actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.29413/ABS.2024-9.3.5actabiomedica-4815Research ArticleАКУШЕРСТВО И ГИНЕКОЛОГИЯOBSTETRICS AND GYNAECOLOGYУльтрасонографические нормативы структуры яичников у женщин репродуктивного возраста различной этнической принадлежностиUltrasonographic threshold of ovarian structure in premenopausal women of different ethnicityhttps://orcid.org/0000-0002-7662-8529ЛазареваЛ. М.LazarevaL. M.

Лазарева Людмила Михайловна – кандидат медицинских наук, научный сотрудник лаборатории гинекологической эндокринологии

664003, г. Иркутск, ул. Тимирязева, 16

Lyudmila M. Lazareva – Cand. Sc. (Med.), Research Officer at the Laboratory of Gynecological Endocrinology

Timiryazeva str. 16, Irkutsk 664003

lirken_@mail.ruhttps://orcid.org/0000-0002-3407-9365АталянА. В.AtalyanA. V.

Аталян Алина Валерьевна – кандидат биологических наук, старший научный сотрудник лаборатории социально-значимых проблем репродуктологии

664003, г. Иркутск, ул. Тимирязева, 16

Alina V. Atalyan – Cand. Sc. (Biol.), Senior Research Officer at the Laboratory of Socially Significant Problems of Reproduction

Timiryazeva str. 16, Irkutsk 664003

alinaa@mail.ruhttps://orcid.org/0000-0002-8862-5771ДанусевичИ. Н.DanusevichI. N.

Данусевич Ирина Николаевна – доктор медицинских наук, главный научный сотрудник лаборатории гинекологической эндокринологии

664003, г. Иркутск, ул. Тимирязева, 16

Irina N. Danusevich – Dr. Sc. (Med.), Chief Research Officer at the Laboratory of Gynecological Endocrinology

Timiryazeva str. 16, Irkutsk 664003

irinaemails@gmail.ruhttps://orcid.org/0000-0002-5747-7315НаделяеваЯ. Г.NadeliaevaI. G.

Наделяева Яна Геннадьевна – кандидат медицинских наук, научный сотрудник лаборатории гинекологической эндокринологии

664003, г. Иркутск, ул. Тимирязева, 16

Iana G. Nadeliaeva – Cand. Sc. (Med.), Research Officer at the Laboratory of Gynecological Endocrinology

Timiryazeva str. 16, Irkutsk 664003

ianadoc@mail.ruhttps://orcid.org/0000-0003-4904-3709БеленькаяЛ. В.BelenkayaL. V.

Беленькая Лилия Васильевна – кандидат медицинских наук, старший научный сотрудник лаборатории физиологии и патологии эндокринной системы

664003, г. Иркутск, ул. Тимирязева, 16

Lilia V. Belenkaya – Cand. Sc. (Med.), Senior Research Officer at the Laboratory of Physiology and Pathology of the Endocrine System

Timiryazeva str. 16, Irkutsk 664003

Drblv@mail.ruhttps://orcid.org/0000-0001-6847-9810ЕгороваИ. Ю.EgorovaI. Yu.

Егорова Ирина Юрьевна – аспирант лаборатории гинекологической эндокринологии

664003, г. Иркутск, ул. Тимирязева, 16

Irina Yu. Egorova – Postgraduate at the Laboratory of Gynecological Endocrinology

Timiryazeva str. 16, Irkutsk 664003

egorovairina1994@gmail.comhttps://orcid.org/0000-0002-7604-6246БабаеваН. И.BabaevaN. I.

Бабаева Наталия Игоревна – младший научный сотрудник лаборатории гинекологической эндокринологии

664003, г. Иркутск, ул. Тимирязева, 16

Natalia I. Babaeva – Junior Research Officer at the Laboratory of Gynecological Endocrinology

Timiryazeva str. 16, Irkutsk 664003

miracle_909@mail.ruhttps://orcid.org/0000-0002-6271-7803СутуринаЛ. В.SuturinaL. V.

Сутурина Лариса Викторовна – доктор медицинских наук, профессор, главный научный сотрудник лаборатории гинекологической эндокринологии

664003, г. Иркутск, ул. Тимирязева, 16

Larisa V. Suturina – Dr. Sc. (Med.), Professor, Chief Research Officer at the Laboratory of Gynecological Endocrinology

Timiryazeva str. 16, Irkutsk 664003

lsuturina@mail.ruФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»Scientific Сentre for Family Health and Human Reproduction Problems202422072024934968Copyright © Лазарева Л.М., Аталян А.В., Данусевич И.Н., Наделяева Я.Г., Беленькая Л.В., Егорова И.Ю., Бабаева Н.И., Сутурина Л.В., 20242024Лазарева Л.М., Аталян А.В., Данусевич И.Н., Наделяева Я.Г., Беленькая Л.В., Егорова И.Ю., Бабаева Н.И., Сутурина Л.В.Lazareva L.M., Atalyan A.V., Danusevich I.N., Nadeliaeva I.G., Belenkaya L.V., Egorova I.Y., Babaeva N.I., Suturina L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/4815

Поликистозная структура яичников (ПКЯ) является общепризнанным ультразвуковым маркером овуляторной дисфункции, служит одним из критериев синдрома поликистозных яичников (СПКЯ) и устанавливается на основании оценки объёма яичников (ОЯ) и количества фолликулов на яичник (КФЯ) с учётом верхних нормальных значений, определяемых в здоровых популяциях женщин репродуктивного возраста. Однако отмечается необходимость регулярного пересмотра характеристик ПКЯ в зависимости от этнических и возрастных особенностей.Цель. Разработать дифференцированные нормативы для оценки ультрасонографической структуры яичников у женщин репродуктивного возраста различной этнической принадлежности.Материалы и методы. В период с марта 2016 по декабрь 2019 г. проведено многоцентровое поперечное (кросс-секционное) проспективное исследование на территории Восточной Сибири (Иркутская область) и в сопредельной Республике Бурятия. В исследование вошли 1134 участницы: 715 женщин европеоидной принадлежности, 312 – азиатской, 107 – смешанной этнической субпопуляции.Результаты. Установлено, что для европеоидов ПКЯ целесообразно диагностировать при объёме яичников 9 см3 и/или КФЯ ≥ 12; для женщин азиатской популяции – при объёме яичников 7 см3 и/или КФЯ ≥ 11; для женщин смешанной этнической принадлежности – при объёме 8 см3 и/или КФЯ ≥ 9. Важным преимуществом нашего исследования является то, что все участницы были рекрутированы в неселективной мультиэтнической популяции женщин с сопоставимыми социально-демографическими характеристиками, проживающих в одинаковых географических условиях.Выводы. Для дифференцированного подхода к выявлению поликистозной структуры яичников у женщин репродуктивного возраста различных этнических групп необходимо принимать этнически дифференцированные нормативные значения.

The polycystic ovarian morphology (PCOM) is a generally accepted ultrasound marker for ovulatory dysfunction, is one of the criteria for polycystic ovary syndrome (PCOS) and is established based on the assessment of ovarian volume (OV) and the follicle number per ovary (FNPO), taking into account the upper normal values determined in healthy premenopausal women. However, there is a necessity for regular revision of the PCOM characteristics depending on ethnic and age characteristics.The aim. To develop differentiated standards for assessing the ultrasonographic ovary structure in premenopausal women of various ethnicity.Materials and methods. From March 2016 to December 2019, a multicenter cross-sectional prospective study was conducted in Eastern Siberia (Irkutsk region) and in the neighboring Republic of Buryatia. The study included 1134 participants: 715 women of Caucasian origin, 312 Asian women, 107 women of mixed ethnic subpopulation.Results. It has been established that for Caucasians, it is advisable to diagnose PCOM when the ovarian volume is 9 cm3 and/or FNPO ≥ 12; for women of the Asian population – when the ovarian volume is 7 cm3 and/or FNPO ≥ 11; for women of mixed ethnicity – when the ovarian volume is 8 cm3 and/or FNPO ≥ 9. An important advantage of our study is that all participants were recruited from a non-selective multi-ethnic population of women with comparable socio-demographic characteristics living in the same geographical conditions.Conclusion. Differentiated approach for identifying the polycystic ovarian morphology in premenopausal women of different ethnic groups requires using ethnically differentiated normative readings

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The authors declare that there are no conflicts of interest present.