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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2023-8.1.8</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-3989</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИНФЕКЦИОННЫЕ БОЛЕЗНИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INFECTIOUS DISEASES</subject></subj-group></article-categories><title-group><article-title>Оценка психоэмоционального состояния пациентов, перенёсших COVID-19-ассоциированную пневмонию, во взаимосвязи с лабораторными показателями</article-title><trans-title-group xml:lang="en"><trans-title>Assessment of the psycho-emotional state of patients after COVID-19-associated pneumonia in relationship with laboratory indicators</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6251-4179</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петелина</surname><given-names>Т. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Petelina</surname><given-names>T. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Петелина Татьяна Ивановна – доктор медицинских наук, ведущий научный сотрудник научного отделения артериальной гипертонии и коронарной недостаточности научного отдела клинической кардиологии, </p><p>625026, г. Тюмень, ул. Мельникайте, 111</p></bio><bio xml:lang="en"><p>Tatiana I. Petelina – Dr. Sc. (Med.), Leading Research Officer at the Department of Arterial Hypertension and Coronary Insufficiency, Scientific Department of Clinical Cardiology, </p><p>Melnikayte str. 111, Tyumen 625026</p></bio><email xlink:type="simple">petelina@infarkta.net</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8552-1646</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гуськова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Guskova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гуськова Ольга Александровна – медицинский психолог, младший научный сотрудник научного отдела инструментальных методов исследования, </p><p>625026, г. Тюмень, ул. Мельникайте, 111</p></bio><bio xml:lang="en"><p>Olga A. Guskova – Medical Psychologist, Junior Research Officer at the Scientific Department of Instrumental Research Methods, </p><p>Melnikayte str. 111, Tyumen 625026</p></bio><email xlink:type="simple">guskova@infarkta.net</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8280-2028</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мусихина</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Musikhina</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мусихина Наталья Алексеевна – кандидат медицинских наук, заведующая отделением неотложной кардиологии научного отдела клинической кардиологии, </p><p>625026, г. Тюмень, ул. Мельникайте, 111</p></bio><bio xml:lang="en"><p>Natalia A. Musikhina – Cand. Sc. (Med.), Head of the Department of Emergency Cardiology, Scientific Department of Clinical Cardiology,</p><p>Melnikayte str. 111, Tyumen 625026</p></bio><email xlink:type="simple">musikhina@infarkta.net</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2056-2217</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Щербинина</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Shcherbinina</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Щербинина Анастасия Евгеньевна – младший научный сотрудник лаборатории клинико-диагностических и молекулярно-генетических исследований научного отдела клинической кардиологии, </p><p>625026, г. Тюмень, ул. Мельникайте, 111</p></bio><bio xml:lang="en"><p>Anastasiya E. Shcherbinina – Junior Research Officer at the Laboratory of Clinical Diagnostic and Molecular Genetic Studies, Scientific Department of Clinical Cardiology,</p><p>Melnikayte str. 111, Tyumen 625026</p></bio><email xlink:type="simple">ScherbininaAE@infarkta.ne</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9232-5034</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гаранина</surname><given-names>В. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Garanina</surname><given-names>V. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гаранина Валерия Дмитриевна – ординатор, </p><p>625026, г. Тюмень, ул. Мельникайте, 111</p></bio><bio xml:lang="en"><p>Valeriya D. Garanina – Resident, </p><p>Melnikayte str. 111, Tyumen 625026</p></bio><email xlink:type="simple">garanina@infarkta.net</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3620-0659</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гапон</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Gapon</surname><given-names>L. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гапон Людмила Ивановна – доктор медицинских наук, профессор, Заслуженный деятель науки РФ, научный руководитель научного отдела клинической кардиологии, </p><p>625026, г. Тюмень, ул. Мельникайте, 111</p></bio><bio xml:lang="en"><p>Liudmila I. Gapon – Dr. Sc. (Med.), Professor, Head of the Scientific Department of Clinical Cardiology,</p><p>Melnikayte str. 111, Tyumen 625026</p></bio><email xlink:type="simple">gapon@infarkta.net</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1436-8853</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ярославская</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Yaroslavskaya</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ярославская Елена Ильинична – доктор медицинских наук, заведующая отделением ультразвуковой диагностики научного отдела инструментальных методов исследования, </p><p>625026, г. Тюмень, ул. Мельникайте, 111</p></bio><bio xml:lang="en"><p>Elena I. Yaroslavskaya – Dr. Sc. (Med.), Head of the Ultrasound Diagnostics Department, Scientific Department of Instrumental Research Methods,</p><p>Melnikayte str. 111, Tyumen 625026</p></bio><email xlink:type="simple">yaroslavskay@infarkta.net</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Тюменский кардиологический научный центр – филиал ФГБНУ «Томский национальный исследовательский медицинский центр Российской академии наук»</institution></aff><aff xml:lang="en"><institution>Tyumen Cardiology Research Center – Branch of Tomsk National Research Medical Center</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>07</day><month>03</month><year>2023</year></pub-date><volume>8</volume><issue>1</issue><fpage>66</fpage><lpage>78</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Петелина Т.И., Гуськова О.А., Мусихина Н.А., Щербинина А.Е., Гаранина В.Д., Гапон Л.И., Ярославская Е.И., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Петелина Т.И., Гуськова О.А., Мусихина Н.А., Щербинина А.Е., Гаранина В.Д., Гапон Л.И., Ярославская Е.И.</copyright-holder><copyright-holder xml:lang="en">Petelina T.I., Guskova O.A., Musikhina N.A., Shcherbinina A.E., Garanina V.D., Gapon L.I., Yaroslavskaya E.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/3989">https://www.actabiomedica.ru/jour/article/view/3989</self-uri><abstract><sec><title>Цель</title><p>Цель. Исследовать особенности и ассоциацию психологических и лабораторных показателей у пациентов с сердечно-сосудистыми заболеваниями (ССЗ), перенёсших COVID-19-ассоциированную пневмонию, с целью уточнения факторов, влияющих на возможность развития отсроченных психологических и сердечно-сосудистых нежелательных явлений.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. В исследование включены 350 пациентов, сформировано две группы исследования. Первая группа – 92 пациента без ССЗ, вторая – 258 пациентов с ССЗ. Оценивали параметры общего и биохимического анализов крови, психологические показатели по данным анкетирования с использованием скрининговых шкал GAD-7 (General Anxiety Disorder-7 – признаки тревоги), PHQ-9 (Patient Health Questionnaire-9 – признаки депрессии) и ШВС (шкала воспринимаемого стресса – признаки стресса) и опросника качества жизни (SF-36, Short Form  36) во время госпитализации и через 3 месяца после выписки из моногоспиталя.</p></sec><sec><title>Результаты</title><p>Результаты. Через 3 месяца в общей группе пациентов признаки тревоги и депрессии выявлены более чем у 30 % обследованных пациентов, признаки стресса – у 10,4 %. В группе с наличием ССЗ нарушения психоэмоциональной сферы определены у 1/4 больных, а выраженный стресс – у 8  % включённых в исследование. Кроме этого, зарегистрировано, что показатели скорости оседания эритроцитов, фибриногена, высокочувствительного C-реактивного белка (CРБ), гомоцистеина и ИЛ-6 сохранились на  более высоком уровне во второй группе. Корреляционный анализ показал, что психологический компонент здоровья взаимосвязан с уровнем нейтрофилов (p = 0,044) и фибриногена (p = 0,050); физический компонент здоровья взаимосвязан с уровнем эритроцитов (p = 0,030), гемоглобина (p = 0,015), СРБ (p = 0,002), креатинфосфокиназы (p = 0,036) и глюкозы (p = 0,017). Регрессионный анализ выявил, что у пациентов с ССЗ через 3  месяца после госпитализации повышенный показатель глюкозы способствует ухудшению, а повышенные показатели гематокрита и средней концентрации гемоглобина – улучшению качества жизни пациентов.</p></sec><sec><title>Заключение</title><p>Заключение. Лабораторные маркеры, поддерживающие длительность пролонгированной сосудистой реакции, нарушение реологических и метаболических свойств крови, определяют характер развития как психологических, так и сердечно-сосудистых осложнений. </p></sec></abstract><trans-abstract xml:lang="en"><sec><title>The aim</title><p>The aim. To study peculiarities and association of psychological and laboratory indicators in patients with cardiovascular diseases (CVD) who underwent COVID-19 to clarify the factors affecting the possibility of developing delayed psychological and cardiovascular adverse events.</p></sec><sec><title>Methods</title><p>Methods. The study enrolled 350 patients with COVID-19. Group 1 consisted of 92 patients without CVD, Group 2 – of 258 patients with CVD. Indicators of laboratory and psychological parameters were assessed according to the data of psychological questionnaire using GAD-7 (General Anxiety Disorder-7), PHQ-9 (Patient Health Questionnaire-9), PSS (Perceived Stress Scale) screening scales and SF-36. Parameters of complete blood count and biochemical blood tests were measured during hospitalization and three months after discharge from the monohospital.</p></sec><sec><title>Results</title><p>Results. After three months, in the general group of patients, signs of anxiety and depression were detected in more than 30 % of the examined patients, signs of stress – in 10.4 %. In the group with CVD, psycho-emotional disorders were identified in 1/4 of the patients, and severe stress – in 8 % of those included in the study. In addition, it was registered that the indicators of erythrocyte sedimentation rate, fibrinogen, high-sensitivity C-reactive protein (CRP), homocysteine and IL-6 remained at a higher level in the second group.</p><p>Correlation analysis showed that the psychological component of health is interconnected with the level of neutrophils (p = 0.044) and fibrinogen (p = 0.050); the physical component of health is correlated with the level of erythrocytes (p = 0.030), hemoglobin (p = 0.015), CRP (p = 0.002), creatine phosphokinase (p = 0.036) and glucose (p = 0.017). Regression analysis revealed that in patients with CVD three months after hospitalization, an increased glucose index contributes to deterioration, and increased hematocrit and mean hemoglobin concentration improve the quality of life of patients.</p></sec><sec><title>Conclusion</title><p>Conclusion. Laboratory markers that maintain the duration of a prolonged vascular reaction, violation of the rheological and metabolic properties of blood, determine the nature of the development of both psychological and cardiovascular complications.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>психологический статус</kwd><kwd>биомаркеры</kwd><kwd>сердечно-сосудистые заболевания</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>biomarkers</kwd><kwd>psychological status</kwd><kwd>cardiovascular disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Костина О.В., Галова Е.А., Любавина Н.А., Преснякова М.В., Ведунова М.В. Характеристика изменений биохимических показателей при динамическом наблюдении у пациентов с СОVID-19 и в постковидном периоде. 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