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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2023-8.4.13</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-4343</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КАРДИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CARDIOLOGY</subject></subj-group></article-categories><title-group><article-title>Диастолическая дисфункция левого желудочка и параметры трансмитрального кровотока у лиц, перенёсших COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Left ventricular diastolic dysfunction and transmitral blood flow parameters in patients after COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7164-4274</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильев</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasilev</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Васильев Валерий Анатольевич – кандидат медицинских наук, доцент кафедры лучевой диагностики и лучевой терапии с курсом критической и респираторной медицины </p><p>185910, г. Петрозаводск, пр. Ленина, 33</p></bio><bio xml:lang="en"><p>Valeriy A. Vasilev – Cand. Sc. (Med.), Associate Professor at the Department of X-Ray Diagnostics and Radiation Therapy with a Course of Critical and Respiratory Medicine </p><p>Lenina ave. 33, Petrozavodsk 185910</p></bio><email xlink:type="simple">valerij-vasiljev@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-7166-0013</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Карапетян</surname><given-names>Т. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Karapetyan</surname><given-names>T. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Карапетян Тея Тамазовна – студентка 5-го курса </p><p>185910, г. Петрозаводск, пр. Ленина, 33</p></bio><bio xml:lang="en"><p>Teya T. Karapetyan – 5th year Student </p><p>Lenina ave. 33, Petrozavodsk 185910</p></bio><email xlink:type="simple">teya281200@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-6508-4261</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ларионова</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Larionova</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ларионова Вера Александровна – врач ультразвуковой диагностики </p><p>185001, г. Петрозаводск, пр. Первомайский, 17</p></bio><bio xml:lang="en"><p>Vera A. Larionova – Ultrasound Medical Investigation Specialist </p><p>Pervomaisky ave. 17, Petrozavodsk 185001</p></bio><email xlink:type="simple">V.a.larionova@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-6745-7480</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соляникова</surname><given-names>И. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Solyanikova</surname><given-names>I. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соляникова Ирина Николаевна – врач ультразвуковой диагностики </p><p>185001, г. Петрозаводск, пр. Первомайский, 17</p></bio><bio xml:lang="en"><p>Irina N. Solyanikova – Ultrasound Medical Investigation Specialist </p><p>Pervomaisky ave. 17, Petrozavodsk 185001</p></bio><email xlink:type="simple">irina041270@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0000-1104-3522</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цеханович</surname><given-names>К. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsekhanovich</surname><given-names>K. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Цеханович Константин Борисович – заведующий отделением ультразвуковой диагностики, врач ультразвуковой диагностики </p><p>185001, г. Петрозаводск, пр. Первомайский, 17</p></bio><bio xml:lang="en"><p>Konstantin  B. Tsekhanovich – Head of the Department of Ultrasound Diagnostics, Ultrasound Medical Investigation Specialist </p><p>Pervomaisky ave. 17, Petrozavodsk 185001</p></bio><email xlink:type="simple">konsttseh@icloud.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Петрозаводский государственный университет»</institution></aff><aff xml:lang="en"><institution>Petrozavodsk State University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ЧУЗ «Клиническая больница «РЖД-Медицина» города Петрозаводск»</institution></aff><aff xml:lang="en"><institution>Clinical Hospital «RZhD-Meditsina» of Petrozavodsk</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>03</day><month>10</month><year>2023</year></pub-date><volume>8</volume><issue>4</issue><fpage>117</fpage><lpage>125</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Васильев В.А., Карапетян Т.Т., Ларионова В.А., Соляникова И.Н., Цеханович К.Б., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Васильев В.А., Карапетян Т.Т., Ларионова В.А., Соляникова И.Н., Цеханович К.Б.</copyright-holder><copyright-holder xml:lang="en">Vasilev V.A., Karapetyan T.T., Larionova V.A., Solyanikova I.N., Tsekhanovich K.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/4343">https://www.actabiomedica.ru/jour/article/view/4343</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. У лиц, перенёсших инфекцию COVID-19, имеется повышенный риск развития заболеваний сердечно-сосудистой системы. Диастолическая дисфункция левого желудочка является ранним маркером развития кардиологической патологии. Её своевременное выявление имеет важное значение для назначения адекватной терапии и динамического наблюдения за пациентами. В связи с этим представляется актуальным исследование влияния перенесённой инфекции COVID-19 на диастолическую функцию левого желудочка и показатели трансмитрального кровотока у практически здоровых лиц при отсутствии у них клинико-инструментальных признаков сердечно-сосудистой патологии. </p></sec><sec><title>Цель исследования</title><p>Цель исследования. Оценка изменений диастолической и систолической функции левого желудочка, его анатомических параметров и показателей трансмитрального кровотока в двух группах практически здоровых лиц: перенёсших и не перенёсших инфекцию COVID-19. </p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведена трансторакальная эхокардиография по стандартной методике и проанализированы её результаты у 66 обследованных, признанных практически здоровыми по результатам регулярных комплексных клинико-инструментальных исследований. В первую группу были включены 30  лиц, прошедших эхокардиографическое исследование до пандемии COVID-19 или в период пандемии, но не болевшие коронавирусной инфекцией; вторую группу составили 36 лиц, переболевшие COVID-19. Оценивались показатели, свидетельствующие о наличии диастолической дисфункции левого желудочка, и параметры трансмитрального потока крови. Исследование одобрено на заседании Комитета по медицинской этике при Министерстве здравоохранения Республики Карелия и ФГБОУ ВО «Петрозаводский государственный университет» (протокол № 47 от 11.01.2023). </p></sec><sec><title>Результаты</title><p>Результаты. Частота выявления диастолической дисфункции левого желудочка не отличалась в первой и второй группах пациентов. Зарегистрированы статистически значимые различия в средних показателях времени замедления потока как раннего, так и позднего наполнения левого желудочка у лиц, перенёсших и не перенёсших инфекцию COVID-19. Изменение фазовой структуры трансмитрального кровотока может быть ранним проявлением нарушений внутрисердечной гемодинамики у лиц, переболевших COVID-19.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. People who previously had COVID-19 infection have an increased risk of developing cardiovascular diseases. Left ventricular diastolic dysfunction is an early marker of the development of cardiac pathology. Its early detection is important for the adequate therapy order and dynamic monitoring of patients. In this regard, it seems relevant to study the effect of a recent COVID-19 infection on the left ventricular diastolic function and transmitral blood flow parameters in apparently healthy individuals without clinical and instrumental signs of cardiovascular pathology. </p></sec><sec><title>The aim of the study</title><p>The aim of the study. To assess the changes in the diastolic and systolic function of  the left ventricle, its anatomical parameters and transmitral blood flow parameters in two groups of  apparently healthy individuals: those who had and those who had not COVID-19 infection. </p></sec><sec><title>Materials and methods</title><p>Materials and methods. Transthoracic echocardiography was performed according to the standard technique and its results were analyzed in 66 examined patients who were recognized as apparently healthy according to the results of  regular comprehensive clinical and instrumental studies. The first group included 30 individuals who underwent an echocardiographic study before or during the COVID-19 pandemic, but did not have a coronavirus infection; the second group consisted of 36 people who recovered from COVID-19. The indicators of the presence of left ventricular diastolic dysfunction and the transmitral blood flow parameters were assessed. The study was approved at a meeting of the Medical Ethics Committee under the Ministry of Health of the Republic of Karelia and of Petrozavodsk State University (Minutes No. 47 of 01.11.2023). </p></sec><sec><title>Results</title><p>Results. The frequency of the left ventricular diastolic dysfunction did not differ in  the  first and second groups of patients. Statistically significant differences were recorded in the average flow deceleration time for both early and late filling of the left ventricle in people who had and did not have COVID-19 infection. A change in the phase structure of the transmitral blood flow may be an early manifestation of intracardiac hemodynamic disorders in people who have recovered from COVID-19.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>диастолическая функция</kwd><kwd>левый желудочек</kwd><kwd>трансмитральный кровоток</kwd><kwd>эхокардиография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>diastolic function</kwd><kwd>left ventricle</kwd><kwd>transmitral blood flow</kwd><kwd>echocardiography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Цыганова Е.В., Глухоедова Н.В., Жиленкова А.С., Федосеева Т.И., Ющук Е.Н., Сметнева Н.С. 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