname><given-names>B. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кантемирова Бэла Исмаиловна – доктор медицинских наук, доцент, профессор кафедры фармакологии</p><p>414000, г. Астрахань, ул. Бакинская, 121</p></bio><bio xml:lang="en"><p>Bela I. Kantemirova – Dr. Sc. (Med.), Docent, Professor at the Department of Pharmacology</p><p>Bakinskaya str. 121, Astrakhan 414000</p></bio><email xlink:type="simple">belakantemirova@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4168-4851</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Башкина</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bashkina</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Башкина Ольга Александровна – доктор медицинских наук, профессор, заведующая кафедрой факультетской педиатрии, ректор</p><p>414000, г. Астрахань, ул. Бакинская, 121</p></bio><bio xml:lang="en"><p>Olga А. Bashkina – Dr. Sc. (Med.), Professor, Head of the Department of Faculty Pediatrics, Rector</p><p>Bakinskaya str. 121, Astrakhan 414000</p></bio><email xlink:type="simple">bashkina1@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5195-4301</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сычев</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sychev</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сычев Дмитрий Алексеевич – доктор медицинских наук, профессор, академик РАН, ректор</p><p>125993, г. Москва, ул. Баррикадная, 2/1</p></bio><bio xml:lang="en"><p>Dmitriy A. Sychev – Dr. Sc. (Med.), Professor, Member of the RAS, Rector</p><p>Barrikadnaya str. 2/1 build. 2</p></bio><email xlink:type="simple">dimasychev@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1614-7483</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванчук</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanchuk</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванчук Ольга Викторовна – доктор педагогических наук, доцент, заведующая кафедрой физики, математики и медицинской информатики</p><p>414000, г. Астрахань, ул. Бакинская, 121</p></bio><bio xml:lang="en"><p>Olga V. Ivanchuk – Dr. Sc. (Ed.), Docent, Head of the Department of Physics, Mathematics and Medical Informatics</p><p>Bakinskaya str. 121, Astrakhan 414000</p></bio><email xlink:type="simple">olgaiva.2401@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6564-3408</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Романова</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Romanova</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Романова Александра Николаевна – аспирант кафедры фармакологии</p><p>414000, г. Астрахань, ул. Бакинская, 121</p></bio><bio xml:lang="en"><p>Alexandra N. Romanova – Postgraduate at the Department of Pharmacology</p><p>Bakinskaya str. 121, Astrakhan 414000</p></bio><email xlink:type="simple">sasha.styles005@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Астраханский государственный медицинский университет» Минздрава России</institution></aff><aff xml:lang="en"><institution>Astrakhan State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuing Professional Education</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>21</day><month>11</month><year>2024</year></pub-date><volume>9</volume><issue>5</issue><fpage>12</fpage><lpage>21</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Абдуллаев М.А., Кантемирова Б.И., Башкина О.А., Сычев Д.А., Иванчук О.В., Романова А.Н., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Абдуллаев М.А., Кантемирова Б.И., Башкина О.А., Сычев Д.А., Иванчук О.В., Романова А.Н.</copyright-holder><copyright-holder xml:lang="en">Abdullaev M.A., Kantemirova B.I., Bashkina O.A., Sychev D.A., Ivanchuk O.V., Romanova A.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/5029">https://www.actabiomedica.ru/jour/article/view/5029</self-uri><abstract><p>На сегодняшний день задачей фармакогенетики является изучение корреляции между генетическими особенностями пациента и эффективностью лекарственных средств с одновременной оценкой рисков развития побочных реакций. Проведение фармакогенетических исследований требует применения сложных методик статистической обработки результатов, и всё чаще для подобного рода анализа применяются возможности искусственного интеллекта (ИИ). Искусственный интеллект – это современная технология, которая применяется с целью автоматизации выполнения задач, обычно требующих больших трудозатрат с использованием человеческого разума. Проведённый обзор научных исследований, посвящённых применению моделей машинного обучения в фармакогенетических исследованиях, показал, что искусственный интеллект представляет собой высокотехнологичный гибкий инструмент, способный обеспечить широкую имплементацию фармакогенетики в практическое здравоохранение. Перспективным направлением применения ИИ в фармакогенетике является внедрение технологии в выполнение задач по анализу, обнаружению, прогнозированию и поддержке фармакогенетической информации и систем принятия решений. Применение технологий глубокого обучения позволит расширить представление о фармакодинамике лекарственных средств, показаниях, противопоказаниях в назначении, что, возможно, приведёт к обновлению учебно-методической литературы по фармакологии и существенно продвинет качество фармакотерапии у пациентов. В то же время внедрение технологий ИИ может быть затруднительным ввиду некоторых факторов, таких как недостаток квалифицированных кадров, этические разногласия, сложности правового регулирования области. Несмотря на существующие проблемы, применение технологий ИИ в фармакогенетических исследованиях является высокоэффективным и целесообразным.</p></abstract><trans-abstract xml:lang="en"><p>Pharmacogenetics aims to investigate the correlation between patient genetic characteristics and the efficacy of pharmaceutical agents, while concurrently evaluating the risks of adverse reactions. This field of research necessitates the application of complex statistical analysis methodologies, and artificial intelligence (AI) capabilities are increasingly being leveraged for such analyses. AI represents an advanced technology employed to automate the execution of tasks that traditionally demand substantial human intellectual effort. A review of scientific literature on the application of machine learning models in pharmacogenetic research has demonstrated that AI is a highly sophisticated and flexible tool capable of facilitating the widespread implementation of pharmacogenetics in clinical practice. A promising area for the application of AI in pharmacogenetics involves the integration of this technology into tasks related to the analysis, detection, prediction, and support of pharmacogenetic information and decision-making systems. The utilization of deep learning technologies has the potential to expand the understanding of drug pharmacodynamics, indications, and contraindications, which may potentially lead to the updating of educational and methodological literature on pharmacology and substantially advance the quality of patient pharmacotherapy. However, the implementation of AI technologies may be hindered by factors such as a shortage of qualified personnel, ethical disagreements, and complexities in legal regulation of this domain. Nonetheless, the application of AI technologies in pharmacogenetic research demonstrates high effectiveness and expediency, despite the existing challenges.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фармакогенетика</kwd><kwd>искусственный интеллект</kwd><kwd>машинное обучение</kwd><kwd>фармакология</kwd><kwd>клиническая фармакология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pharmacogenetics</kwd><kwd>artificial intelligence</kwd><kwd>machine learning</kwd><kwd>pharmacology</kwd><kwd>pharmacy</kwd><kwd>clinical pharmacology</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Научное исследование выполнено в рамках реализации государственного задания Министерства здравоохранения Российской Федерации «Разработка алгоритмов персонализированного назначения антиагрегантов у пациентов с острым коронарным синдромом» (сроки реализации 2021–2023 гг.).</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Jordan MI, Mitchell TM. 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