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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2022-7.5-2.15</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-3834</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОФТАЛЬМОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OPHTHALMOLOGY</subject></subj-group></article-categories><title-group><article-title>Возможности применения роговичных лентикул в хирургии заболеваний роговицы (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Possible use of corneal lenticule in surgery of corneal diseases (literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7413-7478</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бойко</surname><given-names>Э. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Boiko</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бойко Эрнест Витальевич – доктор медицинских наук, профессор, директор; заведующий кафедрой офтальмологии; член-корреспондент</p><p>192283, г. Санкт-Петербург, ул. Ярослава Гашека, 21</p><p>191015, г. Санкт-Петербург, ул. Кирочная, 41</p><p>194044, г. Санкт-Петербург, ул. Академика Лебедева, 6</p></bio><bio xml:lang="en"><p>Ernest V. Boiko – Dr. Sc. (Med.), Professor, Director; Head of the Ophthalmology Department; Correspondent Member</p><p>Yaroslava Gasheka str. 21, Saint Petersburg 192283</p><p>Kirochnaya str. 41, Saint Petersburg 191015</p><p>Akademika Lebedeva str. 6, Saint Petersburg 194044</p></bio><email xlink:type="simple">pochta@mntk.spb.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6847-4737</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Титов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Titov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Титов Алексей Валерьевич – заведующий отделением рефракционной хирургии и патологии роговицы, руководитель Глазного Тканевого Банка</p><p>192283, г. Санкт-Петербург, ул. Ярослава Гашека, 21</p></bio><bio xml:lang="en"><p>Aleksei V. Titov – Head of Refractive Surgery and Corneal Pathology Department, Director of the Eye Tissue Bank</p><p>Yaroslava Gasheka str. 21, Saint Petersburg 192283</p></bio><email xlink:type="simple">mr.titov@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6262-1553</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Масян</surname><given-names>Я. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Masian</surname><given-names>J. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Масян Янек Иванович – врач-офтальмолог отделения рефракционной хирургии и патологии роговицы</p><p>192283, г. Санкт-Петербург, ул. Ярослава Гашека, 21</p></bio><bio xml:lang="en"><p>Janek I. Masian – Ophthalmologist at the Refractive Surgery and Corneal Pathology Department</p><p>Yaroslava Gasheka str. 21, Saint Petersburg 192283</p></bio><email xlink:type="simple">yanick.masian@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8825-312X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мирсаитова</surname><given-names>Д. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Mirsaitova</surname><given-names>D. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мирсаитова Дилара Равилевна – врач-офтальмолог отделения рефракционной хирургии и патологии роговицы</p><p>192283, г. Санкт-Петербург, ул. Ярослава Гашека, 21</p></bio><bio xml:lang="en"><p>Dilara R. Mirsaitova – Ophthalmologist at the Refractive Surgery and Corneal Pathology Department</p><p>Yaroslava Gasheka str. 21, Saint Petersburg 192283</p></bio><email xlink:type="simple">dilara_mirsaitova@rambler.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Санкт-Петербургский филиал ФГАУ «НМИЦ «МНТК «Микрохирургия глаза» имени академика С.Н. Фёдорова» Минздрава России; ФГБОУ ВО «Северо-Западный государственный медицинский университет имени И.И. Мечникова» Минздрава России; ФГБВОУ ВО «Военно-медицинская академия имени С.М. Кирова» Минобороны России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg Branch of S. Fyodorov Eye Microsurgery Federal State Institution; North-Western State Medical University named after I.I. Mechnikov; S.M. Kirov Military Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Санкт-Петербургский филиал ФГАУ «НМИЦ «МНТК «Микрохирургия глаза» имени академика С.Н. Фёдорова»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg Branch of S. Fyodorov Eye Microsurgery Federal State Institution</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Санкт-Петербургский филиал ФГАУ «НМИЦ «МНТК «Микрохирургия глаза» имени академика С.Н. Фёдорова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg Branch of S. Fyodorov Eye Microsurgery Federal State Institution</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>10</day><month>12</month><year>2022</year></pub-date><volume>7</volume><issue>5-2</issue><fpage>143</fpage><lpage>152</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бойко Э.В., Титов А.В., Масян Я.И., Мирсаитова Д.Р., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Бойко Э.В., Титов А.В., Масян Я.И., Мирсаитова Д.Р.</copyright-holder><copyright-holder xml:lang="en">Boiko E.V., Titov A.V., Masian J.I., Mirsaitova D.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/3834">https://www.actabiomedica.ru/jour/article/view/3834</self-uri><abstract><p>В данном обзоре мы провели анализ отечественной и иностранной литературы по использованию роговичной лентикулы, полученной путём кeраторeфракционной хирургии по технологии SMILE (SMаll Inсision Lеnticula Extraсtion). Активно ведутся исследования по применению лентикулы в рефракционных целях: для коррекции гиперметропии (LIKE – Lenticular Intrastromal Keratoplasty), для коррекции пресбиопии (PEARL – PrEsbyopic Allogenic Refractive Lenticule). Немало работ посвящено использованию лентикулярной ткани для лечения кератэктазий различного генеза. Так, ряд авторов для лечения кератоконуса предлагают имплантацию лентикулы в сформированный фемтолазером роговичный карман реципиента (SLAK – Stromal lenticule addition keratoplasty). Описаны клинические случаи комбинированного лечения: имплантации лентикулы и роговичных интрастромальных сегментов для лечения пеллюцидной дегенерации роговицы. Большое количество работ посвящено применению лентикул для тектонического покрытия язвенных дефектов, краевых истончений при язве Мурена. Описаны отдельные клинические случаи использования роговичной лентикулы для покрытия выраженного роговичного дефекта при рецидивирующем птеригиуме. В данный обзор также были включены статьи, посвящённые проблемам хранения и децеллюляризации роговичных лентикул. Проанализированные статьи показывают широкую область применения роговичной лентикулы, тем не менее требуется больше исследований в каждой из сфер применения, также необходимо решить проблему заготовки и хранения лентикулярной ткани.</p></abstract><trans-abstract xml:lang="en"><p>In this review, we analyzed the domestic and foreign literature on the use of corneal lenticula obtained by keratorefractive surgery using the SMILE technology (SMall Incision Lenticula Extraction). Research is being actively carried out on the use of a lenticular tissue for refractive purposes: for the correction of hyperopia (LIKE – Lenticular Intrastromal Keratoplasty), for the correction of presbyopia (PEARL – PrEsbyopic Allogenic Refractive Lenticule). A significant amount of works are devoted to the use of lenticular tissue for the treatment of keratectasias of various origins. For example, a number of authors for the treatment of keratoconus suggest implantation of a lenticule into the recipient’s corneal pocket formed by a femtolaser (SLAK – Stromal lenticule addition keratoplasty). Clinical cases of combined treatment are described: implantation of a lenticule and corneal intrastromal segments for the treatment of corneal pellucid degeneration. A large number of works are devoted to the use of lenticules for tectonic coverage of ulcerative defects, marginal thinning in Mooren’s ulcer. Several clinical cases of the use of a corneal lenticule to cover a deep corneal defect in recurrent pterygium are described. This review also included articles on the storage and decellularization of corneal lenticules. The analyzed articles show a wide area of application of the corneal lenticule; however, more research is required in each of the areas of application, and it is also necessary to solve the problem of procurement and storage of lenticular tissue.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>лентикула</kwd><kwd>ReLEx SMILE</kwd><kwd>кератоконус</kwd><kwd>пеллюцидная дегенерация</kwd><kwd>интрастромальная кератопластика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>lenticule</kwd><kwd>ReLEx SMILE</kwd><kwd>keratoconus</kwd><kwd>pellucidal corneal degeneration</kwd><kwd>intrastromal keratoplasty</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Mathews PM, Lindsley K, Aldave AJ, Akpek EK. Etiology of global corneal blindness and current practices of corneal transplantation: A focused review. 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