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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2024-9.4.5</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-4943</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВНУТРЕННИЕ БОЛЕЗНИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INTERNAL DISEASES</subject></subj-group></article-categories><title-group><article-title>Методика применения кардиореспираторного нагрузочного тестирования в медико-биологической практике (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Cardiopulmonary exercise test in medical and biological practice (literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5594-6624</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кирьянов</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Kiryanov</surname><given-names>A. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кирьянов Артем Борисович – ассистент кафедры биологии человека и биотехнических систем</p><p>163000, г. Архангельск, наб. Северной Двины, 17</p></bio><bio xml:lang="en"><p>Artyom B. Kiryanov – Teaching Assistant at the Department of Human Biology and Biotechnical Systems</p><p>Severnoy Dviny embankment 17, Arkhangelsk 163000</p></bio><email xlink:type="simple">a.kirjyanov@narfu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7194-9465</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кожевникова</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozhevnikova</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кожевникова Ирина Сергеевна – кандидат биологических наук, доцент кафедры биологии человека и биотехнических систем, ФГАОУ ВО «Северный (Арктический) федеральный университет имени М.В. Ломоносова»; старший научный сотрудник, заведующая лабораторией инновационных технологий, ФГБУН «Федеральный исследовательский центр комплексного изучения Арктики имени академика Н.П. Лаверова УрО РАН»; доцент кафедры гигиены и медицинской экологии, ФГБОУ ВО «Северный государственный медицинский университет»</p><p>163000, г. Архангельск, наб. Северной Двины, 17; 163020, г. Архангельск, просп. Никольский, 20; 163069, г. Архангельск, просп. Троицкий, 51</p><p> </p></bio><bio xml:lang="en"><p>Irina S. Kozhevnikova – Cand. Sc. (Biol.), Associate Professor at the Department of Human Biology and Biotechnical Systems, Northern (Arctic) Federal University named after M.V. Lomonosov; Senior Research Officer, Head of the Laboratory of Innovative Technologies, N. Laverov Federal Center for Integrated Arctic Research, Ural Branch of the Russian Academy of Sciences; Associate Professor at the Department of Hygiene and Medical Ecology, Northern State Medical University </p><p>Severnoy Dviny embankment 17, Arkhangelsk 163000; Nikolsky Ave. 20, Arkhangelsk 163020; Troitsky Ave. 51, Arkhangelsk 163069</p><p> </p><p> </p></bio><email xlink:type="simple">i.s.kozhevnikova@narfu.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6609-3292</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фаркова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Farkova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фаркова Анна Андреевна – ассистент кафедры биологии человека и биотехнических систем </p><p>163000, г. Архангельск, наб. Северной Двины, 17</p></bio><bio xml:lang="en"><p>Anna A. Farkova – Teaching Assistant at the Department of Human Biology and Biotechnical Systems</p><p>Severnoy Dviny embankment 17, Arkhangelsk 163000</p></bio><email xlink:type="simple">a.farkova@narfu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8115-0291</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аникина</surname><given-names>Н. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Anikina</surname><given-names>N. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аникина Наталья Юрьевна – кандидат биологических наук, доцент кафедры медицинской и биологической физики</p><p>163069, г. Архангельск, просп. Троицкий, 51</p></bio><bio xml:lang="en"><p>Natalya Yu. Anikina – Cand. Sc. (Biol.), Associate Professor at the Department of Medical and Biological Physics</p><p>Troitsky Ave. 51, Arkhangelsk 163069</p></bio><email xlink:type="simple">anikinanatalja@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-7480-1924</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юрьева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yurieva</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юрьева Елизавета Владимировна – студентка кафедры биологии человека и биотехнических систем</p><p>163000, г. Архангельск, наб. Северной Двины, 17</p></bio><bio xml:lang="en"><p>Elizaveta V. Yuryeva – Student at the Department of Human Biology and Biotechnical Systems</p><p>Severnoy Dviny embankment 17, Arkhangelsk 163000</p></bio><email xlink:type="simple">yureva.e.v@edu.narfu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-6321-3668</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Амелина</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Amelina</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="en"><p>Arina I. Amelina – Student at the Department of Human Biology and Biotechnical Systems</p><p>Severnoy Dviny embankment 17, Arkhangelsk 163000</p></bio><email xlink:type="simple">amelina.a.i@edu.narfu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Северный (Арктический) федеральный университет имени М.В. Ломоносова»</institution></aff><aff xml:lang="en"><institution>Northern (Arctic) Federal University named after M.V. Lomonosov</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «Северный (Арктический) федеральный университет имени М.В. Ломоносова»; &#13;
ФГБУН «Федеральный исследовательский центр комплексного изучения Арктики имени академика Н.П. Лаверова УрО РАН»; &#13;
ФГБОУ ВО «Северный государственный медицинский университет» Минздрава России</institution></aff><aff xml:lang="en"><institution>Northern (Arctic) Federal University named after M.V. Lomonosov; &#13;
Laverov Federal Center for Integrated Arctic Research, Ural Branch of the Russian Academy of Sciences; &#13;
Northern State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБОУ ВО «Северный государственный медицинский университет» Минздрава России</institution></aff><aff xml:lang="en"><institution>Northern State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>26</day><month>09</month><year>2024</year></pub-date><volume>9</volume><issue>4</issue><fpage>35</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кирьянов А.Б., Кожевникова И.С., Фаркова А.А., Аникина Н.Ю., Юрьева Е.В., Амелина А.И., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Кирьянов А.Б., Кожевникова И.С., Фаркова А.А., Аникина Н.Ю., Юрьева Е.В., Амелина А.И.</copyright-holder><copyright-holder xml:lang="en">Kiryanov A.B., Kozhevnikova I.S., Farkova A.A., Anikina N.Y., Yurieva E.V., Amelina A.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/4943">https://www.actabiomedica.ru/jour/article/view/4943</self-uri><abstract><p>Большинство тестов оценивают физиологию в состоянии покоя, тогда как многие симптомы возникают при физической нагрузке, а физическая активность является неотъемлемой частью здорового функционирования и качества жизни человека. На сегодняшний день кардиореспираторное нагрузочное тестирование считается стандартом для выявления ограничений физических нагрузок и дифференциации их причин.</p><p>Кардиореспираторные нагрузочные тесты широко используются как в фундаментальных, так и в новейших исследованиях – от кардиологии и пульмонологии до неврологии и гематологии – и имеют большую прогностическую ценность. Кардиореспираторное нагрузочное тестирование рассматривается как золотой стандарт неинвазивной оценки состояния сердечно-лёгочной системы и физической работоспособности. Ещё большую актуальность и востребованность данное исследование приобрело в связи со вспышкой коронавирусной инфекции COVID-19; сейчас оно играет важную роль в клинической оценке выздоравливающих пациентов, перенёсших COVID-19.</p><p>Многочисленные показатели, зафиксированные на каждом этапе проведения исследования, всовокупности позволяют получить полную картину работы сердечно-сосудистой, дыхательной и мышечной систем, а также изучить особенности метаболического ответа организма в ответ на нагрузку.</p><p>Данная статья содержит обзор литературы по истории применения и развития метода кардиореспираторного нагрузочного тестирования, его физиологическую характеристику и исследование литературы в области применения кардиореспираторного нагрузочного тестирования в медицине за последние 5 лет. Поиск и анализ статей проводились с использованием наукометрических баз данных PubMed, Science Direct, Google Academia. Представленная статья может быть полезна для молодых специалистов в области функциональной диагностики, кардиологии и пульмонологии, а также для научных работников и аспирантов, деятельность которых связана с применением метода кардиореспираторного нагрузочного тестирования.</p></abstract><trans-abstract xml:lang="en"><p>Most tests assess physiology at rest, whereas many symptoms occur with physical exertion, and physical activity is an integral part of healthy functioning and quality of life of a person. Today, cardiopulmonary exercise testing is considered the standard for identifying exercise limitations and differentiating their causes.</p><p>Cardiopulmonary exercise testing is widely used in both basic and the latest research from cardiology and pulmonology to neurology and hematology and has great prognostic value. Cardiopulmonary exercise testing is considered the gold standard for non-invasive assessment of the cardiopulmonary system and physical performance. This study has become even more relevant and in demand due to the COVID-19 outbreak; now it plays an important role in the clinical assessment of recovering patients who have had COVID-19.</p><p>Numerous indicators recorded at each stage of the study, taken together, allow us to obtain a complete picture of the work of the cardiovascular, respiratory and muscular systems, as well as to study the characteristics of the metabolic response to stress.</p><p>This article contains a review of the literature on the history of the application and development of the cardiopulmonary exercise testing, its physiological characteristics and a study of the literature concerning application of studied method in medicine over the past 5 years. The search and analysis of articles were carried out using the scientometric databases PubMed, ScienceDirect, Google Academia.</p><p>The presented article may be useful for young specialists working in functional diagnostics, cardiology and pulmonology, as well as for researchers and postgraduates whose work involves application of the cardiopulmonary exercise testing method.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>кардиореспираторное нагрузочное тестирование</kwd><kwd>КРНТ</kwd><kwd>COVID-19</kwd><kwd>сердечная недостаточность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiopulmonary exercise testing</kwd><kwd>CPET</kwd><kwd>COVID-19</kwd><kwd>heart failure</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Derek T. Cardiopulmonary exercise testing. 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