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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2023-8.6.24</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-4512</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЭКСПЕРИМЕНТАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EXPERIMENTAL RESEARCHES</subject></subj-group></article-categories><title-group><article-title>Изменение паттерна нарушений сна у здоровых людей в условиях 21-суточной антиортостатической гипокинезии</article-title><trans-title-group xml:lang="en"><trans-title>Changes in the pattern of sleep disturbances in healthy subjects under 21-day antiorthostatic hypokinesia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3564-6798</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ковров</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovrov</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ковров Геннадий Васильевич – доктор медицинских наук, профессор, ведущий научный сотрудник </p><p>123007, г. Москва, Хорошевское шоссе, 76а</p></bio><bio xml:lang="en"><p>Gennady V. Kovrov – Dr.  Sc. (Med.), Professor, Senior Research Officer </p><p>Khoroshevskoe Highway 76A, Moscow 123007</p></bio><email xlink:type="simple">kgv2006@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-7901-8869</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Власова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vlasova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Власова Алиса Вадимовна – студентка, Институт клинической медицины им. Н.В. Склифосовского; лаборант </p><p>123007, г. Москва, Хорошевское шоссе, 76а;119991, г. Москва, ул. Трубецкая, 8, стр. 2</p></bio><bio xml:lang="en"><p>Alisa V. Vlasova – Student, N.V. Sklifosovsky Institute of Clinical Medicine; Research Assistant </p><p>Khoroshevskoe Highway 76A, Moscow 123007; Trubetskaya str. 8 build. 2, Moscow 119991</p></bio><email xlink:type="simple">vav.vav.va@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-3749-588X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Popova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Попова Ольга Владимировна – младший научный сотрудник </p><p>123007, г. Москва, Хорошевское шоссе, 76а</p></bio><bio xml:lang="en"><p>Olga V. Popova – Junior Research Officer </p><p>Khoroshevskoe Highway 76A, Moscow 123007</p></bio><email xlink:type="simple">olya.popovaolga2710@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2596-8929</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черникова</surname><given-names>А. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernikova</surname><given-names>A. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черникова Анна Григорьевна – кандидат биологических наук, старший научный сотрудник </p><p>123007, г. Москва, Хорошевское шоссе, 76а</p></bio><bio xml:lang="en"><p>Anna  G. Chernikova – Cand.  Sc. (Biol.), Senior Research Officer </p><p>Khoroshevskoe Highway 76A, Moscow 123007</p></bio><email xlink:type="simple">anna.impb@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУН Государственный научный центр Российской Федерации – Институт медико-биологических проблем Российской академии наук</institution></aff><aff xml:lang="en"><institution>State Scientific Center of the Russian Federation – Institute Biomedical Problems, Russian Academy of Sciences</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУН Государственный научный центр Российской Федерации – Институт медико-биологических проблем Российской академии наук;&#13;
ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)</institution></aff><aff xml:lang="en"><institution>State Scientific Center of the Russian Federation – Institute Biomedical Problems, Russian Academy of Sciences;&#13;
I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>15</day><month>01</month><year>2024</year></pub-date><volume>8</volume><issue>6</issue><fpage>241</fpage><lpage>248</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ковров Г.В., Власова А.В., Попова О.В., Черникова А.Г., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Ковров Г.В., Власова А.В., Попова О.В., Черникова А.Г.</copyright-holder><copyright-holder xml:lang="en">Kovrov G.V., Vlasova A.V., Popova O.V., Chernikova A.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/4512">https://www.actabiomedica.ru/jour/article/view/4512</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Антиортостатическая гипокинезия (АНОГ) воспроизводит некоторые эффекты воздействия невесомости на организм человека и применяется для изучения адаптации к условиям космического полёта. Известно, что АНОГ влияет на ночной сон, но в литературе отсутствуют сведения о последовательности возникновения нарушений сна при АНОГ.</p></sec><sec><title>Цель работы</title><p>Цель работы. Изучение динамики субъективных изменений оценки качества сна в условиях антиортостатической гипокинезии.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В эксперименте с 21-суточной АНОГ участвовали 6 здоровых мужчин-добровольцев (возраст от 26 до 34 лет). Они находились на медицинской кровати с углом наклона тела относительно горизонта –6° в течение 21 суток. Для оценки качества сна был использован структурированный опросник, оценивающий продолжительность сна, скорость засыпания, ночные пробуждения, наличие дневной сонливости, дневных засыпаний.</p></sec><sec><title>Результаты</title><p>Результаты. На основании оценки динамики индекса эффективности сна (ИЭС) было выделено 3 этапа адаптации. На этапе острой адаптации (первые 3  суток) происходит снижение ИЭС с  96,4 до  91,3 (p  &lt;  0,01), статистически значимое удлинение засыпания с 17,6 до 33,6 мин (p &lt; 0,01), увеличение продолжительности ночных пробуждений до 17,4 мин, усиление дневной сонливости на 11 %. В следующие 3 суток («восстановительный» этап) отмечается статистически значимое увеличение ИЭС по сравнению с  1-м этапом до  94,7 (p  &lt;  0,01), но он остаётся статистически значимо ниже фоновых значений (p &lt; 0,004). Возрастает количество жалоб на дневную сонливость (до 42 %), сроки вечернего отбоя смещаются позже на 26 минут. На 3-м этапе (оставшиеся ночи) происходит относительная стабилизация цикла «сон – бодрствование».</p></sec><sec><title>Заключение</title><p> Заключение. В условиях 21-суточной АНОГ происходит постепенное изменение паттерна нарушений сна. Наиболее негативные в плане субъективной оценки изменения отмечались в первые 3 дня. Затем отмечается улучшение засыпания, снижение ночных пробуждений в сочетании с увеличением дневной сонливости и формированием режима с более поздним отбоем.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Antiorthostatic hypokinesia (ANOH) reproduces some of the effects of weightlessness on the human body and is used to study adaptation to space flight conditions. It is known that ANOH affects nighttime sleep, but there is no information in the literature on the sequence of occurrence of sleep disorders in ANOH.</p><p>The aim of the research was to study the dynamics of subjective changes in assessing sleep quality under conditions of antiorthostatic hypokinesia.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Six healthy male volunteers (age from 26 to 34  years) participated in the experiment with 21-day ANOH. They were on a medical bed with a body inclination angle relative to the horizon of –6° for 21 days. To assess sleep quality, a structured questionnaire was used that assessed sleep duration, rate of falling asleep, night awakenings, the presence of daytime sleepiness, and daytime falling asleep.</p></sec><sec><title>Results</title><p>Results. Based on the assessment of the dynamics of the sleep efficiency index (SEI), three stages of adaptation were identified. At the stage of acute adaptation (the first 3 days), there is a decrease in SEI from 96.4 to 91.3 (p &lt; 0.01), a statistically significant prolongation of falling asleep from 17.6 to 33.6  minutes (p  &lt;  0.01), an increase duration of night awakenings up to 17.4 minutes, increase in daytime sleepiness by 11 %. In the next 3 days (the “recovery” stage), there is a statistically significant increase in SEI compared to the 1st stage to 94.7 (p &lt; 0.01), but it remains statistically significantly lower than the background values (p &lt; 0.004). The number of complaints about daytime sleepiness increases (up to 42  %), evening bedtime shifts later by 26 minutes. At the 3rd stage (the remaining nights) there is a relative stabilization of the sleep-wake cycle.</p></sec><sec><title>Conclusion</title><p>Conclusion. Under conditions of 21-day ANOH, a gradual change in the pattern of sleep disturbances occurs. The most negative changes in terms of subjective assessment were noted in the first three days. Then there is an improvement in falling asleep, a decrease in night awakenings, combined with an increase in daytime sleepiness and the formation of a schedule with a later bedtime.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>антиортостатическая гипокинезия</kwd><kwd>сон</kwd><kwd>космический полёт</kwd><kwd>индекс эффективности сна</kwd></kwd-group><kwd-group xml:lang="en"><kwd>antiorthostatic hypokinesia</kwd><kwd>sleep</kwd><kwd>space flight</kwd><kwd>sleep efficiency index</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена в рамках базовой темы РАН 64.1 на 2021–2023 гг.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Вейн A.M., Хехт К. Сон человека. Физиология и патология. 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