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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2023-8.3.6</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-4208</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ВНУТРЕННИЕ БОЛЕЗНИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INTERNAL DISEASES</subject></subj-group></article-categories><title-group><article-title>Влияние санаторно-курортного лечения на уровень системного воспаления у пациентов, перенёсших новую коронавирусную инфекцию</article-title><trans-title-group xml:lang="en"><trans-title>Influence of health resort treatment on the level of systemic inflammation in patients after new coronavirus infection</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9640-754X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белоглазов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Beloglazov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Белоглазов Владимир Алексеевич – доктор медицинских наук, заведующий кафедрой  внутренней медицины № 2</p><p>295000, Республика Крым, г. Симферополь, б-р Ленина, 5-7, Россия </p></bio><bio xml:lang="en"><p>Vladimir A. Beloglazov – Dr. Sc. (Med.), Head of the Department of Internal Medicine No. 2</p><p>Lenina Blvd. 5-7, Simferopol 295000, Republic of Crimea, Russian Federation </p></bio><email xlink:type="simple">biloglazov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1506-4758</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дудченко</surname><given-names>Л. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Dudchenko</surname><given-names>L. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дудченко Лейла Шамилевна – доктор медицинских наук, заведующая научно-исследовательским  отделом пульмонологии</p><p>298603, Республика Крым, г. Ялта, ул. Мухина, 10/3, Россия </p></bio><bio xml:lang="en"><p>Leyla Sh. Dudchenko – Dr. Sc. (Med.), Head of the Pulmonology Research Department</p><p>Mukhina str. 10/3, Yalta 298603, Republic of Crimea, Russian Federation </p></bio><email xlink:type="simple">vistur@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5486-7262</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яцков</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Yatskov</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Яцков Игорь Анатольевич – кандидат медицинских наук, ассистент кафедры внутренней медицины № 2</p><p>295000, Республика Крым, г. Симферополь, б-р Ленина, 5-7, Россия </p></bio><bio xml:lang="en"><p>Igor A. Yatskov – Cand. Sc. (Med.), Teaching Assistant at the Department of Internal Medicine No. 2</p><p>Lenina Blvd. 5-7, Simferopol 295000, Republic of Crimea, Russian Federation </p></bio><email xlink:type="simple">egermd@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7882-8885</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соловьева</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Solovyova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соловьёва Елена Александровна – научный сотрудник научно-исследовательского отдела пульмонологии</p><p>298603, Республика Крым, г. Ялта, ул. Мухина, 10/3, Россия </p></bio><bio xml:lang="en"><p>Elena A. Solovyova – Research Officfer at the Pulmonology Research Department</p><p>Mukhina str. 10/3, Yalta 298603, Republic of Crimea, Russian Federation </p></bio><email xlink:type="simple">elenasolovjova0507@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9717-7782</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шадчнева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shadchneva</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шадчнева Наталья Александровна – кандидат медицинских наук, доцент кафедры внутренней медицины № 2</p><p>295000, Республика Крым, г. Симферополь, б-р Ленина, 5-7, Россия </p></bio><bio xml:lang="en"><p>Natalia A. Shadchneva – Cand. Sc. (Med.), Associate Professor at the Department of Internal Medicine No. 2</p><p>Lenina Blvd. 5-7, Simferopol 295000, Republic of Crimea, Russian Federation </p></bio><email xlink:type="simple">shadchneva@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6161-6058</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беляева</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Belyaeva</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Беляева Светлана Николаевна – старший научный сотрудник научно-исследовательского отдела пульмонологии</p><p>298603, Республика Крым, г. Ялта, ул. Мухина, 10/3, Россия </p></bio><bio xml:lang="en"><p>Svetlana N. Belyaeva – Senior Research Officer at the Pulmonology Research Department</p><p>Mukhina str. 10/3, Yalta 298603, Republic of Crimea, Russian Federation </p></bio><email xlink:type="simple">belyaeva-sveta@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5742-1912</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ульянова</surname><given-names>Д. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ulyanova</surname><given-names>D. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ульянова Дарья Ильинична – студентка кафедры внутренней медицины № 2, Институт «Медицинская академия имени С.И. Георгиевского»</p><p>295000, Республика Крым, г. Симферополь, б-р Ленина, 5-7, Россия </p></bio><bio xml:lang="en"><p>Darya I. Ulyanova – Student at the Department of Internal Medicine No. 2</p><p>Lenina Blvd. 5-7, Simferopol 295000, Republic of Crimea, Russian Federation </p></bio><email xlink:type="simple">fisiaarmcor@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт «Медицинская академия имени С.И. Георгиевского», ФГАОУ ВО «Крымский федеральный университет имени В.И. Вернадского»</institution></aff><aff xml:lang="en"><institution>Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean Federal University</institution></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ РК «Академический научно-исследовательский институт физических методов лечения, медицинской климатологии и реабилитации имени И.М. Сеченова»</institution></aff><aff xml:lang="en"><institution>I.M. Sechenov Academic Research Institute of Physical Treatment Methods, Medical Climatology and Rehabilitation</institution></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Институт «Медицинская академия имени С.И. Георгиевского», ФГАОУ ВО «Крымский федеральный университет имени В.И. Вернадского»</institution></aff><aff xml:lang="en"><institution>Medical Academy named after S.I. Georgievsky, V.I. Vernadsky Crimean  Federal University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>11</day><month>07</month><year>2023</year></pub-date><volume>8</volume><issue>3</issue><fpage>63</fpage><lpage>69</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Белоглазов В.А., Дудченко Л.Ш., Яцков И.А., Соловьева Е.А., Шадчнева Н.А., Беляева С.Н., Ульянова Д.И., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Белоглазов В.А., Дудченко Л.Ш., Яцков И.А., Соловьева Е.А., Шадчнева Н.А., Беляева С.Н., Ульянова Д.И.</copyright-holder><copyright-holder xml:lang="en">Beloglazov V.A., Dudchenko L.S., Yatskov I.A., Solovyova E.A., Shadchneva N.A., Belyaeva S.N., Ulyanova D.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/4208">https://www.actabiomedica.ru/jour/article/view/4208</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Низкоинтенсивное воспаление (НИВ) на данный момент является одним из главных факторов риска развития неблагоприятных событий со стороны сердечно-сосудистой системы, включая смерть от сердечно-сосудистых заболеваний или их осложнений, обуславливающих смертность в постковидном периоде.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Оценить влияние санаторно-курортного лечения в условиях Южного берега Крыма на клинические и функциональные показатели, а также на уровень системного воспаления у пациентов, перенёсших новую коронавирусную инфекцию.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Обследовано 67 пациентов (возраст – 54,9 ± 9,05 года) в постковидном периоде, проходивших санаторно-курортное лечение в ГБУЗ РК «Академический научно-исследовательский институт физических методов лечения, медицинской климатологии и реабилитации имени И.М. Сеченова». Методы санаторно-курортного лечения включали климатотерапию на Южном берегу Крыма, лечебную дыхательную гимнастику, терренкуры, различные методы респираторной терапии. Всем пациентам было проведено исследование уровня С-реактивного белка (CРБ) в периферической крови при поступлении и на момент выписки.</p></sec><sec><title>Результаты</title><p>Результаты. Несмотря на статистически значимое улучшение большинства клинических и функциональных показателей, уровень СРБ и количество лейкоцитов и их субпопуляций в периферической крови у пациентов, прошедших санаторно-курортное лечение, статистически значимо не отличались (p &gt; 0,05) от исходных показателей, полученных в день поступления в ГБУЗ РК «Академический научно-исследовательский институт физических методов лечения, медицинской климатологии и реабилитации имени И.М. Сеченова». Показатель СРБ при поступлении и выписке соответствовал нижней границе интервала, характерного для НИВ (от 3 до 10 мг/л).</p></sec><sec><title>Заключение</title><p>Заключение. Полученные нами результаты свидетельствуют о отсутствии эффективности представленного плана санаторно-курортного лечения в коррекции НИВ, а также о необходимости более глубоких научных изысканий в направлении изучения механизмов формирования НИВ и методов борьбы с данным состоянием.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. Low-grade inflammation is currently one of the main risk factors for the development of adverse events in the cardiovascular system, including death from cardiovascular diseases or their complications that cause mortality in the postCOVID period.</p></sec><sec><title>The aim of the study</title><p>The aim of the study. To assess the impact of health resort treatment in the conditions of the Southern Coast of Crimea on clinical and functional parameters, as well as on the level of systemic inflammation in patients after a new coronavirus infection.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study included 67 patients (54.9 ± 9.05 years) in the post-COVID period who underwent health resort treatment at the I.M. Sechenov Academic Research Institute of Physical Treatment Methods, Medical Climatology and Rehabilitation. Methods of health resort treatment included climatic treatment on the Southern Coast of Crimea, therapeutic breathing exercises, terrainkur, and various methods of respiratory therapy. In all patients, the study of the C-reactive protein (CRP) in peripheral blood upon admission and at discharge was carried out.</p></sec><sec><title>Results</title><p>Results. Despite a statistically significant improvement in most clinical and functional parameters, the level of CRP and the number of leukocytes and their subpopulations in peripheral blood in patients who underwent health resort treatment did not differ significantly (p &gt; 0.05) from the baseline values obtained upon admission at the I.M. Sechenov Academic Research Institute of Physical Treatment Methods, Medical Climatology and Rehabilitation. The CRP index upon admission and at discharge corresponded to the lower limit of the interval specific for low-grade inflammation (from 3 to 10 mg/l).</p></sec><sec><title>Conclusion</title><p>Conclusion. Our results indicate the lack of effectiveness of the presented plan of health resort treatment in the correction of low-intensity inflammation, as well as the necessity for deeper scientific research in the direction of studying the mechanisms of low-grade inflammation development and the methods of its management.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>SARS-CoV-2</kwd><kwd>воспаление</kwd><kwd>санаторно-курортное лечение</kwd><kwd>постковид</kwd><kwd>СРБ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>SARS-CoV-2</kwd><kwd>inflammation</kwd><kwd>health resort treatment</kwd><kwd>post-COVID</kwd><kwd>CRP</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено при финансовой поддержке Министерства науки и высшего образования Российской Федерации, программа «Приоритет-2030» № 075- 15-2021-1323.</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">COVID-19 coronavirus pandemic worldometer. 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