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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2024-9.2.10</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-4732</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURES</subject></subj-group></article-categories><title-group><article-title>Профилактика периоперационного ишемического инсульта после некардиохирургических и ненейрохирургических операций в свете Научного заявления и Рекомендаций по вторичной профилактике ишемического инсульта и транзиторной ишемической атаки AHA/ASA. Часть 2: периоперационная антитромботическая терапия, диагностика, лечение</article-title><trans-title-group xml:lang="en"><trans-title>Prevention of perioperative ischemic stroke after non-cardiac and non-neurosurgical operations in the light of the Scientific Statement and Guidelines for the Secondary Prevention of Ischemic Stroke and Transient Ischemic Attack AHA/ASA 2021. Part 2: Perioperative antithrombotic therapy, diagnosis, treatment</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6484-286X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Янишевский</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Yanishevskiy</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Янишевский Станислав Николаевич – доктор медицинских наук, заведующий научно-исследовательской лабораторией неврологии и нейрореабилитации, главный научный сотрудник научно-исследовательской лаборатории технологий прогнозирования риска развития сердечно-сосудистых осложнений, профессор кафедры неврологии.</p><p>197341, Санкт-Петербург, ул. Аккуратова, 2</p></bio><bio xml:lang="en"><p>Stanislav N. Yanishevskiy – Dr. Sc. (Med.), Head of the Research Laboratory for Neurology and Neurorehabilitation, Chief Research Officer at the Research Laboratory of Technologies for Predicting the Risk of Developing Cardiovascular Complications, Almazov NMRC.</p><p>Akkuratova str. 2, Saint Petersburg 197341</p></bio><email xlink:type="simple">yanishevskiy_sn@almazovcentre.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3756-6214</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коломенцев</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolomencev</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коломенцев Сергей Витальевич – кандидат медицинских наук, начальник неврологического отделения кафедры и клиники нервных болезней имени М.И. Аствацатурова, ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» МРФ; старший научный сотрудник Балтийского центра нейротехнологий и искусственного интеллекта, ФГАОУ ВО «Балтийский ФУ имени Иммануила Канта».</p><p>194044, Санкт-Петербург, ул. Академика Лебедева, 6; 236041, Калининград, ул. Александра Невского, 14</p></bio><bio xml:lang="en"><p>Sergey V. Kolomencev – Cand. Sc. (Med.), Head of the Neurology Department, M.I. Astvatsaturov Department and Clinic of Nervous Diseases, Kirov MMA; Senior Research Officer at the Baltic Centre for Neurotechnologies and Artificial Intelligence, Immanuel Kant Baltic FU.</p><p>Akademika Lebedeva str. 6, Saint Petersburg 194044; Aleksandra Nevskogo str. 14, Kaliningrad 236041</p></bio><email xlink:type="simple">skolomencev@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0340-4110</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вознюк</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Voznjouk</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вознюк Игорь Алексеевич – доктор медицинских наук, профессор, заместитель главного врача по неврологии, ФГБОУ ВО «Первый Санкт-Петербургский ГМУ имени академика И.П. Павлова» Минздрава России; профессор кафедры психиатрии и нейронаук, ФГАОУ ВО «Балтийский ФУ имени Иммануила Канта».</p><p>236041, Калининград, ул. Александра Невского, 14; 197022, Санкт-Петербург, ул. Льва Толстого, 6-8</p></bio><bio xml:lang="en"><p>Igor A. Voznjouk – Dr. Sc. (Med.), Professor, Deputy Chief Physician for Neurology, Pavlov First Saint Petersburg SMU; Professor at the Department of Psychiatry and Neuroscience, Immanuel Kant Baltic FU.</p><p>Aleksandra Nevskogo str. 14, Kaliningrad 236041; Lva Tolstogo str. 6-8, Saint Petersburg 197022</p></bio><email xlink:type="simple">voznjouk@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1680-6119</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Савелло</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Savello</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Савелло Александр Викторович – доктор медицинских наук, профессор, заместитель начальника кафедры и клиники нейрохирургии, ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» Министерства обороны Российской Федерации; профессор кафедры нейрохирургии, ФГБОУ ВО «Первый Санкт-Петербургский ГМУ имени академика И.П. Павлова» Минздрава России.</p><p>194044, Санкт-Петербург, ул. Академика Лебедева, 6; 197022, Санкт-Петербург, ул. Льва Толстого, 6-8</p></bio><bio xml:lang="en"><p>Alexander V. Savello – Dr. Sc. (Med.), Professor, Deputy Head of the M.I. Astvatsaturov Department and Clinic of Nervous Diseases, Kirov MMA; Professor at the Department of Neurosurgery, Pavlov First Saint Petersburg SMU.</p><p>Akademika Lebedeva str. 6, Saint Petersburg 194044; Lva Tolstogo str. 6-8, Saint Petersburg 197022</p></bio><email xlink:type="simple">alexander.savello@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4163-1701</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шерматюк</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Shermatyuk</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шерматюк Евгений Игоревич – старший ординатор неврологического отделения кафедры и клиники нервных болезней имени М.И. Аствацатурова.</p><p>194044, Санкт-Петербург, ул. Академика Лебедева, 6</p></bio><bio xml:lang="en"><p>EVGeny I. Shermatyuk – Senior Clinical Resident at the Neurology Department, M.I. Astvatsaturov Department and Clinic of Nervous Diseases.</p><p>Akademika Lebedeva str. 6, Saint Petersburg 194044</p></bio><email xlink:type="simple">sherma1@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8988-3011</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Литвиненко</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Litvinenko</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Литвиненко Игорь Вячеславович – доктор медицинских наук, профессор, начальник кафедры и клиники нервных болезней имени М.И. Аствацатурова.</p><p>194044, Санкт-Петербург, ул. Академика Лебедева, 6</p></bio><bio xml:lang="en"><p>Igor V. Litvinenko – Dr. Sc. (Med.), Professor, Head of the M.I. Astvatsaturov Department and Clinic of Nervous Diseases.</p><p>Akademika Lebedeva str. 6, Saint Petersburg 194044</p></bio><email xlink:type="simple">litvinenkoiv@rambler.ru</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Национальный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России</institution></aff><aff xml:lang="en"><institution>Almazov National Medical Research Centre</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» Министерства обороны Российской Федерации; ФГАОУ ВО «Балтийский федеральный университет имени Иммануила Канта»</institution></aff><aff xml:lang="en"><institution>Kirov Military Medical Academy; Immanuel Kant Baltic Federal University</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО «Балтийский федеральный университет имени Иммануила Канта»; ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Минздрава России</institution></aff><aff xml:lang="en"><institution>Immanuel Kant Baltic Federal University; Pavlov First Saint Petersburg State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» Министерства обороны Российской Федерации; ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Минздрава России</institution></aff><aff xml:lang="en"><institution>Kirov Military Medical Academy; Pavlov First Saint Petersburg State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru"><institution>ФГБВОУ ВО «Военно-медицинская академия им. С.М. Кирова» Министерства обороны Российской Федерации</institution></aff><aff xml:lang="en"><institution>Kirov Military Medical Academy</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>31</day><month>05</month><year>2024</year></pub-date><volume>9</volume><issue>2</issue><fpage>98</fpage><lpage>111</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Янишевский С.Н., Коломенцев С.В., Вознюк И.А., Савелло А.В., Шерматюк Е.И., Литвиненко И.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Янишевский С.Н., Коломенцев С.В., Вознюк И.А., Савелло А.В., Шерматюк Е.И., Литвиненко И.В.</copyright-holder><copyright-holder xml:lang="en">Yanishevskiy S.N., Kolomencev S.V., Voznjouk I.A., Savello A.V., Shermatyuk E.I., Litvinenko I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/4732">https://www.actabiomedica.ru/jour/article/view/4732</self-uri><abstract><p>Одной из возможных мер, способных улучшить качество оказания медицинской помощи, уменьшить число неблагоприятных исходов, а также достичь целевых значений по применению реперфузионных методов лечения при остром ишемическом инсульте, является совершенствование системы оказания помощи пациентам с внутригоспитальным ишемическим инсультом. Одним из видов внутригоспитального инсульта является периоперационный инсульт – инсульт, развившийся во время или спустя 30 дней после выполнения хирургической операции. С момента опубликования в 2014 г. последней фундаментальной работы на тему профилактики периоперационного инсульта подходы к первичной и вторичной профилактике, диагностике, консервативному и реперфузионному лечению ишемического инсульта были серьёзно модифицированы. Произошедшие многочисленные изменения создали предпосылки к пересмотру существующих подходов к оказанию помощи при периоперационном ишемическом инсульте. В 2021 г. в свет вышли обновлённые документы зарубежных исследователей/ассоциаций, посвящённые проблеме периоперационного ишемического инсульта у пациентов некардиохирургического и ненейрохирургического профиля. Во второй части обзора представлены современные данные, посвящённые вопросам периоперационной антитромботической профилактики, клинической и инструментальной диагностики, лечения и организации оказания помощи при периоперационном ишемическом инсульте у данной категории пациентов. Подробнорассмотрены вопросы применения у пациентов некардиохирургического и ненейрохирургического профиля с периоперационным инсультом реперфузионных методов лечения – системной тромболитической терапии и эндоваскулярных вмешательств, в т. ч. приведён мировой опыт их применения «off-label».</p></abstract><trans-abstract xml:lang="en"><p>One of the possible measures that can enhance the quality of medical care, reduce the number of adverse outcomes, and also achieve target values for the use of reperfusion methods of treatment for acute ischemic stroke is to improve the system of care for patients with in-hospital ischemic stroke. One type of in-hospital stroke is perioperative stroke that develops during or 30 days after surgery. Since the publication in 2014 of the last fundamental work on the prevention of perioperative stroke, the approaches to primary and secondary prevention, diagnosis, conservative and reperfusion treatment of ischemic stroke have been seriously modified. The numerous changes have created the preconditions for a revision of existing approaches to providing care for patients with perioperative ischemic stroke. In 2021, updated documents from foreign researchers/associations on the perioperative ischemic stroke in non-cardiac and non-neurosurgical patients were published. The second part of our review presents current data on the perioperative antithrombotic prophylaxis, clinical and instrumental diagnosis, treatment and organization of care for perioperative ischemic stroke in this category of patients. The issues of using reperfusion treatment methods in non-cardiac and non-neurosurgical patients with perioperative stroke, such as systemic thrombolytic therapy and endovascular interventions, are discussed in detail, including the world experience of their “offlabel” use.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>периоперационный инсульт</kwd><kwd>внутригоспитальный ишемический инсульт</kwd><kwd>некардиохирургическое и ненейрохирургическое оперативное вмешательство</kwd><kwd>антитромботическая профилактика</kwd><kwd>системная тромболитическая терапия</kwd><kwd>эндоваскулярное вмешательство</kwd></kwd-group><kwd-group xml:lang="en"><kwd>perioperative stroke</kwd><kwd>in-hospital ischemic stroke</kwd><kwd>non-cardiac and nonneurosurgical operative treatment</kwd><kwd>antithrombotic prophylaxis</kwd><kwd>systemic thrombolytic therapy</kwd><kwd>endovascular intervention</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Cumbler E, Wald H, Bhatt DL, Cox M, Xian Y, Reeves M, et al. 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