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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2022-7.5-1.5</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-3799</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКУШЕРСТВО И ГИНЕКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>OBSTETRICS AND GYNAECOLOGY</subject></subj-group></article-categories><title-group><article-title>Нарушения обоняния и вкуса у беременных, больных COVID-19</article-title><trans-title-group xml:lang="en"><trans-title>Smell and taste disorders in pregnant women with COVID-19</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4832-3875</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Косовцева</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosovtseva</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Косовцева Арюна Сергеевна – кандидат биологических наук, научный сотрудник лаборатории психонейросоматической патологии детского возраста</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Ariuna S. Kosovtseva – Cand. Sc. (Med.), Research Officer at the Laboratory of Psychoneurosomatic Pediatric Pathology</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">arjuna6402@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3704-830X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баирова</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bairova</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баирова Татьяна Ананьевна – доктор медицинских наук, заведующая лабораторией персонализированной медицины</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Tatyana A. Bairova – Dr. Sc. (Med.), Head of the Laboratory of Personalized Medicine</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">tbairova38@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2910-0737</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рычкова</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rychkova</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рычкова Любовь Владимировна – доктор медицинских наук, профессор, член-корреспондент РАН, директор</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Lyubov V. Rychkova – Dr. Sc. (Med.), Professor, Corresponding Member of RAS, Director</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">iphr@sbamsr.irk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2169-0242</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Орлова Елизавета Андреевна – младший научный сотрудник лаборатории эпидемиологически и социально значимых инфекций</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Elizaveta A. Orlova – Junior Research Officer at the Laboratory of Epidemiologically and Socially Significant Infections</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">elizaveta.a.orlova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8441-3640</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хаснатинов</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Khasnatinov</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Хаснатинов Максим Анатольевич – доктор биологических наук, ведущий научный сотрудник лаборатории трансмиссивных инфекций</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Maxim A. Khasnatinov – Dr. Sc. (Biol.), Leading Research Officer at the Laboratory of Vector-Borne Infections</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">khasnatinov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6705-3073</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Данчинова</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Danchinova</surname><given-names>G. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Данчинова Галина Анатольевна – доктор биологических наук, заведующая лабораторией трансмиссивных инфекций</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Galina A. Danchinova – Dr. Sc. (Biol.), Head of the Laboratory of Vector-Borne Infections</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">dan-chin@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4854-3277</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Михалевич</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Mikhalevich</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Михалевич Исай Моисеевич – кандидат геолого-минералогических наук, инженер группы сопровождения информационных систем</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Isaj M. Mikhalevich – Cand. Sc. (Geol. Mineral.), Engineer at the Information Systems Support Group</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">mim977@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6243-9391</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поляков</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Polyakov</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Поляков Владимир Матвеевич – доктор биологических наук, заведующий лабораторией психонейросоматической патологии детского возраста</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Vladimir M. Polyakov – Dr. Sc. (Biol.), Head of the Laboratory of Psychoneurosomatic Pediatric Pathology</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">vmpolyakov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5328-8525</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черевикова</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Cherevikova</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черевикова Ирина Александровна – младший научный сотрудник лаборатории психонейросоматической патологии детского возраста</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Irina A. Cherevikova – Junior Research Officer at the Laboratory of Psychoneurosomatic Pediatric Pathology</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">gothic.craze@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8451-9341</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мясищев</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Myasishchev</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мясищев Николай Анатольевич – лаборант-исследователь лаборатории психонейросоматических патологий детского возраста</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Nikolay A. Myasishchev – Research Assistant at the Laboratory of Psychoneurosomatic Pediatric Pathology</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">roulih@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8236-1747</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Прохорова</surname><given-names>Ж. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Prokhorova</surname><given-names>Zh. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Прохорова Жанна Владимировна – кандидат биологических наук, научный сотрудник лаборатории психонейросоматической патологии детского возраста</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Zhanna V. Prokhorova – Cand. Sci. (Biol.), Research Officer at the Laboratory of Psychoneurosomatic Pediatric Pathology</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">proxorowa.janna2011@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3354-2992</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колесникова</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolesnikova</surname><given-names>L. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Колесникова Любовь Ильинична – доктор биологических наук, профессор, академик РАН, научный руководитель</p><p>664003, г. Иркутск, ул. Тимирязева, 16</p></bio><bio xml:lang="en"><p>Lyubov I. Kolesnikova – Dr. Sc. (Med.), Professor, Academician of RAS, Academic Director</p><p>Timiryazeva str. 16, Irkutsk 664003</p></bio><email xlink:type="simple">iphr@sbamsr.irk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научный центр проблем здоровья семьи и репродукции человека»</institution></aff><aff xml:lang="en"><institution>Scientific Сentre for Family Health and Human Reproduction Problems</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>06</day><month>12</month><year>2022</year></pub-date><volume>7</volume><issue>5-1</issue><fpage>35</fpage><lpage>45</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Косовцева А.С., Баирова Т.А., Рычкова Л.В., Орлова Е.А., Хаснатинов М.А., Данчинова Г.А., Михалевич И.М., Поляков В.М., Черевикова И.А., Мясищев Н.А., Прохорова Ж.В., Колесникова Л.И., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Косовцева А.С., Баирова Т.А., Рычкова Л.В., Орлова Е.А., Хаснатинов М.А., Данчинова Г.А., Михалевич И.М., Поляков В.М., Черевикова И.А., Мясищев Н.А., Прохорова Ж.В., Колесникова Л.И.</copyright-holder><copyright-holder xml:lang="en">Kosovtseva A.S., Bairova T.A., Rychkova L.V., Orlova E.A., Khasnatinov M.A., Danchinova G.A., Mikhalevich I.M., Polyakov V.M., Cherevikova I.A., Myasishchev N.A., Prokhorova Z.V., Kolesnikova L.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/3799">https://www.actabiomedica.ru/jour/article/view/3799</self-uri><abstract><p>   Обоснование. Нарушение обоняния является признанным клиническим симптомом инфицирования COVID-19. Нерешённым остаётся вопрос потери обоняния в структуре патогенеза COVID-19 при беременности.   Цель исследования. Определить обоняние и вкус у беременных, больных COVID-19, а также оценить взаимосвязь обоняния и количество геном-эквивалентов SARS-CoV-2 в носоглоточном секрете.   Материал и методы. В проведённом исследовании «случай-контроль»участвовала 121 беременная: из них 40 – с новой коронавирусной инфекцией COVID-19, 81 – не болевшая COVID-19 ранее и на момент исследования. Обследование проведено в июле 2021 г. Обоняние оценивали с помощью обонятельного теста Коннектикутского центра хемосенсорных клинических исследований (CCCRC), который включает определение обонятельного порога и оценку идентификации запаха. Вкус измеряли по методике О. Массарелли. Вирусную нагрузку рассчитывали с помощью стандартизованного метода определения количества РНК-копий SARS-CoV-2 в 1 мл носоглоточного секрета.   Результаты. Частота нарушений обоняния (умеренной / тяжёлой степени и аносмии) у беременных с COVID-19 составляет 62,5 % по сравнению с 22,23 % среди беременных, никогда не болевших COVID-19 (р = 0,002). Значимых нарушений вкуса не выявлено. Пороговое значение для манифестации обонятельных нарушений составило 17794 РНК-копий вируса SARS-CoV-2, что соответствует 37-му пороговому циклу (Ct).   Заключение. При беременности в острой фазе COVID-19 значимо нарушается обоняние, но не вкус. Снижение обоняния ассоциировано с вирусной нагрузкой SARS-CoV-2.</p></abstract><trans-abstract xml:lang="en"><p>   Background. Smell disorder is a recognized clinical symptom of COVID-19 infection. The problem of the loss of sense of smell in the structure of COVID-19 pathogenesis during pregnancy remains unresolved.   The aim of the study. To determine the sense of smell and taste in pregnant women with COVID-19, as well as to evaluate the relationship between the sense of smell and the number of SARS-CoV-2 genome equivalents in the nasopharyngeal secretion.   Material and methods. In the case-control study, 121 pregnant women participated: 40 of them were infected with COVID-19; 81 were not infected with COVID-19 earlier and at the time of the study. The survey was conducted in July 2021. Sense of smell was assessed using the Connecticut Chemosensory Clinical Research Center (CCCRC) olfactory test, which includes olfactory threshold determination and odor identification assessment. Taste was measured according to the O. Massarelli method. Viral load was calculated using a standardized method for determining the numberof SARS-CoV-2 RNA copies in 1 ml of nasopharyngeal secretion.   Results. The incidence of olfactory disorders (moderate / severe and anosmia) in pregnant women with COVID-19 is 62.5 % compared to 22.23 % among pregnant women who have never had COVID-19 (p = 0.002). No significant taste disorders were identified. The threshold value for the manifestation of olfactory disorders was 17794 RNA copies of the SARS-CoV-2 virus, which corresponds to the 37th threshold cycle (Ct).   Conclusion. During pregnancy in the acute phase of COVID-19, sense of smell is significantly impaired, but not sense of taste. Decreased sense of smell is associated with SARS-CoV-2 viral load.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>беременные</kwd><kwd>COVID-19</kwd><kwd>обоняние</kwd><kwd>вкус</kwd><kwd>SARS-CoV-2</kwd><kwd>вирусная нагрузка</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pregnant women</kwd><kwd>COVID-19</kwd><kwd>sense of smell</kwd><kwd>taste</kwd><kwd>SARS-CoV-2</kwd><kwd>viral load</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено в рамках инициативного пилотного проекта. Авторы заявляют об отсутствии финансирования. Статья опубликована в рамках V Всероссийской научно-практической конференции молодых учёных с международным участием «Фундаментальные и прикладные аспекты в медицине и биологии»</funding-statement><funding-statement xml:lang="en">The study was carried out as part of an initiative pilot project. The authors claim a lack of funding.The article was published as part of the V All-Russian Scientific and Practical Conference of Young Scientists with international participation "Fundamental and applied aspects in medicine and biology"</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Артымук Н. В. Новая коронавирусная инфекция COVID-19 у беременных Сибири и Дальнего Востока / Н. В. Артымук [и др.] // Вестник интенсивной терапии им. А. И. Салтанова. – 2020. – (2): 41-48.</mixed-citation><mixed-citation xml:lang="en">Artymuk N. V., Belokrinitskaya T. E., Filippov O. S., Shifman E. M. COVID-19 in pregnant women of Siberia and the Far East. Annals of Critical Care. 2020; (2): 41-48. 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