actabiomedicaActa Biomedica ScientificaActa Biomedica Scientifica2541-94202587-9596Scientific Centre for Family Health and Human Reproduction Problems10.29413/ABS.2023-8.5.4actabiomedica-4436Research ArticleМИКРОБИОЛОГИЯ И ВИРУСОЛОГИЯMICROBIOLOGY AND VIRUSOLOGYАнтимикробный потенциал йодсодержащих веществ и материаловAntimicrobial potential of iodine-containing substances and materialshttps://orcid.org/0000-0002-1551-5440НевежинаА. В.NevezhinaA. V.

Невежина Анна Владимировна – младший научный сотрудник лаборатории клеточных технологий и регенеративной медицины 

664003, г. Иркутск, ул. Борцов Революции, 1

Anna V. Nevezhina – Junior Research Officer at the Laboratory of Cell Technologies and Regenerative Medicine 

Bortsov Revolyutsii str. 1, Irkutsk 664003

n4nnna@yandex.ruhttps://orcid.org/0000-0002-4681-905XФадееваТ. В.FadeevaT. V.

Фадеева Татьяна Владимировна – доктор биологических наук, ведущий научный сотрудник лаборатории клеточных технологий и регенеративной медицины 

664003, г. Иркутск, ул. Борцов Революции, 1

Tatiana  V. Fadeeva – Dr.  Sc. (Biol.), Leading Research Officer at the Laboratory of Cell Technologies and Regenerative Medicine 

Bortsov Revolyutsii str. 1, Irkutsk 664003

fadeeva05@yandex.ruФГБНУ «Иркутский научный центр хирургии и травматологии»Irkutsk Scientific Centre of Surgery and Traumatology202306122023853649Copyright © Невежина А.В., Фадеева Т.В., 20232023Невежина А.В., Фадеева Т.В.Nevezhina A.V., Fadeeva T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.actabiomedica.ru/jour/article/view/4436

Несмотря на поиск и разработку новых антимикробных препаратов с антибиотическими или  антисептическими свойствами, распространение полирезистентных штаммов микроорганизмов по-прежнему остаётся серьёзной проблемой в лечении и профилактике инфекционных заболеваний (раневые, послеоперационные и ожоговые инфекции, предоперационная обработка операционного и инъекционного поля пациента, гигиеническая обработка рук хирургов, медицинского персонала и т. д.). Настоящий обзор современных отечественных и зарубежных литературных источников посвящён анализу данных о перспективах применения веществ и материалов с йодом и йодидами в качестве антимикробных агентов. В современных условиях возрастающее количество научных работ посвящены изучению и разработке различных препаратов, обладающих характеристиками, специфичными для их применения. Антимикробные соединения с йодом могут быть применены к широкому спектру материалов, таких как текстиль, пластик, металлы, керамика, что позволяет этим материалам быть устойчивыми к микробному росту и росту биоплёнок. Обобщены литературные данные по высокой антимикробной активности йода как в нейтральных носителях, так и в синергии с уже обладающими подобными свойствами веществами. Такие комплексные препараты в значительной мере теряют токсичность, действуя пролонгировано с сохранением своих свойств. Основные механизмы противомикробного воздействия йода и соединений с йодом предопределяет их сильная окислительная способность. Обращено внимание на спектр активности препаратов йода. Наряду с антимикробным эффектом, они могут способствовать процессам регенерации. В  целом инновационные препараты с йодом с антибактериальными и фунгицидными свойствами перспективны для медицинских и других целей.

Despite the search and development of new antimicrobial drugs with antibiotic or antiseptic properties, the spread of multidrug-resistant strains of microorganisms remains a serious problem in the treatment and prevention of infectious diseases (wound, postoperative and burn infections, preoperative preparation of the surgical and injection fields, hygienic disinfection of the hands of surgeons, medical personnel, etc.). This review of modern domestic and foreign literature sources is devoted to the analysis of data on the prospects of using antiseptics with iodine and iodides as antimicrobial agents. In modern conditions, there is an increasing number of scientific works devoted to the study and development of various drugs, distinguished by their diversity and their specific application. Antimicrobial iodine-containing compounds can be applied to a wide range of  materials such as textile, plastics, metals, ceramics to make them resistant to microbial and biofilm growth. The article summarized the literature data on the high antimicrobial activity of  iodine both in neutral carriers and in synergy with substances already possessing similar properties. Such complex preparations lose their toxicity to a large extent, having prolonged action with the preservation of their properties. The main mechanisms of antimicrobial action of iodine and iodine compounds are determined by their strong oxidizing ability. Attention is drawn to the spectrum of activity of iodine preparations. Along with the antimicrobial effect, they can promote regeneration processes. In general, innovative iodine preparations with antibacterial and fungicidal properties are promising for medical and other purposes.

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The authors declare that there are no conflicts of interest present.