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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2024-9.2.16</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-4738</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОФТАЛЬМОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPHTHALMOLOGY</subject></subj-group></article-categories><title-group><article-title>Возможности применения нейросетевого анализа в диагностике синдрома «сухого глаза»</article-title><trans-title-group xml:lang="en"><trans-title>Possibilities of using neural network analysis in the diagnosis of dry eye syndrome</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6223-8888</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Таскина</surname><given-names>Е. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Taskina</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Таскина Елизавета Сергеевна – кандидат медицинских наук, доцент кафедры офтальмологии.</p><p>672000, Чита, ул. Горького, 39а</p></bio><bio xml:lang="en"><p>ElizaVeta S. Taskina – Cand. Sc. (Med.), Associate Professor at the Department of Ophthalmology.</p><p>Gorkiy str., 39a, Chita, 672000</p></bio><email xlink:type="simple">taskins@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-3919-2479</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьёва</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Solovyova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соловьёва Алина Андреевна – студентка 6-го курса.</p><p>672000, Чита, ул. Горького, 39а</p></bio><bio xml:lang="en"><p>Alina A. Solovyova – Sixth-Year Student.</p><p>Gorkiy str., 39a, Chita, 672000</p></bio><email xlink:type="simple">candywhj@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5961-5400</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мудров</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mudrov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мудров Виктор Андреевич – доктор медицинских наук, доцент кафедры акушерства и гинекологии лечебного и стоматологического факультетов.</p><p>672000, Чита, ул. Горького, 39а</p></bio><bio xml:lang="en"><p>Victor A. MudroV – Dr. Sc. (Med.), Associate Professor at the Department of Obstetrics and Gynecology of the Faculties of Medicine and Dentistry.</p><p>Gorkiy str., 39a, Chita, 672000</p></bio><email xlink:type="simple">mudrov_viktor@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8899-5465</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Харинцева</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kharintseva</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Харинцева Светлана Владимировна – доктор медицинских наук, профессор, заведующая кафедрой офтальмологии.</p><p>672000, Чита, ул. Горького, 39а</p></bio><bio xml:lang="en"><p>Svetlana V. Kharinseva – Dr. Sc. (Med.), Professor, Head of the Department of Ophthalmology.</p><p>Gorkiy str., 39a, Chita, 672000</p></bio><email xlink:type="simple">s.v.19.28@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Читинская государственная медицинская академия» Минздрава России</institution></aff><aff xml:lang="en"><institution>Chita State Medical Academy</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>01</day><month>06</month><year>2024</year></pub-date><volume>9</volume><issue>2</issue><fpage>161</fpage><lpage>171</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Таскина Е.С., Соловьёва А.А., Мудров В.А., Харинцева С.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Таскина Е.С., Соловьёва А.А., Мудров В.А., Харинцева С.В.</copyright-holder><copyright-holder xml:lang="en">Taskina E.S., Solovyova A.A., Mudrov V.A., Kharintseva S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/4738">https://www.actabiomedica.ru/jour/article/view/4738</self-uri><abstract><p>Распространённость синдрома «сухого глаза» варьирует от 6,5 до 95 %. Диагностические критерии основываются на разных методах и/или их сочетаниях и характеризуются неоднородностью.</p><sec><title>Цель исследования</title><p>Цель исследования. Выявление факторов риска развития синдрома «сухого глаза» для создания технологии ранней диагностики степени данного заболевания у лиц молодого возраста без сопутствующей глазной и общей соматической патологии.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Обследовано 50 пациентов в возрасте 24 [22; 27] лет. Проведено офтальмологическое обследование, включающее авторефрактометрию, визометрию, биомикроскопию, проведение пробы Норна, анкетирование по авторскому опроснику и оценку степени синдрома «сухого глаза» по тесту Оcular Surface Disease Index (OSDI). Сформировано три группы исследования: группа контроля (OSDI = 0–13 баллов); первая группа – пациенты, имеющие OSDI = 14–22 балла; вторая группа – пациенты, имеющие OSDI &gt; 22 баллов.</p></sec><sec><title>Результаты</title><p>Результаты. При изучении представленных независимых переменных наибольшую нормализованную важность имеет значение экранного времени (100 %), далее следуют время разрыва слёзной плёнки (58,4 %), курение (24,3 %), ночные смены (22,5 %) и ношение мягких контактных линз (11,1 %). Технология ранней диагностики степени синдрома «сухого глаза» реализована на базе многослойного персептрона, процент неверных предсказаний в процессе обучения которого составил 8,0 %. Структура обучаемой нейронной сети включала 8 входных нейронов (значение экранного времени и времени разрыва слёзной плёнки, наличие или отсутствие факта курения, ночные смены и/ или использование мягких контактных линз), два скрытых слоя, содержащих 3 и 2 единицы соответственно, и 3 выходных нейрона.</p></sec><sec><title>Заключение</title><p>Заключение. Предложенная нейросеть не испытывает затруднений в оценке ранней диагностики тяжести синдрома «сухого глаза» и может быть использована в клинической практике.</p></sec></abstract><trans-abstract xml:lang="en"><p>The prevalence rate of dry eye syndrome varies from 6.5 to 95 %. Diagnostic criteria are based on different methods and/or their combinations and are characterized by heterogeneity.</p><sec><title>The aim of the study</title><p>The aim of the study. To identify the risk factors for the development of dry eye syndrome in order to create a technology for early diagnosis of the degree of the disease in young people without concomitant ocular and general somatic pathology.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Fifty patients aged 24 [22; 27] years were examined. We carried out an ophthalmological examination, including autorefractometry, visometry, biomicroscopy, the Norn test, a survey using the author’s questionnaire, and an assessment of the degree of dry eye syndrome using the Ocular Surface Disease Index (OSDI). Three study groups were formed: control group (OSDI = 0–13 points); group 1 – patients with OSDI = 14–22 points; group 2 – patients with OSDI &gt; 22 points.</p></sec><sec><title>Results</title><p>Results. When examining presented independent variables, screen time had the highest normalized importance (100 %), followed by tear film breakup time (58.4 %), smoking (24.3 %), night shifts (22.5 %) and using soft contact lenses (11.1 %). The technology for early diagnosis of the degree of dry eye syndrome is implemented on the basis of a multilayer perceptron, the percentage of incorrect predictions during its training process was 8.0 %. The structure of the trained neural network included 8 input neurons (the value of screen time and tear film breakup time, the presence or absence of smoking, night shifts and/or the use of soft contact lenses), two hidden layers containing 3 and 2 units, respectively, and 3 output neurons.</p></sec><sec><title>Conclusion</title><p>Conclusion. The proposed neural network has no difficulties in assessing the early diagnosis of the severity of dry eye syndrome and can be used in clinical practice.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром «сухого глаза»</kwd><kwd>время разрыва слёзной плёнки</kwd><kwd>экранное время</kwd><kwd>OSDI</kwd><kwd>факторы риска</kwd><kwd>технология диагностики</kwd><kwd>нейросетевой анализ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dry eye syndrome</kwd><kwd>tear film breakup time</kwd><kwd>screen time</kwd><kwd>OSDI</kwd><kwd>risk factors</kwd><kwd>diagnostic technology</kwd><kwd>neural network analysis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Jones L, Downie LE, Korb D, Benitez-Del-Castillo JM, Dana R, Deng SX, et al. TFOS DEWS II management and therapy report. 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