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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2023-8.3.10</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-4212</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>МОРФОЛОГИЯ, ФИЗИОЛОГИЯ И ПАТОФИЗИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>MORPHOLOGY, PHYSIOLOGY AND PATHOPHYSIOLOGY</subject></subj-group></article-categories><title-group><article-title>Влияние обонятельного и вкусового восприятия на метаболический гомеостаз у пациентов с ожирением</article-title><trans-title-group xml:lang="en"><trans-title>The impact of olfactory and gustatory perception on metabolic homeostasis in obese patients</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2667-4842</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Самойлова</surname><given-names>Ю. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Samoilova</surname><given-names>Iu. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Самойлова Юлия Геннадьевна – доктор медицинских наук, профессор, заведующая кафедрой педиатрии с курсом эндокринологии</p><p>634050, г. Томск, Московский тракт, 2, Россия </p></bio><bio xml:lang="en"><p>Iuliia G. Samoilova – Dr. Sc. (Med.), Professor, Head of the Department of Pediatrics with a Course of Endocrinology</p><p>Moskovsky trakt 2, Tomsk 634050, Russian Federation </p><p> </p></bio><email xlink:type="simple">samoilova_y@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6212-4568</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Подчиненова</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Podchinenova</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Подчиненова Дарья Васильевна – кандидат медицинских наук, доцент кафедры педиатрии с курсом эндокринологии</p><p>634050, г. Томск, Московский тракт, 2, Россия </p></bio><bio xml:lang="en"><p>Daria V. Podchinenova – Cand. Sc. (Med.), Associate Professor at the Department of Pediatrics with a Course of Endocrinology </p><p>Moskovsky trakt 2, Tomsk 634050, Russian Federation </p></bio><email xlink:type="simple">darvas_42@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9966-6686</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Матвеева</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Matveeva</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Матвеева Мария Владимировна – доктор медицинских наук, профессор кафедры педиатрии с курсом  эндокринологии</p><p>634050, г. Томск, Московский тракт, 2, Россия </p></bio><bio xml:lang="en"><p>Mariia V. Matveeva – Dr. Sc. (Med.), Professor at the Department of Pediatrics  with a Course of Endocrinology </p><p>Moskovsky trakt 2, Tomsk 634050, Russian Federation </p></bio><email xlink:type="simple">matveeva.mariia@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1878-4467</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудлай</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudlay</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кудлай Дмитрий Анатольевич – доктор медицинских наук, член-корр. РАН, профессор кафедры фармакологии Института фармации; ведущий научный сотрудник лаборатории персонализированной медицины и молекулярной иммунологии № 71</p><p>119991, г. Москва, ул. Трубецкая, 8, стр. 2, Россия</p><p>115522, г. Москва, Каширское шоссе, 24, Россия </p></bio><bio xml:lang="en"><p>Dmitry A. Kudlay – Dr. Sc. (Med.), Corresponding Member of the RAS, Professor at the Department of Pharmacology; Leading Research Officer at the Laboratory of Personalized Medicine and Molecular Immunology No. 71</p><p>Trubetskaya str. 8 building 2, Moscow 119991, Russian Federation </p><p>Kashirskoe highway 24, Moscow 115522, Russian Federation </p></bio><email xlink:type="simple">d624254@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2915-384X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Олейник</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Oleynik</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Олейник Оксана Алексеевна – кандидат медицинских наук, доцент кафедры педиатрии с курсом  эндокринологии</p><p>634050, г. Томск, Московский тракт, 2, Россия </p></bio><bio xml:lang="en"><p>Oxana A. Oleynik – Cand. Sc. (Med.), Associate Professor at the Department of Pediatrics with a Course of Endocrinology </p><p>Moskovsky trakt 2, Tomsk 634050, Russian Federation </p></bio><email xlink:type="simple">oleynikoa@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2888-5539</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Толмачев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tolmachev</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Толмачев Иван Владиславович – кандидат медицинских наук, доцент кафедры медицинской и биологической кибернетики,</p><p>634050, г. Томск, Московский тракт, 2, Россия </p></bio><bio xml:lang="en"><p>Ivan V. Tolmachev – Cand. Sc. (Med.), Associate Professor at the Department of Medical and Biological Cybernetics </p><p>Moskovsky trakt 2, Tomsk 634050, Russian Federation </p></bio><email xlink:type="simple">ivantolm@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9748-482X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каверина</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaverina</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Каверина Ирина Сергеевна – научный сотрудник научно-образовательной лаборатории  «Бионические цифровые платформы»</p><p>634050, г. Томск, Московский тракт, 2, Россия </p></bio><bio xml:lang="en"><p> Irina S. Kaverina – Research Officer at the Scientific and Educational Laboratory “Bionic Digital Platforms” </p><p>Moskovsky trakt 2, Tomsk 634050, Russian Federation </p></bio><email xlink:type="simple">kaverina.is@ssmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6384-1972</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вачадзе</surname><given-names>Т. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Vachadze</surname><given-names>T. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вачадзе Тамара Джамбуловна – ординатор кафедры педиатрии с курсом эндокринологии</p><p>634050, г. Томск, Московский тракт, 2, Россия </p></bio><bio xml:lang="en"><p>Tamara D. Vachadze – Resident at the Department of Pediatrics with a Course of Endocrinology </p><p>Moskovsky trakt 2, Tomsk 634050, Russian Federation </p></bio><email xlink:type="simple">vtooma@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5012-0364</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коваренко</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kovarenko</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коваренко Маргарита Анатольевна – кандидат медицинских наук, ассистент кафедры педиатрии с курсом эндокринологии</p><p>634050, г. Томск, Московский тракт, 2, Россия </p></bio><bio xml:lang="en"><p>Margarita A. Kovarenko – Cand. Sc. (Med.), Teaching Assistant at the Department of Pediatrics with a Course of Endocrinology </p><p>Moskovsky trakt 2, Tomsk 634050, Russian Federation </p></bio><email xlink:type="simple">grun-wald@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8836-0814</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Логинова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Loginova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Логинова Ольга Александровна – ординатор кафедры общей врачебной практики и поликлинической терапии</p><p>634050, г. Томск, Московский тракт, 2, Россия </p></bio><bio xml:lang="en"><p>Olga A. Loginova – Resident at the Department of General Medicine and Outpatient Therapy </p><p>Moskovsky trakt 2, Tomsk 634050, Russian Federation </p></bio><email xlink:type="simple">olgaprk2307@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава России</institution></aff><aff xml:lang="en"><institution>Siberian State Medical University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский Университет);&#13;
ФГБУ «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства</institution></aff><aff xml:lang="en"><institution>Institute of Pharmacy, I.M. Sechenov First Moscow State Medical University of the Ministry of Health Care of Russian Federation (Sechenov University); National Research Center – Institute of Immunology, Federal Medical and  Biological Agency of Russia</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>11</day><month>07</month><year>2023</year></pub-date><volume>8</volume><issue>3</issue><fpage>96</fpage><lpage>105</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Самойлова Ю.Г., Подчиненова Д.В., Матвеева М.В., Кудлай Д.А., Олейник О.А., Толмачев И.В., Каверина И.С., Вачадзе Т.Д., Коваренко М.А., Логинова О.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Самойлова Ю.Г., Подчиненова Д.В., Матвеева М.В., Кудлай Д.А., Олейник О.А., Толмачев И.В., Каверина И.С., Вачадзе Т.Д., Коваренко М.А., Логинова О.А.</copyright-holder><copyright-holder xml:lang="en">Samoilova I.G., Podchinenova D.V., Matveeva M.V., Kudlay D.A., Oleynik O.A., Tolmachev I.V., Kaverina I.S., Vachadze T.D., Kovarenko M.A., Loginova O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/4212">https://www.actabiomedica.ru/jour/article/view/4212</self-uri><abstract><p>В настоящее время ожирение представляет собой серьёзную глобальную проблему общественного здравоохранения. В результате в последние десятилетия наблюдается рост интереса к изучению влияния этого заболевания на функционирование центральной нервной системы. К одному из наименее изученных аспектов можно отнести влияние, которое ожирение оказывает на сенсорные системы.</p><p>Системы обоняния и вкуса тесно связаны с различными жизненно важными функциями, такими как активация защитных механизмов организма, стимуляция пищеварительных рефлексов. Кроме того, известно, что данные сенсорные системы играют важную роль в механизмах потребления пищи за счёт регуляции аппетита и насыщения, влияния на выбор продуктов и, следовательно, участвуют в развитии ожирения. Ряд клинических исследований продемонстрировали, что пациенты с ожирением чаще страдают от гипосмии по сравнению с худыми людьми того же возраста.</p><p>Причины, по которым существует эта взаимосвязь, во многом остаются неясными. Целью данного обзора является оценка имеющихся данных по этой тематике и определение новых перспективных областей для дальнейших исследований. Обзор проведён в базах PubMed за 2017–2023 гг.</p></abstract><trans-abstract xml:lang="en"><p>Obesity is currently a major global public health problem. As a result, in recent decades there has been a growing interest in studying the impact of this disease on the functioning of the central nervous system. One of the least understood aspects is the impact that obesity has on sensory systems.</p><p>The olfactory and gustatory systems are closely related to various vital functions, such as the nocifensors activation, the stimulation of digestive reflexes. In addition, these sensory systems are known to play an important role in the mechanisms of food consumption through the regulation of appetite and satiety, influencing food choice and, therefore, they are involved in the development of obesity. A number of clinical studies have shown that obese patients are more likely to suffer from hyposmia compared to lean people of the same age.</p><p>The reasons why this relationship exists remain largely unclear. The aim of this review is to assess the available data on this topic and to identify new promising areas for further research. The review was conducted in the PubMed databases for 2017–2023.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ожирение</kwd><kwd>обоняние</kwd><kwd>вкус</kwd><kwd>сенсорные системы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>obesity</kwd><kwd>olfaction</kwd><kwd>taste</kwd><kwd>sensory systems</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. WHO European Regional Obesity Report 2022. 2022.</mixed-citation><mixed-citation xml:lang="en">World Health Organization. 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