The modern model of infusion pharmacotherapy in hospitals involves a process-based approach, the most important "input" of which is the manufacturing of infusion admixtures and the control of infusions preparation. In Russian hospitals, production of drug admixtures is carried out by nursing staff in inappropriate conditions and with equipment unappropriated for this type of activity. In accordance with the normative documentation, manufacturing of infusion admixtures should be reserved for hospital pharmacies. Only in pharmacies it is possible to organize a manufacture complex of infusion admixtures of adequate quality under aseptic conditions. For the extemporaneous manufacturing of infusion admixtures in hospital pharmacies of the Russian Federation we have developed technological complex, which included: development of information database "Interaction of injectable drugs"; development of technological schemes of manufacturing of infusion mixtures; selection of necessary equipment; development of a system of quality control of infusion admixtures. The information database is a search engine that allows to estimate the composition of the recipe on the compatibility of components. The typical scheme of production areas of hospital pharmacy allows you to place required for aseptic manufacturing equipment with minimal costs. Step by step instruction on mixing the components of the recipe eliminates contamination in product. The system of quality control confirms the high quality of infusion admixtures. Overall, this technological complex ensures quality, efficiency and safety provided to patients of the hospital infusion therapy.