actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problemsactabiomedica-46Research ArticleОБЗОРЫREVIEWSИспользование нестероидных противовоспалительных препаратов для профилактики острого панкреатита после эндоскопической ретроградной холангиопанкреатографии (обзор литературы)Use of non-steroid anti-inflammatory preparations for prevention of acute pancreatitis after endoscopic retrograde cholangiopancreatography (literature review)МорозЕ. В.MorozE. V.noemail@neicon.ruСоколовА. А.SokolovA. A.noemail@neicon.ruАртемкинЭ. Н.ArtemkinE. N.noemail@neicon.ruФГКУ «Главный военный клинический госпиталь им. акад. Н.Н. Бурденко» Минобороны РФCentral Military Clinical Hospital named after Acad. N.N. BurdenkoГБОУ ВПО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава РФPirogov Russian National Research Medical University20152804201502115121Copyright © Мороз Е.В., Соколов А.А., Артемкин Э.Н., 20152015Мороз Е.В., Соколов А.А., Артемкин Э.Н.Moroz E.V., Sokolov A.A., Artemkin E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/46

Эндоскопическая ретроградная холангиопанкреатография (ЭРХПГ) - один из важнейших методов диагностики заболеваний органов панкреатобилиарной зоны. Помимо визуализации внутрипротоковых изменений, эта методика позволяет осуществлять широкий спектр хирургических вмешательств, таких, как папиллосфинктеротомия,удаление конкрементов,установка стентов и др. К сожалению, при проведении ЭРХПГ могут возникать серьезные осложнения, в первую очередь, острый панкреатит. Для предупреждения развития этой патологии предложены различные технические и фармакологические подходы, однако далеко не все из них доказали свою эффективность в ходе клинических испытаний. Одним из наиболее удачных средств для профилактики ЭРХПГ-ассоциированного панкреатита оказалось применение нестероидных противовоспалительных препаратов (НПВП). Настоящий обзор посвящен анализу литературных данных по данному вопросу.

Non-steroid anti-inflammatory preparations (NSAlDs) - a unique class of the medical products possessing analgesic, anti-inflammatory and febrifugal effect. NSAlDs are widely used in various branches of medicine, especially at a pathology of the oporno-impellent device for knocking over of a pain after traumas, and also for symptomatic therapy of acute and chronic rheumatic diseases. Endoscopic retrograde cholangiopancreatography (ERCP) is one of the most important methods for diagnosis of diseases of the pancreatobiliary zone. ln addition to visualizing intraductal changes, this technique allows a wide range of surgical procedures, such as papillosfinkterotomiya, removal of stones, stenting and more. Unfortunately, during ERCP, serious complications may arise, primarily acute pancreatitis. To prevent the development of this pathology are offered a variety of technical and pharmacological approaches, but not all of them have proven effective in clinical trials. One of the most successful means for the prevention of post-ERCP acute pancreatitis was the use of nonsteroidal anti-inflammatory drugs. Appointment NSAlDs at carrying out ERCP - in an hour to - or is direct after procedure, essentially improves its shipping. First of all it is a question of reduction of number and reduction of weight of ERCP - associated acute pancreatitis potentially menacing to life of complication. Though in clinical researches it has not been shown authentic decrease mortality from the given pathology, nevertheless, it is necessary to think that active preventive maintenance will allow to rescue patients from the destruction caused heavy iatrogenic by a pancreatitis. This review is devoted to an analysis of published data on the subject.

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The authors declare that there are no conflicts of interest present.