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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2023-8.1.18</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-4002</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>СТОМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>STOMATOLOGY</subject></subj-group></article-categories><title-group><article-title>Распространённость зубочелюстных аномалий в условиях продолжительного поступления вариативных концентраций системных фторидов: обзор литературы</article-title><trans-title-group xml:lang="en"><trans-title>Prevalence of malocclusions under conditions of prolonged introduction of systemic fluorides in variable concentrations: Literature review</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7971-633X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беляев</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Belyaev</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Беляев Вадим Владимирович – кандидат медицинских наук, доцент кафедры детской стоматологии и ортодонтии, </p><p>170100, г. Тверь, ул. Советская, 4</p></bio><bio xml:lang="en"><p>Vadim V. Belyaev – Cand. Sc. (Med), Associate Professor at the Department of Pediatric Dentistry and Orthodontics, </p><p>Sovetskaya str. 4, Tver 170100</p></bio><email xlink:type="simple">stombel69@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9227-9173</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гаврилова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gavrilova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гаврилова Ольга Анатольевна – доктор медицинских наук, доцент, заведующая кафедрой детской стоматологии и ортодонтии, </p><p>170100, г. Тверь, ул. Советская, 4</p></bio><bio xml:lang="en"><p>Olga A. Gavrilova – Dr. Sc. (Med.), Docent, Head of the Department of Pediatric Dentistry and Orthodontics,</p><p>Sovetskaya str. 4, Tver 170100</p></bio><email xlink:type="simple">olga.gavrilova2512@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0437-0036</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беляев</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Belyaev</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Беляев Игорь Вадимович – ассистент кафедры детской стоматологии и ортодонтии,</p><p>170100, г. Тверь, ул. Советская, 4</p></bio><bio xml:lang="en"><p>Igor V. Belyaev – Teaching Assistant at the Department of Pediatric Dentistry and Orthodontics, </p><p>Sovetskaya str. 4, Tver 170100</p></bio><email xlink:type="simple">igfrost69@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1778-6615</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мяло</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Myalo</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мяло Ольга Александровна – кандидат медицинских наук, ассистент кафедры детской стоматологии и ортодонтии, </p><p>170100, г. Тверь, ул. Советская, 4</p></bio><bio xml:lang="en"><p>Olga A. Myalo – Cand. Sc. (Med.), Associate Professor at the Department of Pediatric Dentistry and Orthodontics,</p><p>Sovetskaya str. 4, Tver 170100</p></bio><email xlink:type="simple">omyalo@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3057-5609</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Эль-Айди</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>El-Aydi</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Эль-Айди Мустафа Ахмед – ассистент кафедры детской стоматологии и ортодонтии,</p><p>170100, г. Тверь, ул. Советская, 4</p></bio><bio xml:lang="en"><p>Mustafa A. El-Aydi – Teaching Assistant at the Department of Pediatric Dentistry and Orthodontics,</p><p>Sovetskaya str. 4, Tver 170100</p></bio><email xlink:type="simple">annamustafa76@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Тверской государственный медицинский университет» Минздрава России</institution></aff><aff xml:lang="en"><institution>Tver State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>12</day><month>03</month><year>2023</year></pub-date><volume>8</volume><issue>1</issue><fpage>158</fpage><lpage>169</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Беляев В.В., Гаврилова О.А., Беляев И.В., Мяло О.А., Эль-Айди М.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Беляев В.В., Гаврилова О.А., Беляев И.В., Мяло О.А., Эль-Айди М.А.</copyright-holder><copyright-holder xml:lang="en">Belyaev V.V., Gavrilova O.A., Belyaev I.V., Myalo O.A., El-Aydi M.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/4002">https://www.actabiomedica.ru/jour/article/view/4002</self-uri><abstract><p>Патогенез нарушений прикуса, широко распространённых среди населения всех стран, хорошо представлен в специальной литературе. Возникновение зубочелюстных аномалий связывают с генетическими и разнообразными факторами окружающей среды. Среди последних особый интерес представляют фториды, оказывающие влияние на распространённость ряда стоматологических заболеваний. Однако публикации, отражающие частоту малокклюзий среди населения в регионах с различным уровнем фторидов в питьевой воде, малочисленны. Данная проблема представляется значимой в условиях возрастающего воздействия соединений фтора на здоровье, в том числе стоматологическое, человека.</p><p>Целью исследования явился анализ литературы о частоте нарушений окклюзии у населения, проживающего в условиях вариативного содержания фторидов в питьевой воде. Выполнен ручной поиск отечественной и зарубежной литературы в поисковых базах PubMed, Medline, Google Scholar. Из  первоначального списка публикаций для анализа выбраны 18  статей, отвечающих критериям включения в исследование.</p><p>Выявлена значительная вариативность результатов исследований. Одни авторы отмечают более высокую распространённость зубочелюстных аномалий среди населения в условиях повышенного поступления фторидов, другие – меньшую, третьи не выявили различий между значениями, полученными в обеих выборках. Большинство оцениваемых публикаций методологически не соответствовали современным международным стандартам, в связи с чем были малодоказательными.</p><p>Данные литературы не дают оснований для однозначной оценки соединений фтора в качестве средового фактора, опосредованно влияющего на процесс формирования окклюзии у человека и животных.</p><p>Обзор не позволил сделать окончательного заключения о вероятном влиянии системных фторидов на распространённость и структуру малокклюзии у человека и животных. Требуется выполнение исследований, соответствующих принципам доказательной медицины. </p></abstract><trans-abstract xml:lang="en"><p>The pathogenesis of malocclusions, which are common among the population of  all  countries, is  well represented in the professional literature. The occurrence of  malocclusions is associated with genetic and various environmental factors. Among the latter, fluorides which affect the prevalence of some dental diseases are of particular interest. However, there are few publications reflecting the frequency of malocclusion among the population in the regions with different levels of fluoride in drinking water. This problem seems to be significant in the context of the increasing impact of fluorine compounds on human health, including dental health.</p><p>The aim of the study. To analyze the literature on the frequency of malocclusion among the population living in conditions of variable fluoride content in drinking water. A manual search of domestic and foreign literature was performed in the search databases PubMed, Medline and Google Scholar. From the initial list of publications, eighteen articles that met the inclusion criteria for the study were selected for analysis. We revealed significant variability of the research results. Some authors note a higher prevalence of malocclusions among the population under conditions of increased fluoride intake, others note a lower one, and still others did not reveal any differences between the values obtained in both samples. Most of the assessed publications did not methodologically meet modern international standards, and therefore were of little evidence.</p><p>The literature data do not provide grounds for an unambiguous assessment of fluorine compounds as an environmental factor that indirectly affects the process of occlusion formation in humans and animals.</p><p>The review did not allow to make a definitive conclusion on the possible impact of  systemic fluorides on the prevalence and pattern of malocclusion in humans and animals. It requires the implementation of studies that comply with the principles of evidence-based medicine. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>зубочелюстные аномалии</kwd><kwd>фториды</kwd><kwd>питьевая вода</kwd><kwd>зубы</kwd><kwd>кость</kwd><kwd>прорезывание зубов</kwd><kwd>размеры зубов</kwd></kwd-group><kwd-group xml:lang="en"><kwd>malocclusion</kwd><kwd>fluorides</kwd><kwd>drinking water</kwd><kwd>teeth</kwd><kwd>bone</kwd><kwd>teething</kwd><kwd>tooth size</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Alhammadi MS, Halboub E, Fayed MS, Labib A, El-Saaidi C. Global distribution of malocclusion traits: A systematic review. Dental Press J Orthod. 2018; 23(6): 40e10. doi: 10.1590/2177-6709.23.6.40.e1-10.onl</mixed-citation><mixed-citation xml:lang="en">Alhammadi MS, Halboub E, Fayed MS, Labib A, El-Saaidi C. 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