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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2022-7.6.7</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-3883</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИНФЕКЦИОННЫЕ БОЛЕЗНИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INFECTIOUS DISEASES</subject></subj-group></article-categories><title-group><article-title>Когнитивные и эмоциональные нарушения, ассоциированные с COVID-19 (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Cognitive and emotional impairments associated with COVID-19 (literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6243-9391</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поляков</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Polyakov</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Поляков Владимир Матвеевич – доктор биологических наук, руководитель лаборатории психонейросоматической патологии детского возраста </p><p>664003, г. Иркутск, ул. Тимирязева, 16, Россия</p></bio><bio xml:lang="en"><p>Vladimir M. Polyakov – Dr. Sc. (Biol.), Head of the Laboratory of Pediatric Psychoneurosomatic Pathology</p><p>Timiryazevа str. 16, Irkutsk 664003, Russian Federation </p></bio><email xlink:type="simple">vmpolyakov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5328-8525</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черевикова</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Cherevikova</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черевикова Ирина Александровна – младший научный сотрудник лаборатории психонейросоматических патологий детского возраста </p><p>664003, г. Иркутск, ул. Тимирязева, 16, Россия</p></bio><bio xml:lang="en"><p>Irina A. Cherevikova – Junior Research Officer at the Laboratory of Pediatric Psychoneurosomatic Pathology</p><p>Timiryazevа str. 16, Irkutsk 664003, Russian Federation </p></bio><email xlink:type="simple">gothic.craze@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8451-9341</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мясищев</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Myasishchev</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мясищев Николай Анатольевич – лаборант-исследователь лаборатории психонейросоматических патологий детского возраста </p><p>664003, г. Иркутск, ул. Тимирязева, 16, Россия</p></bio><bio xml:lang="en"><p>Nikolai A. Myasishchev – Assistant Researcher at the Laboratory of Pediatric Psychoneurosomatic Pathology </p><p>Timiryazevа str. 16, Irkutsk 664003, Russian Federation </p></bio><email xlink:type="simple">roulih@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2910-0737</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рычкова</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rychkova</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рычкова Любовь Владимировна – доктор медицинских наук, профессор, член-корреспондент РАН, директор </p><p>664003, г. Иркутск, ул. Тимирязева, 16, Россия</p></bio><bio xml:lang="en"><p>Lyubov V. Rychkova – Dr. Sc. (Med.), Professor, Corresponding Member of RAS, Director </p><p>Timiryazevа str. 16, Irkutsk 664003, Russian Federation </p></bio><email xlink:type="simple">rychkova.nc@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4832-3875</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Косовцева</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosovtseva</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Косовцева Арюна Сергеевна – кандидат биологических наук, научный сотрудник лаборатории психонейросоматических патологий детского возраста </p><p>664003, г. Иркутск, ул. Тимирязева, 16, Россия</p></bio><bio xml:lang="en"><p>Aryuna S. Kosovtseva – Cand. Sc. (Med.), Research Officer at the Laboratory of Pediatric Psychoneurosomatic Pathology </p><p>Timiryazevа str. 16, Irkutsk 664003, Russian Federation </p></bio><email xlink:type="simple">arjuna6402@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0361-2868</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вотинева</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Votineva</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вотинева Анастасия Сергеевна – младший научный сотрудник лаборатории психонейросоматических патологий детского возраста </p><p>664003, г. Иркутск, ул. Тимирязева, 16, Россия</p></bio><bio xml:lang="en"><p>Anastasiya S. Votineva – Junior Research Officer at the Laboratory of Pediatric Psychoneurosomatic Pathology </p><p>Timiryazevа str. 16, Irkutsk 664003, Russian Federation </p></bio><email xlink:type="simple">adomashenkina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8236-1747</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Прохорова</surname><given-names>Ж. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Prokhorova</surname><given-names>Zh. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Прохорова Жанна Владимировна – кандидат биологических наук, медицинский психолог, заведующая кабинетом медицинской психологии и психотерапии клиники </p><p>664003, г. Иркутск, ул. Тимирязева, 16, Россия</p></bio><bio xml:lang="en"><p>Zhanna V. Prokhorova – Cand. Sc. (Med.), Medical Psychologist, Head of the Office of Medical Psychology and Psychotherapy </p><p>Timiryazevа str. 16, Irkutsk 664003, Russian Federation </p></bio><email xlink:type="simple">proxorowa.janna2011@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2124-6328</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колесников</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolesnikov</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Колесников Сергей Иванович – доктор медицинских наук, профессор, академик РАН, советник РАН </p><p>664003, г. Иркутск, ул. Тимирязева, 16, Россия</p></bio><bio xml:lang="en"><p>Sergey I. Kolesnikov – Dr. Sc. (Med.), Professor, Academician of RAS, Counselor of RAS </p><p>Timiryazevа str. 16, Irkutsk 664003, Russian Federation </p></bio><email xlink:type="simple">sikolesnikov2012@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научный центр проблем здоровья, семьи и репродукции человека»</institution></aff><aff xml:lang="en"><institution>Scientific Centre for Family Health and Human Reproduction Problems</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>29</day><month>12</month><year>2022</year></pub-date><volume>7</volume><issue>6</issue><fpage>71</fpage><lpage>81</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Поляков В.М., Черевикова И.А., Мясищев Н.А., Рычкова Л.В., Косовцева А.С., Вотинева А.С., Прохорова Ж.В., Колесников С.И., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Поляков В.М., Черевикова И.А., Мясищев Н.А., Рычкова Л.В., Косовцева А.С., Вотинева А.С., Прохорова Ж.В., Колесников С.И.</copyright-holder><copyright-holder xml:lang="en">Polyakov V.M., Cherevikova I.A., Myasishchev N.A., Rychkova L.V., Kosovtseva A.S., Votineva A.S., Prokhorova Z.V., Kolesnikov S.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/3883">https://www.actabiomedica.ru/jour/article/view/3883</self-uri><abstract><p>Обоснование. В настоящее время выделяют два основных направления изучения влияния новой коронавирусной инфекции на психические процессы: первое – в связи с режимом самоизоляции и ограничений в условиях пандемии; второе – с воздействием самого патологического процесса и постковидного синдрома на центральную нервную систему (ЦНС). Результаты исследований указывают на взаимосвязь данной инфекции с локальными поражениями головного мозга и соответствующими нарушениями работы психических процессов.Целью данной статьи явилась систематизация и анализ результатов исследований, посвящённых основным путям проникновения вируса SARSCoV-2 в ЦНС, когнитивным и эмоциональным нарушениям у лиц, переболевших COVID-19, и обсуждению направлений психологической реабилитации данной группы пациентов.Материалы и методы. Информационный поиск проводился с использованием интернет-ресурсов (PubMed, Web of Science, Scopus, bmj.com, eLibrary. ru, frontiersin.org, sciencedirect.com, ncbi.nlm.nih.gov), анализировались литературные источники за период с мая 2020 г. по ноябрь 2021 г. по следующим ключевым словам: COVID-19, SARS-CoV-2, когнитивные функции (cognitive functions, cognitions), когнитивные нарушения (cognitive impairments), эмоциональные нарушения (emotional dysfunction), аффективные нарушения (affective dysfunction).Результаты.Согласно анализу литературы, большинство исследователей выделяют нейрогенный путь проникновения SARS-CoV-2 в ЦНС, а также проникновение через кровоток или посредством церебрального лимфодренажа, являющиеся возможной причиной возникновения психических нарушений неврологической природы. Коррекция данных нарушений предполагает создание комплексной системы реабилитации с включением психотерапевтических методов.Заключение. Несмотря на отсутствие единой картины, описывающей специфику когнитивной и аффективной симптоматики при COVID-19, в самых общих чертах существует определённый консенсус. Так, довольно часто постковидную когнитивную симптоматику характеризуют нарушениями памяти и внимания, а постковидную аффективную – повышенным уровнем тревожности, депрессии и утомляемости. Вопросы диагностики и коррекции нарушений при постковидном синдроме и допустимость существования данного диагноза по-прежнему актуальны.</p></abstract><trans-abstract xml:lang="en"><p>Background. Currently, there are two main areas of study of the impact of a new coronavirus infection on mental processes: the first is in connection with the regime of self-isolation and restrictions in a pandemic; the second – with the impact of the pathological process itself and the post-covid syndrome on the central nervous system. The results of the studies indicate the relationship of this infection with local lesions of the brain and the corresponding disturbances in the functioning of mental processes.The aim of the research. To systematize and analyze the results of studies on the main routes of penetration of the SARS-CoV-2 virus into the central nervous system, cognitive and emotional disorders in people who have recovered from COVID-19, and to discuss the areas of psychological rehabilitation for this group of patients.Materials and methods. Information search was carried out using Internet resources (PubMed, Web of Science, Scopus, bmj.com, eLibrary.ru, frontiersin.org, sciencedirect. com, ncbi.nlm.nih.gov), literature sources were analyzed for the period from May of 2020 to November of 2021 for the following keywords: COVID-19, SARS-CoV-2, cognitive functions, cognitions, cognitive impairments, emotional dysfunction, affective dysfunction.Results. According to the analysis of the literature, most researchers identify the neurogenic pathway of SARS-CoV-2 penetration into the CNS, as well as penetration through the bloodstream or through cerebral lymphatic drainage, which are a possible cause of mental disorders of a neurological nature. Correction of these violations involves the creation of a comprehensive system of rehabilitation with the inclusion of psychotherapeutic methods.Conclusions. Despite the lack of a single picture describing the specifics of cognitive and affective symptoms in COVID-19, in the most general terms, there is a certain consensus. So, quite often, post-COVID cognitive symptoms are characterized by impaired memory and attention, and post-COVID affective symptoms are characterized by increased levels of anxiety, depression, and fatigue. The issues of diagnosis and correction of disorders in post-COVID syndrome and the admissibility of the existence of this diagnosis are still relevant.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>COVID-19</kwd><kwd>постковидный синдром</kwd><kwd>SARS-CoV-2</kwd><kwd>когнитивные нарушения</kwd><kwd>эмоциональные нарушения</kwd><kwd>головной мозг</kwd><kwd>реабилитация</kwd></kwd-group><kwd-group xml:lang="en"><kwd>COVID-19</kwd><kwd>SARS-CoV-2</kwd><kwd>cognitive impairments</kwd><kwd>affective dysfunction</kwd><kwd>brain</kwd><kwd>rehabilitation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Alnefeesi Y, Siegel A, Lui LMW, Teopiz KM, Ho RCM, Lee Y, et al. Impact of SARS-CoV-2 infection on cognitive function: A systematic review. 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