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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2025-10.3.4</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-4690</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВНУТРЕННИЕ БОЛЕЗНИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INTERNAL DISEASES</subject></subj-group></article-categories><title-group><article-title>Эхокардиографические изменения после перенесенной инфекции COVID-19 с поражением легких и их связь с проявлениями постковидного синдрома (проспективное 6-месячнное наблюдение)</article-title><trans-title-group xml:lang="en"><trans-title>Echocardiographic changes after COVID-19 infection with lung damage and their association with  manifestations of post-COVID syndrome (prospective 6-month follow-up)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1843-5312</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Григоричева</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Grigoricheva</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Григоричева Елена Александровна – доктор медицинских наук, профессор кафедры поликлинической терапии и клинической фармакологии </p><p>454096, г. Челябинск, Воровского, 64</p></bio><bio xml:lang="en"><p>Elena A. Grigoricheva – Dr. Sc. (Med.), Professor of the Department of Polyclinic Therapy and Clinical Pharmacology </p><p>Vorovskogo, 64, Chelyabinsk 454096</p></bio><email xlink:type="simple">Lenaqriq@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1122-1901</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гессен</surname><given-names>Г. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Gessen</surname><given-names>G. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гессен Галина Рафаэлевна – врач-терапевт, участковый терапевтического отделения поликлиники </p><p>628260, Тюменская область, ХМАО-Югра, г. Югорск, ул. Попова, д. 29/1</p></bio><bio xml:lang="en"><p>Galina R. Gessen - local therapist of the Therapeutic Department of the polyclinic </p><p>st. Popova, 29/1, Yugorsk, Khanty-Mansiisk Autonomous Okrug-Yugra, Tyumen region, 628260</p></bio><email xlink:type="simple">galgessen@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-9097-6289</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Серова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Serova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Серова Татьяна Валерьевна – студентка </p><p>454096, г. Челябинск, Воровского, 64</p></bio><bio xml:lang="en"><p>Tatyana V. Serova – student </p><p>Vorovskogo, 64, Chelyabinsk 454096</p></bio><email xlink:type="simple">tatyanka.serova.2000@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-1293-8738</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Базаркина</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bazarkina</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Базаркина Любовь Владимировна – студентка </p><p>454096, г. Челябинск, Воровского, 64</p></bio><bio xml:lang="en"><p>Lyubov V. Bazarkina – student </p><p>Vorovskogo, 64, Chelyabinsk 454096</p></bio><email xlink:type="simple">bazarkina_lyuba@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Южно-Уральский государственный медицинский университет» Минздрава России</institution></aff><aff xml:lang="en"><institution>South Ural State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>БУ ХМАО-Югры «Югорская городская больница»</institution></aff><aff xml:lang="en"><institution>Yugorsk city hospital</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>22</day><month>07</month><year>2025</year></pub-date><volume>10</volume><issue>3</issue><fpage>37</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Григоричева Е.А., Гессен Г.Р., Серова Т.В., Базаркина Л.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Григоричева Е.А., Гессен Г.Р., Серова Т.В., Базаркина Л.В.</copyright-holder><copyright-holder xml:lang="en">Grigoricheva E.A., Gessen G.R., Serova T.V., Bazarkina L.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/4690">https://www.actabiomedica.ru/jour/article/view/4690</self-uri><abstract><p>Обоснование. Текущая и перенесенная инфекция COVID-19 может провоцировать и усугублять течение заболеваний сердечно-сосудистой системы, инициируя процессы тромбообразования, воспаления и синтеза фибриногена, поражая плевроперикардиальное пространство, увеличивая нагрузку на правые отделы сердца. Стадийность инфекционного процесса требует проведения проспективных исследований для верификации характера поражения сердца и его связи с клиническими проявлениями и прогнозом в каждой из фаз. Цель. Выявить особенности поражения сердца после перенесенной инфекции COVID-19 с поражением легких у практически здоровых людей, динамику их состояния при 6-месячном проспективном наблюдении, и сопоставить их с клиническими проявлениями постковидного синдрома. Материалы и методы. Проведено закрытое когортное проспективное (6-месячное) клиническое и эхокардиографическое исследование 100 пациентов. Данные эхокардиографического исследования были сопоставлены с клиническими проявлениями постковидного синдрома. Результаты. В первый месяц наблюдения у пациентов после перенесенной инфекции СOVID–19 основными клиническими проявлениями были общая слабость, одышка при физической нагрузке, отеки нижних конечностей, сердцебиение, артериальная гипертензия, торакалгия, на эхокардиографии – дилатация левого предсердия и правого желудочка, увеличение давления в легочной артерии, признаки нарушения релаксации левого желудочка,, клапанные регургитации, наличие жидкости в полости перикарда, с положительной динамикой к 6 месяцу наблюдения. Показатели эхокардиографии достоверно ассоциированы с одышкой, общей слабостью, сердцебиением, повышением артериального давления, отеками на ногах. Заключение. В первый месяц после перенесенной инфекции СOVID–19 в изучаемой группе пациентов на эхокардиографии характерными являются дилатация камер сердца, повышение систолического давления в легочной артерии и клапанные регургитации, нарушение диастолической функции левого желудочка и наличие жидкости в полости перикарда со стабилизацией показателей к шестому месяцу. Получена связь показателей эхокардиографии.</p></abstract><trans-abstract xml:lang="en"><p>Background. Current and past COVID-19 infection can provoke and aggravate the course of cardiovascular diseases, initiating the processes of thrombosis, inflammation and fibrinogen synthesis, affecting the pleuropericardial space, increasing the load on the right heart. The staging of the infectious process requires prospective studies to verify the nature of heart damage and its relationship with clinical manifestations and prognosis in each phase. The aim. To identify the features of heart damage after past COVID-19 infection with lung damage in practically healthy people, their condition dynamics during a 6-month prospective observation, and compare them with the clinical manifestations of post-COVID syndrome. Materials and methods. A closed cohort prospective (6-month) clinical and echocardiographic study of 100 patients was conducted. The echocardiographic study data were compared with the clinical manifestations of post-COVID syndrome. Results. In the first month of observation, the main clinical manifestations in patients after the COVID-19 infection were general weakness, shortness of breath during physical exertion, swelling of the lower extremities, palpitations, arterial hypertension, thoracic pain, dilation of the left atrium and right ventricle on echocardiography, increased pressure in the pulmonary artery, signs of impaired relaxation of the left ventricle, valvular regurgitation, the presence of fluid in the pericardial cavity, with positive dynamics by the 6th month of observation. Echocardiography indicators are reliably associated with shortness of breath, general weakness, palpitations, increased blood pressure, and swelling of the legs. Conclusion. The first month after the COVID-19 infection, in the studied group of patients, echocardiography is characterized by dilation of the heart chambers, increased systolic pressure in the pulmonary artery and valvular regurgitation, impaired diastolic function of the left ventricle and the presence of fluid in the pericardial cavity with stabilization of the indicators by the sixth month. A relationship was found between echocardiography parameters and clinical manifestations.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>эхокардиография</kwd><kwd>постковидный синдром</kwd><kwd>проспективное наблюдение</kwd><kwd>поражение сердца</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>echocardiography</kwd><kwd>post-COVID syndrome</kwd><kwd>prospective observation</kwd><kwd>cardiac involvement</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Временные методические рекомендации: Профилактика, диагностика и лечение новой коронавирусной болезни (COVID-19). Версия 16 от 18.08.2021 г. 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