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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2023-8.3.13</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-4215</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>НЕВРОЛОГИЯ И НЕЙРОХИРУРГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NEUROLOGY AND NEUROSURGERY</subject></subj-group></article-categories><title-group><article-title>Факторы риска развития сосудистой деменции</article-title><trans-title-group xml:lang="en"><trans-title>Risk factors for vascular dementia</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6322-5122</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванова Людмила Александровна – кандидат медицинских наук, доцент кафедры психиатрии и наркологии</p><p>664079, г. Иркутск, Юбилейный, 100, Россия </p></bio><bio xml:lang="en"><p>Lyudmila A. Ivanova – Сand. Sc. (Мed.), Associate Professor at the Department of Psychiatry and Addictology</p><p> Yubileyniy 100, Irkutsk 664079, Russian Federation </p></bio><email xlink:type="simple">ivanova.l@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Иркутская государственная медицинская академия последипломного образования – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff><aff xml:lang="en"><institution>Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education </institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>11</day><month>07</month><year>2023</year></pub-date><volume>8</volume><issue>3</issue><fpage>121</fpage><lpage>129</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Иванова Л.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Иванова Л.А.</copyright-holder><copyright-holder xml:lang="en">Ivanova L.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/4215">https://www.actabiomedica.ru/jour/article/view/4215</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Прогнозируется увеличение количества людей пожилого возраста с когнитивными расстройствами, в том числе с деменцией.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Изучение факторов риска развития сосудистой деменции.</p></sec><sec><title>Методы</title><p>Методы. Обследованы 39 пациентов с сосудистой деменцией (F01 по МКБ-10); средний возраст – 75,2 ± 9,9 года. Группу сравнения составили 167 человек, посещающие школы памяти, у которых выявлено снижение когнитивных функций (средний возраст – 70,01 ± 3,03 года. По шкале MMSE (Mini Mental State Examination) умеренная степень деменции выявлена в 56,4 % случаев, тяжёлая – в 43,6 %; в группе сравнения в 94 % случаев отмечены лёгкие и в 6 % – умеренные когнитивные нарушения.</p></sec><sec><title>Результаты</title><p>Результаты. В группе сосудистой деменции статистически значимо чаще выявлялись: ишемическая болезнь сердца (ИБС) в возрасте 70–79 лет (57,1 %; р = 0,000) и в группе в целом (56,4 %; р = 0,000); сахарный диабет в возрасте 60–69 лет (100 %; р = 0,005); артериальная гипертензия (АГ) в возрасте 70–79 лет (100 %; р = 0,000) и в группе в целом (87,2 %; р = 0,000). В группе сравнения частота индекса массы тела (ИМТ) более 25 была статистически значимо выше в возрасте 70–79 лет (60 %; р = 0,000), 80 лет и старше (64,3 %; р = 0,037) и в группе в целом (68,9 %; р = 0,000). Среди лиц с умеренными когнитивными расстройствами статистически значимо чаще встречались: ИБС в возрасте 60–69 лет (10 %; р = 0,001), сахарный диабет в возрасте 70–79 лет (40 %; р = 0,025) и в группе в целом (50 %; р = 0,033), ИМТ более 25 в возрасте 80 лет и старше (70 %; р = 0,000) и в группе в целом (100 %; р = 0,000). Общим фактором риска как для пациентов с сосудистой деменцией, так и для группы с умеренными когнитивными расстройствами оказался возраст 80 лет и старше (20,5 % (р = 0,027) и 70 % (р = 0,005) соответственно).</p></sec><sec><title>Заключение</title><p>Заключение. Факторы риска развития когнитивных нарушений – ИБС, АГ, сахарный диабет, избыточная масса тела – являются потенциально обратимыми; их своевременное выявление позволит уменьшить развитие когнитивных расстройств и деменции.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. An increase in the number of older people with cognitive disorders, including dementia, is expected.</p></sec><sec><title>The aim</title><p>The aim. To study the risk factors for vascular dementia.</p></sec><sec><title>Material and methods</title><p>Material and methods. 39 patients with vascular dementia (ICD-10 diagnosis code F01) were examined. The comparison group consisted of 167 people. According to the MMSE (Mini Mental State Examination) scale, moderate dementia was detected in 56.4 % of cases, severe – in 43.6 %; in the comparison group, 94 % had mild and 6 % – moderate cognitive impairment.</p></sec><sec><title>Results</title><p>Results. In the vascular dementia group, the following risk factors were registered significantly more often: ischemic heart disease – at the age of 70–79 years (57.1 %; p = 0.000) and in the group as a whole (56.4 %; p = 0.000); diabetes mellitus – at the age of 60–69 years (100 %; p = 0.005); arterial hypertension – at the age of 70–79 years (100 %; p = 0.000) and in the group as a whole (87.2 %; p = 0.000). In the comparison group, the frequency of body mass index over 25 was significantly higher at the age of 70–79 years (60 %; p = 0.000), 80 years and older (64.3 %; p = 0.037) and in the group as a whole (68.9 %; p = 0.000). Among people with moderate cognitive impairment, the following risk factors were significantly more common: coronary heart disease – at the age of 60–69 years (10 %; p = 0.001); diabetes mellitus – at the age of 70–79 years (40 %; p = 0.025) and in the group as a whole (50 %; p = 0.033), the frequency of body mass index over 25 – at the age of 80 years and older (70 %; p = 0.000) and in the group as a whole (100 %; p = 0.000).</p></sec><sec><title>Conclusion</title><p>Conclusion. Risk factors for the development of cognitive disorders (coronary heart disease, hypertension, diabetes mellitus, overweight) are potentially reversible; their timely detection can reduce the development of cognitive disorders and dementia.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>когнитивные нарушения</kwd><kwd>сосудистая деменция</kwd><kwd>факторы риска</kwd><kwd>профилактика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cognitive impairment</kwd><kwd>vascular dementia</kwd><kwd>risk factors</kwd><kwd>prevention</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Курбанова М.М., Галаева А.А., Стефановская Е.В., Суворкина А.А., Алиханов Н.М. Современные методы диагностики когнитивных нарушений. 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