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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2024-9.4.4</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-4942</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКУШЕРСТВО И ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OBSTETRICS AND GYNAECOLOGY</subject></subj-group></article-categories><title-group><article-title>Факторы, ассоциированные с миомой матки у женщин репродуктивного возраста: кросс-секционное исследование</article-title><trans-title-group xml:lang="en"><trans-title>Factors associated with uterine fibroids in women of reproductive age: A cross-sectional study</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7604-6246</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бабаева</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Babaeva</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бабаева Наталия Игоревна – младший научный сотрудник лаборатории гинекологической эндокринологии</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Natalia I. Babaeva – Junior Research Officer at the Laboratory of Gynecological Endocrinology</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">miracle_909@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5747-7315</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Наделяева</surname><given-names>Я. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Nadeliaeva</surname><given-names>Ia. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наделяева Яна Геннадьевна – кандидат медицинских наук, научный сотрудник лаборатории гинекологической эндокринологии</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Iana G. Nadeliaeva – Cand. Sc. (Med.), Research Officer at the Laboratory of Gynecological Endocrinology</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">janadoc@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8862-5771</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Данусевич</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Danusevich</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Данусевич Ирина Николаевна – доктор медицинских наук, заведующая лабораторией гинекологической эндокринологии</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Irina N. Danusevich – Dr. Sc. (Med.), Leading Research Officer at the Laboratory of Gynecological Endocrinology</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">danusevich@sbamsr.irk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7662-8529</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лазарева</surname><given-names>Л. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Lazareva</surname><given-names>L. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лазарева Людмила Михайловна – кандидат медицинских наук, научный сотрудник лаборатории гинекологической эндокринологии</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Lyudmila M. Lazareva – Cand. Sc. (Med.), Research Offi  at the Laboratory of Gynecological Endocrinology</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">lirken_@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6847-9810</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Егорова</surname><given-names>И. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Egorova</surname><given-names>I. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Егорова Ирина Юрьевна – аспирант, лаборант-исследователь лаборатории гинекологической эндокринологии</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Irina Yu. Egorova – Postgraduate, Laboratory Assistant at the Laboratory of gynecological Endocrinology</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">egorovairina1994@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3407-9365</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аталян</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Atalyan</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Аталян Алина Валерьевна – кандидат биологических наук, старший научный сотрудник лаборатории социально значимых проблем репродуктологии</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Alina V. Atalyan – Cand. Sc. (Biol.), Senior Research Officer at the Laboratory of Socially Significant Problems of Reproductology</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">alinaa@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6271-7803</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сутурина</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Suturina</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сутурина Лариса Викторовна – доктор медицинских наук, профессор, главный научный сотрудник, руководитель отдела охраны репродуктивного здоровья</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Larisa V. Suturina – Dr. Sc. (Med.), Professor, Chief Research Officer, Head of the Department of Reproductive Health</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">lsuturina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»</institution></aff><aff xml:lang="en"><institution>Scientific Centre for Family Health and Human Reproduction Problems</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>26</day><month>09</month><year>2024</year></pub-date><volume>9</volume><issue>4</issue><fpage>26</fpage><lpage>34</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бабаева Н.И., Наделяева Я.Г., Данусевич И.Н., Лазарева Л.М., Егорова И.Ю., Аталян А.В., Сутурина Л.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Бабаева Н.И., Наделяева Я.Г., Данусевич И.Н., Лазарева Л.М., Егорова И.Ю., Аталян А.В., Сутурина Л.В.</copyright-holder><copyright-holder xml:lang="en">Babaeva N.I., Nadeliaeva I.G., Danusevich I.N., Lazareva L.M., Egorova I.Y., Atalyan A.V., Suturina L.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/4942">https://www.actabiomedica.ru/jour/article/view/4942</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Миома матки – доброкачественная моноклональная опухоль, происходящая из гладкомышечного слоя матки. Достаточно широко изучены немодифицируемые факторы риска развития миомы матки, такие как возраст, этническая принадлежность, возраст менархе и другие, в то время как роль многих управляемых факторов остаётся дискутабельной.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Выявить основные модифицируемые факторы, ассоциированные с миомой матки, у женщин репродуктивного возраста в Прибайкалье, в том числе и в отдельных этнических группах.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Нами было проведено мультицентровое кросссекционное исследование в период с 2016 по 2019 г. на базе учреждений г. Иркутск, п. Бохан (Иркутская область) и г. Улан-Удэ (Республика Бурятия). Объектами исследования были женщины, подлежащие ежегодному профилактическому осмотру по месту работы. В исследование вошли 1347 участниц репродуктивного возраста (34,33 ± 6,37 года), соответствующих критериям включения. Среди всех женщин, вошедших в исследование, было 867 (64,37 %) европеоидов, 361 (26,80 %) азиатка и 119 (8,83 %) женщин смешанной, европеоидно-азиатской, этнической принадлежности. Методы исследования включали анкетный опрос, общеклиническое и гинекологическое исследование, а также ультразвуковое исследование органов малого таза.</p></sec><sec><title>Результаты</title><p>Результаты. Основными немодифицируемыми факторами, связанными с наличием миомы матки, по данным нашего исследования, являлись: азиатская этническая принадлежность; возраст менархе 12–13 лет; возраст участницы исследования 40–44 года; наличие менопаузальных симптомов; наличие аденомиоза. Среди «управляемых» факторов установлены: проживание в городе; индекс массы тела более 40 кг/м2; аборты и выкидыши в анамнезе; метаболический синдром; приём комбинированных оральных контрацептивов; отсутствие сексуальной активности; курение; наличие ряда профессиональных вредностей.</p></sec><sec><title>Заключение</title><p>Заключение. В результате нашего исследования были установлены основные управляемые факторы, ассоциированные с наличием миомы матки, в мультиэтнической популяции женщин репродуктивного возраста.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Uterine fibroids is a benign monoclonal tumor originating from the smooth muscle layer of the uterus. Non-modifiable risk factors for the development of uterine fibroids, such as age, ethnicity, age at menarche, etc, have been studied quite extensively, while the role of many controllable factors remains debatable.</p></sec><sec><title>The aim of the study</title><p>The aim of the study. To identify the main modifiable factors associated with uterine fibroids in women of reproductive age living in the Baikal region, including certain ethnic groups.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. We carried out a multicenter cross-sectional study in 2016–2019 in institutions of Irkutsk and Bokhan (Irkutsk region) and Ulan-Ude (Republic of Buryatia). The subjects of the study were women to have annual workplace medical examination. The study included 1,347 participants of reproductive age (34.33 ± 6.37 years) who met the inclusion criteria. Among all women included in the study, there were 867 (64.37 %) Caucasians, 361 (26.80 %) Asians, and 119 (8.83%) women of mixed (Caucasian-Asian), ethnicity. The research methods included a questionnaire, general clinical and gynecological examination, and pelvic ultrasound examination.</p></sec><sec><title>Results</title><p>Results. According to our study, the main non-modifiable factors associated with the presence of uterine fibroids were: Asian ethnicity; age at menarche 12–13 years; age of the study participant 40–44 years; menopausal symptoms; adenomyosis. The “controllable” factors included: city residency; body mass index over 40 kg/m2; history of abortions and miscarriages; metabolic syndrome; using combined oral contraceptives; lack of sexual activity; smoking; presence of anumber of occupational hazards.</p></sec><sec><title>Conclusion</title><p>Conclusion. Our study identified the main controllable factors associated with the presence of uterine fibroids in a multiethnic population of women of reproductive age.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>миома матки</kwd><kwd>управляемые факторы</kwd><kwd>этническая принадлежность</kwd><kwd>репродуктивный возраст</kwd></kwd-group><kwd-group xml:lang="en"><kwd>uterine fibroids</kwd><kwd>controllable factors</kwd><kwd>ethnicity</kwd><kwd>reproductive age</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование проведено за счёт государственной бюджетной темы № 121022500180-6 «Патофизиологические механизмы и генетико-метаболические предикторы сохранения репродуктивного здоровья и долголетия в различных возрастных, гендерных и этнических группах».</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гаспаров А.С., Дорфман М.Ф., Дубинская Е.Д., Вартанян С.Л., Губанова Е.В., Дорфман С.Ф. 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