<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2024-9.4.16</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-4955</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПСИХОЛОГИЯ И ПСИХИАТРИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PSYCHOLOGY AND PSYCHIATRY</subject></subj-group></article-categories><title-group><article-title>Деперсонализационно-дереализационный симптомокомплекс в клинике манифестных форм шизофрении</article-title><trans-title-group xml:lang="en"><trans-title>Depersonalization-derealization symptom complex in the clinic of manifest forms of schizophrenia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-8650-721X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лобков</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lobkov</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лобков Сергей Александрович – ассистент кафедры психиатрии и медицинской психологии</p><p>664003, г. Иркутск, ул. Красного Восстания, 1</p></bio><bio xml:lang="en"><p>Sergey A. Lobkov – Teaching Assistant at the Department of Psychiatry and Medical Psychology</p><p>Krasnogo Vosstaniya str. 1, Irkutsk 664003</p></bio><email xlink:type="simple">litetcover@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава России</institution></aff><aff xml:lang="en"><institution>Irkutsk State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>27</day><month>09</month><year>2024</year></pub-date><volume>9</volume><issue>4</issue><fpage>146</fpage><lpage>152</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лобков С.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Лобков С.А.</copyright-holder><copyright-holder xml:lang="en">Lobkov S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/4955">https://www.actabiomedica.ru/jour/article/view/4955</self-uri><abstract><sec><title>Актуальность</title><p>Актуальность. Вопросы ранней диагностики и превенции шизофрении, несмотря на более чем вековую историю изучения вопроса, сохраняют свою актуальность. В контексте верификации инициальных проявлений заболевания в последние десятилетия отмечается рост интереса к изучению деперсонализационно-дереализационного симптомокомплекса. Между тем, в МКБ-10 симптомы деперсонализации и дереализации не включены в ранг диагностически важных при данной патологии и традиционно рассматриваются как проявления нарушений шизотипического уровня. Имеющиеся противоречия предполагают необходимость дальнейшего изучения деперсонализации и дереализации в клинике манифестных форм шизофрении.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Оценка распространённости и клинических проявлений деперсонализации-дереализации в течение приступообразных форм шизофрении.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование включены 40 пациентов с симптомами деперсонализации-дереализации в клинической картине манифестных форм шизофрении. Типологические группы были представлены параноидной шизофренией с приступообразным либо непрерывным течением (18 человек), а также шизоаффективным расстройством (22 человека). Методы исследования: клинико-катамнестический, клинико-анамнестический, клинико-психопатологический методы; дополнительно использовалась Кембриджская шкала деперсонализации.</p></sec><sec><title>Результаты</title><p>Результаты. Проявления деперсонализации-дереализации на доманифестном этапе заболевания отмечались у 82,5 % исследуемого контингента. В большинстве случаев выявлялась лёгкая и средняя степень выраженности – у 37,5 и 42,5 % соответственно, тяжёлая степень обнаруживалась лишь у 20 % пациентов. В 17,5 % случаев проявления деперсонализации и дереализации носили периодический характер, а у большинства (65 % пациентов) – персистирующий. Почти у 1/3 больных деперсонализация была тотальной, у 22,5 % наблюдалась лишь аутопсихическая и аллопсихическая деперсонализация, и в 17,5 % случаев изолированно наблюдалась соматопсихическая деперсонализация. Обнаружена ассоциация степени выраженности деперсонализации-дереализации с параноидным синдромом. В течение заболевания, по мере нарастания негативных расстройств, проявления деперсонализации-дереализации редуцируются.</p></sec><sec><title>Заключение</title><p>Заключение. Полученные данные демонстрируют необходимость дальнейшего изучения деперсонализационного симптомокомплекса в клинике манифестных форм шизофрении в аспекте прогноза клинического течения заболевания.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. The issues of early diagnostics and prevention of schizophrenia, despite more than a century of their study, remain relevant. In recent decades, there has been an increase in interest in the study of depersonalization-derealization symptom complex in the context of verification of the initial manifestations of the disease. Meanwhile, ICD-10 does not include symptoms of depersonalization and derealization in the rank of diagnostically important symptoms for this pathology, and they are traditionally considered as manifestations of schizotypal disorders. The existing contradictions suggest the need for further study of depersonalization and derealization in the clinic of manifest forms of schizophrenia.</p></sec><sec><title>The aim of the study</title><p>The aim of the study. To assess the prevalence and clinical manifestations of depersonalization-derealization in paroxysmal forms of schizophrenia.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 40 patients with depersonalization-derealization symptoms in the clinical picture of manifest forms of schizophrenia. Typological groups were represented by paranoid schizophrenia with an attack-like or continuous course (18 people) and schizoaffective disorder (22 people). We used such research methods as clinical follow-up, clinical and anamnestic, clinical and psychopathological, and also the Cambridge Depersonalization Scale.</p></sec><sec><title>Results</title><p>Results. Manifestations of depersonalization-derealization at the pre-manifest stage of the disease were observed in 82.5 % of the study cohort. In most cases, mild and moderate severity was detected – in 37.5 and 42.5 %, respectively; severe form was found only in 20 % of patients. In 17.5 % of cases, manifestations of depersonalization and derealization were periodic, and in the majority (65 %) of patients they were persistent. Almost 1/3 of patients had total depersonalization, 22.5 % had only autopsychic and allopsychic depersonalization, and 17.5 % of cases had isolated somatopsychic depersonalization. An association was found between the severity of depersonalization-derealization and paranoid syndrome. During the disease, as negative disorders increase, the manifestations of depersonalization-derealization are reduced.</p></sec><sec><title>Conclusion</title><p>Conclusion. The obtained data demonstrate the need for further studying depersonalization symptom complex in the clinic of manifest forms of schizophrenia in the aspect of prognosis of the clinical course of the disease.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>расстройства самосознания</kwd><kwd>деперсонализация</kwd><kwd>дереализация</kwd><kwd>шизофрения</kwd><kwd>доманифестный этап</kwd></kwd-group><kwd-group xml:lang="en"><kwd>self-disorders</kwd><kwd>depersonalization</kwd><kwd>derealization</kwd><kwd>schizophrenia</kwd><kwd>premanifest stage</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Пятницкий Н.Ю. «Дефектная» и «функциональная» деперсонализации в концепции K. Haug. Психиатрия и психофармакотерапия. 2022; 24(1): 4-10.</mixed-citation><mixed-citation xml:lang="en">Pyatnitskiy NYu. "Defective" and "functional" depersonalization in the concept of K. Haug. Psychiatry and Psychopharmacotherapy. 2022; 24(1): 4-10. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Sar V, Alioğlu F, Akyuz G. Depersonalization and derealization in self-report and clinical interview: The spectrum of borderline personality disorder, dissociative disorders, and healthy controls. J Trauma Dissociation. 2017; 18(4): 490-506. doi: 10.1080/152997 32.2016.1240737</mixed-citation><mixed-citation xml:lang="en">Sar V, Alioğlu F, Akyuz G. Depersonalization and derealization in self-report and clinical interview: The spectrum of borderline personality disorder, dissociative disorders, and healthy controls. J Trauma Dissociation. 2017; 18(4): 490-506. doi: 10.1080/152997 32.2016.1240737</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Yang J, Millman LSM, David AS, Hunter ECM. The prevalence of depersonalization-derealization disorder: A systematic review. J Trauma Dissociation. 2023; 24(1): 8-41. doi: 10.1080/15299732.2 022.2079796</mixed-citation><mixed-citation xml:lang="en">Yang J, Millman LSM, David AS, Hunter ECM. The prevalence of depersonalization-derealization disorder: A systematic review. J Trauma Dissociation. 2023; 24(1): 8-41. doi: 10.1080/15299732.2 022.2079796</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Michal M, Beutel ME, Grobe TG. Wie oft wird die Depersonalisations-Derealisationsstörung (ICD-10: F48.1) in der ambulanten Versorgung diagnostiziert? Z Psychosom Med Psychother. 2010; 56(1): 74-83. (In German). doi: 10.13109/zptm.2010.56.1.74</mixed-citation><mixed-citation xml:lang="en">Michal M, Beutel ME, Grobe TG. Wie oft wird die Depersonalisations-Derealisationsstörung (ICD-10: F48.1) in der ambulanten Versorgung diagnostiziert? Z Psychosom Med Psychother. 2010; 56(1): 74-83. (In German). doi: 10.13109/zptm.2010.56.1.74</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Michal M, Adler J, Wiltink J, Reiner I, Tschan R, Wölfling K, et al. A case series of 223 patients with depersonalization-derealization syndrome. BMC Psychiatry. 2016; 16: 203. doi: 10.1186/ s12888-016-0908-4</mixed-citation><mixed-citation xml:lang="en">Michal M, Adler J, Wiltink J, Reiner I, Tschan R, Wölfling K, et al. A case series of 223 patients with depersonalization-derealization syndrome. BMC Psychiatry. 2016; 16: 203. doi: 10.1186/ s12888-016-0908-4</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Крылов В.И. Деперсонализационные расстройства (психопатологические особенности и систематика). Трудный пациент. 2019; 17(5): 43-49.</mixed-citation><mixed-citation xml:lang="en">Krylov VI. Deperosnalization disorders (psychopathologic features and systematization). Difficult Patient. 2019; 17(5): 43-49. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Sass L, Pienkos E, Nelson B, Medford N. Anomalous selfexperience in depersonalization and schizophrenia: A comparative investigation. Conscious Cogn. 2013; 22(2): 430-441. doi: 10.1016/ j.concog.2013.01.009</mixed-citation><mixed-citation xml:lang="en">Sass L, Pienkos E, Nelson B, Medford N. Anomalous selfexperience in depersonalization and schizophrenia: A comparative investigation. Conscious Cogn. 2013; 22(2): 430-441. doi: 10.1016/ j.concog.2013.01.009</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Feyaerts J, Sass L. Self-disorder in schizophrenia: A revised view (1. Comprehensive review-dualities of selfand worldexperience). Schizophr Bull. 2024; 50(2): 460-471. doi: 10.1093/ schbul/sbad169</mixed-citation><mixed-citation xml:lang="en">Feyaerts J, Sass L. Self-disorder in schizophrenia: A revised view (1. Comprehensive review-dualities of selfand worldexperience). Schizophr Bull. 2024; 50(2): 460-471. doi: 10.1093/ schbul/sbad169</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Parnas J, Handest P, Jansson L, Saebye D. Anomalous subjective experience among first-admitted schizophrenia spectrum patients: Empirical investigation. Psychopathology. 2005; 38(5): 259-267. doi: 10.1159/000088442</mixed-citation><mixed-citation xml:lang="en">Parnas J, Handest P, Jansson L, Saebye D. Anomalous subjective experience among first-admitted schizophrenia spectrum patients: Empirical investigation. Psychopathology. 2005; 38(5): 259-267. doi: 10.1159/000088442</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Parnas J, Henriksen MG. Disordered self in the schizophrenia spectrum: A clinical and research perspective. Harv Rev Psychiatry. 2014; 22(5): 251-265. doi: 10.1097/HRP.0000000000000040</mixed-citation><mixed-citation xml:lang="en">Parnas J, Henriksen MG. Disordered self in the schizophrenia spectrum: A clinical and research perspective. Harv Rev Psychiatry. 2014; 22(5): 251-265. doi: 10.1097/HRP.0000000000000040</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Srivastava A, Selloni A, Bilgrami ZR, Sarac C, McGowan A, Cotter M, et al. Differential expression of anomalous self-experiences in spontaneous speech in clinical high-risk and earlycourse psychosis quantified by natural language processing. Biol Psychiatry Cogn Neurosci Neuroimaging. 2023; 8(10): 1005-1012. doi: 10.1016/j.bpsc.2023.06.007</mixed-citation><mixed-citation xml:lang="en">Srivastava A, Selloni A, Bilgrami ZR, Sarac C, McGowan A, Cotter M, et al. Differential expression of anomalous self-experiences in spontaneous speech in clinical high-risk and earlycourse psychosis quantified by natural language processing. Biol Psychiatry Cogn Neurosci Neuroimaging. 2023; 8(10): 1005-1012. doi: 10.1016/j.bpsc.2023.06.007</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Sierra M, Berrios GE. The Cambridge Depersonalisation Scale: A new instrument for the measurement of depersonalization. Psychiatry Res. 2000; 93(2): 153-164. doi: 10.1016/s01651781(00)00100-1</mixed-citation><mixed-citation xml:lang="en">Sierra M, Berrios GE. The Cambridge Depersonalisation Scale: A new instrument for the measurement of depersonalization. Psychiatry Res. 2000; 93(2): 153-164. doi: 10.1016/s01651781(00)00100-1</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Лебедев С.В. Адаптация и психометрический анализ клинико-психопатологических методик самоотчета (опросников) на примере шкал деперсонализации. Вестник Московского университета. Серия 14: Психология. 2005; 4: 49-59.</mixed-citation><mixed-citation xml:lang="en">Lebedev SV. Adaptation and psychometric analysis of clinical and psychopathological self-report methods (questionnaires) using the example of depersonalization scales. Lomonosov Psychology Journal. 2005; 4: 49-59. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Дьяконов А.Л. Синдром деперсонализации при расстройствах шизофренического спектра. Психиатрия, психотерапия и клиническая психология. 2020; 11(2): 364-371. doi: 10.34883/PI.2020.11.2.013</mixed-citation><mixed-citation xml:lang="en">Dyakonov AL. Syndrome of depersonalization in disorders of schizophrenic spectrum. Psychiatry, Psychotherapy and Clinical Psychology. 2020; 11(2): 364-371. (In Russ.). doi: 10.34883/PI.2020.11.2.013</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Сергеев И.И., Басова А.Я. Бредовая деперсонализация. М.: Цифровичок; 2009.</mixed-citation><mixed-citation xml:lang="en">Sergeev II, Basova AYa, Sergeev II. Delusional depersonalization. Moscow: Tsifrovichok; 2009. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Басова А.Я. Бредовая деперсонализация: варианты, динамика, коморбидность: автореф. дис. … канд. мед. наук. М.; 2008.</mixed-citation><mixed-citation xml:lang="en">Basova AYa. Delusional depersonalization: Variants, dynamics, comorbidity: Abstract of the dissertation of Cand. Sc. (Med.). Moscow; 2008. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ануфриев А.К. О психопатологии начальных проявлений бредообразования. Независимый психиатрический журнал. 1992; 1-2: 14-24.</mixed-citation><mixed-citation xml:lang="en">Anufriev AK. On the psychopathology of the initial manifestations of delusional development. Independent Psychiatric Journal. 1992; 1-2: 14-24. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Смулевич А.Б. Лекции по психосоматике. М.; 2014.</mixed-citation><mixed-citation xml:lang="en">Smulevich AB. Lectures on psychosomatics. Moscow; 2014. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Parnas J, Handest P. Phenomenology of anomalous selfexperience in early schizophrenia. Compr Psychiatry. 2003; 44(2): 121-134. doi: 10.1053/comp.2003.50017</mixed-citation><mixed-citation xml:lang="en">Parnas J, Handest P. Phenomenology of anomalous selfexperience in early schizophrenia. Compr Psychiatry. 2003; 44(2): 121-134. doi: 10.1053/comp.2003.50017</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Huber G. Psychiatry. Lehrbuch fur Studium und Weiterbuildung. Schattaauer; 2004: 66-69. (In German).</mixed-citation><mixed-citation xml:lang="en">Huber G. Psychiatry. Lehrbuch fur Studium und Weiterbuildung. Schattaauer; 2004: 66-69. (In German).</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Haug K. Depersonalisation und Verwandte Erscheinungen. Handbuch der Geisteskrankheiten. Ergaenzungsband Teil 1. Berlin Heidelberg GMBH: Springer Verlag; 1939: 134-204. (In German). doi: 10.30629/2618-6667-2022-20-2-117-127</mixed-citation><mixed-citation xml:lang="en">Haug K. Depersonalisation und Verwandte Erscheinungen. Handbuch der Geisteskrankheiten. Ergaenzungsband Teil 1. Berlin Heidelberg GMBH: Springer Verlag; 1939: 134-204. (In German). doi: 10.30629/2618-6667-2022-20-2-117-127</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Нуллер Ю.Л., Михайленко И.И. Аффективные психозы. Л., 1988.</mixed-citation><mixed-citation xml:lang="en">Nuller YuL, Mikhailenko I.I. Affective psychoses. Leningrad; 1988. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Крылов В.И. Навязчивые состояния: тревожно-фобические и обсессивно-компульсивные расстройства. Ростов-на-Дону; 2016.</mixed-citation><mixed-citation xml:lang="en">Krylov VI. Obsessions: Phobic anxiety and obsessivecompulsive disorders. Rostov-on-Don; 2016. (In Russ.).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
