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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2023-8.5.13</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-4450</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТРАВМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>TRAUMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Острое повреждение почек после первичного тотального эндопротезирования тазобедренного сустава</article-title><trans-title-group xml:lang="en"><trans-title>Acute kidney injury after primary total hip replacement</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7602-6720</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедь</surname><given-names>М. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebed</surname><given-names>M. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лебедь Максим Леонидович – доктор медицинских наук, заведующий отделением анестезиологии-реанимации; ассистент кафедры анестезиологии-реаниматологии </p><p>664003, г. Иркутск, ул. Борцов Революции, 1;664003, г. Иркутск, ул. Красного Восстания, 1</p></bio><bio xml:lang="en"><p>Maksim L. Lebed – Dr. Sc. (Med.), Head of the Department of Anesthesiology and Reanimation; Teaching Assistant at the Department of Anesthesiology and Intensive Care Medicine </p><p>Bortsov Revolyutsii str. 1, Irkutsk 664003;Krasnogo Vosstaniya str. 1, Irkutsk 664003</p></bio><email xlink:type="simple">swanmax@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7755-3397</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кирпиченко</surname><given-names>М. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kirpichenko</surname><given-names>M. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кирпиченко Михаил Геннадьевич – кандидат медицинских наук, врач анестезиолог-реаниматолог отделения анестезиологии-реанимации </p><p>664003, г. Иркутск, ул. Борцов Революции, 1</p></bio><bio xml:lang="en"><p>Mikhail G. Kirpichenko – Cand. Sc. (Med.), Anesthesiologist at the Department of Anesthesiology and Reanimation </p><p>Bortsov Revolyutsii str. 1, Irkutsk 664003</p></bio><email xlink:type="simple">kirpnet@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-5860-8261</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новикова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новикова Екатерина Вячеславовна – врач анестезиолог-реаниматолог отделения анестезиологии-реанимации </p><p>664003, г. Иркутск, ул. Борцов Революции, 1</p></bio><bio xml:lang="en"><p>Ekaterina V. Novikova – Anesthesiologist at the Department of Anesthesiology and Reanimation </p><p>Bortsov Revolyutsii str. 1, Irkutsk 664003</p></bio><email xlink:type="simple">enovikova261182@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-6149-6652</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедь</surname><given-names>Т. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebed</surname><given-names>T. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лебедь Татьяна Геннадьевна – врач-уролог </p><p>664033, г. Иркутск, ул. Лермонтова, 283</p></bio><bio xml:lang="en"><p>Tatiana G. Lebed – Urologist, Clinical Hospital of the Irkutsk Scientific Centre </p><p>Lermontova str. 283, Irkutsk 664033</p></bio><email xlink:type="simple">lebedtg@list.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8701-6432</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маньков</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Mankov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Маньков Александр Викторович – кандидат медицинских наук, доцент, заведующий кафедрой анестезиологии-реаниматологии </p><p>664003, г. Иркутск, ул. Красного Восстания, 1</p></bio><bio xml:lang="en"><p>Aleksandr V. Mankov – Cand. Sc. (Med.), Docent, Head of the Department of Anesthesiology and Intensive Care Medicine </p><p>Krasnogo Vosstaniya str. 1, Irkutsk 664003</p></bio><email xlink:type="simple">man-aleksandrv@yandex.ru</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Иркутский научный центр хирургии и травматологии»;&#13;
ФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава России</institution></aff><aff xml:lang="en"><institution>Irkutsk Scientific Centre of Surgery and Traumatology;&#13;
Irkutsk State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБНУ «Иркутский научный центр хирургии и травматологии»</institution></aff><aff xml:lang="en"><institution>Irkutsk Scientific Centre of Surgery and Traumatology</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГБУЗ «Клиническая больница Иркутского научного центра Сибирского отделения Российской академии наук»</institution></aff><aff xml:lang="en"><institution>Clinical Hospital of the Irkutsk Scientific Centre, Siberian Branch of the Russian Academy of Sciences</institution></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>ФГБОУ ВО «Иркутский государственный медицинский университет» Минздрава России</institution></aff><aff xml:lang="en"><institution>Irkutsk State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>11</day><month>12</month><year>2023</year></pub-date><volume>8</volume><issue>5</issue><fpage>125</fpage><lpage>132</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лебедь М.Л., Кирпиченко М.Г., Новикова Е.В., Лебедь Т.Г., Маньков А.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Лебедь М.Л., Кирпиченко М.Г., Новикова Е.В., Лебедь Т.Г., Маньков А.В.</copyright-holder><copyright-holder xml:lang="en">Lebed M.L., Kirpichenko M.G., Novikova E.V., Lebed T.G., Mankov A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/4450">https://www.actabiomedica.ru/jour/article/view/4450</self-uri><abstract><p>Оперативные вмешательства, напрямую не затрагивающие мочевыделительную систему, могут вызывать нарушение экскреторной функции почек.</p><sec><title>Цель исследования</title><p>Цель исследования. Установить распространённость, факторы риска и  клиническую значимость острого повреждения почек после первичного эндопротезирования тазобедренного сустава у пациентов клиники ФГБНУ «Иркутский научный центр хирургии и травматологии» (ИНЦХТ).</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Ретроспективному анализу подвергнуты истории болезни 109 пациентов, которым в 2021 г. в клинике ИНЦХТ в условиях субарахноидальной анестезии выполнено оперативное вмешательство в объёме первичного тотального эндопротезирования тазобедренного сустава (ТЭТС). Результаты исследования. У 8 пациентов исследуемой группы послеоперационная динамика показателей креатинина в сыворотке крови соответствовала критериям KDIGO (The Kidney Disease: Improving Global Outcomes) острого повреждения почек (ОПП). Исходные показатели экскреторной функции почек в подгруппе ОПП были не хуже, чем во всей группе.</p><p>Статистически значимая корреляция установлена между ОПП и показателями кислородной ёмкости крови – исходной и минимальной послеоперационной концентрацией гемоглобина.</p><p>ОПП у пациентов исследуемой группы после первичного ТЭТС оказывало минимальное влияние на клиническое течение раннего послеоперационного периода. Ни одному из пациентов не потребовалось проведение заместительной почечной терапии, повторный перевод из профильного отделения в палату интенсивной терапии и реанимации, специфическое лечение. Продолжительность послеоперационного пребывания пациентов с  ОПП в клинике не увеличивалась.</p></sec><sec><title>Выводы</title><p>Выводы. Острое повреждение почек выявлено у 7,3 % пациентов, перенёсших первичное ТЭТС. Факторами риска развития послеоперационного ОПП у пациентов исследуемой группы были относительно низкие показатели исходной и минимальной послеоперационной концентрации гемоглобина крови, что может свидетельствовать в пользу преренального механизма патогенеза ОПП. Реализация основных положений «ренального протокола» у  пациентов с исходной скоростью клубочковой фильтрации более 45  мл/мин/1,73  м2 позволяет избежать развития тяжёлых клинически значимых форм послеоперационного ОПП и связанных с ним осложнений в раннем послеоперационном периоде первичного ТЭТС.</p></sec></abstract><trans-abstract xml:lang="en"><p>Surgical interventions that do not directly affect the urinary system can cause excretory dysfunction of kidneys. </p><sec><title>The aim</title><p>The aim. To establish the prevalence, risk factors and clinical significance of acute kidney injury after primary hip replacement performed in the clinic of the Irkutsk Scientific Centre of Surgery and Traumatology. </p></sec><sec><title>Materials and methods</title><p>Materials and methods. We carried out a retrospective analysis of the case histories of 109 patients who underwent primary total hip replacement under conditions of subarachnoid anesthesia in the clinic of the Irkutsk Scientific Centre of Surgery and Traumatology in 2021. </p></sec><sec><title>Results</title><p>Results. Postoperative changes in serum creatinine in 8 patients of the study group met the KDIGO (The Kidney Disease: Improving Global Outcomes) criteria for acute kidney injury. Initial indicators of renal excretory function in the subgroup with acute kidney injury were not different from those in the entire group. </p><p>Statistically significant correlation was established between acute kidney injury and indicators of oxygen-carrying capacity of blood – initial and minimal postoperative hemoglobin concentration. </p><p>Acute kidney injury in patients of the study group had a minimal effect on the clinical course of the early postoperative period. None of the patients required renal replacement therapy, re-transfer from the specialized unit to the intensive care unit or any specific treatment. The duration of postoperative stay of patients with acute kidney injury in the clinic did not increase. </p></sec><sec><title>Conclusions</title><p>Conclusions. Acute kidney injury was detected in 7.3  % of patients who underwent primary total hip replacement. Risk factors for the development of postoperative acute kidney injury in  patients of the study group included relatively low initial and  minimal postoperative blood hemoglobin concentrations, which may indicate prerenal mechanism of acute kidney injury pathogenesis. Implementation of the main steps of the “renal protocol” in patients with initial glomerular filtration rate over 45 ml/min/1.73 m2 allows avoiding the development of severe clinically significant forms of postoperative acute kidney injury and complications associated with it in the early postoperative period of primary total hip replacement.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>острое повреждение почек</kwd><kwd>первичное эндопротезирование тазобедренного сустава</kwd><kwd>концентрация гемоглобина крови</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute kidney injury</kwd><kwd>primary hip replacement</kwd><kwd>blood hemoglobin concentration</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lee YJ, Park BS, Park S, Park JH, Kim IH, Ko J, et al. Analysis of the risk factors of acute kidney injury after total hip or knee replacement surgery. 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