<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2022-7.4.4</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-3642</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ЛЕКЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>LECTURES</subject></subj-group></article-categories><title-group><article-title>Хроническая мошоночная боль: патогенез, клинические фенотипы и современная концепция лечения (клиническая лекция)</article-title><trans-title-group xml:lang="en"><trans-title>Chronic scrotal pain: Pathogenesis, clinical phenotypes and modern treatment concept (clinical lecture)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9278-9739</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лелявин</surname><given-names>К. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Lelyavin</surname><given-names>K. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лелявин Кирилл Борисович – доктор медицинских наук, доцент кафедры скорой медицинской помощи и медицины катастроф</p><p>664049, г. Иркутск, Юбилейный, 100</p></bio><bio xml:lang="en"><p>Kirill B. Lelyavin – Dr. Sc. (Med.), Associate Professor at the Department of Emergency Medicine</p><p>Yubileyniy 100, Irkutsk 664049</p><p> </p></bio><email xlink:type="simple">Lelyavink@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Иркутская государственная медицинская академия последипломного образования – филиал ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России</institution></aff><aff xml:lang="en"><institution>Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>01</day><month>09</month><year>2022</year></pub-date><volume>7</volume><issue>4</issue><fpage>34</fpage><lpage>44</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лелявин К.Б., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Лелявин К.Б.</copyright-holder><copyright-holder xml:lang="en">Lelyavin K.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/3642">https://www.actabiomedica.ru/jour/article/view/3642</self-uri><abstract><p>Хроническая мошоночная боль (ХМБ) – это собирательное понятие, обозначающее множество проблем, вызывающих дискомфорт или боль в мошонке, которые могут быть вызваны проблемами как с яичками, так и с другими структурами органов мошонки: паратестикулярными, придатками яичек, семявыносящими протоками. Для практикующего врача-уролога диагностика и лечение хронической мошоночной боли всегда представляет сложную задачу ввиду многочисленных причин её развития и разнообразия клинических проявлений. ХМБ – распространённое, но при этом малоизученное состояние, этиология которого часто не идентифицируется. Боли, локализующиеся в мошонке, составляют 38,8 % всех случаев хронической тазовой боли у мужчин. С синдромом ХМБ связаны от 2,5 до 4,8 % всех посещений уролога. Первичный мошоночный болевой синдром не ассоциирован с инфекцией или другими локальными патологическими процессами, которые могли служить причиной развития боли. Лечение хронической мошоночной боли представляет собой сложную задачу, поскольку боль часто не поддаётся традиционным методам лечения.</p><p>Цель данной лекции: привлечь внимание урологов, врачей общей практики, а также всех, кому интересна проблема лечения хронической мошоночной боли, к достижениям современной медицины в решении этой сложной мультидисциплинарной проблемы.</p></abstract><trans-abstract xml:lang="en"><p>Chronic scrotal pain (CSP) is a general term, which defines variety of problems causing discomfort or pain in the scrotum, which can be caused by the problems with testicles and other structures of the scrotum: epididymis, vas deferens, paratesticular structures. For a practicing urologist, the diagnosis and treatment of chronic scrotal pain is always a difficult task due to the many reasons for its appearance and the variety of clinical symptoms. CSP is a widespread but poorly understood condition, the etiology of which often can not be identified. Pain localized in the scrotum makes up 38.8 % of all cases of chronic men’s pelvic pain. From 2.5 to 4.8 % of all visits to the urologist relate to CSP syndrome. Primary scrotal pain syndrome is not associated with infection or other local pathological processes that could cause pain. The treatment of chronic scrotal pain is challenging because the pain often does not react to the traditional treatments.</p><p>The purpose of this lecture is to draw the attention of urologists, general practitioners, and everyone who is interested in the problem of treating chronic scrotal pain to the possibilities of modern medicine in solving this multidisciplinary problem.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>боль</kwd><kwd>хроническая боль</kwd><kwd>хроническая мошоночная боль</kwd><kwd>орхиалгия</kwd><kwd>обезболивание</kwd><kwd>мошонка</kwd></kwd-group><kwd-group xml:lang="en"><kwd>pain</kwd><kwd>chronic pain</kwd><kwd>chronic scrotal content pain</kwd><kwd>orchialgia</kwd><kwd>pain management</kwd><kwd>scrotumF</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Campbell K, Lipshultz L. Current trends and therapies in orchialgia management. Ther Adv Urol. 2021; 13: 17562872211026433. doi: 10.1177/17562872211026433</mixed-citation><mixed-citation xml:lang="en">Campbell K, Lipshultz L. Current trends and therapies in orchialgia management. Ther Adv Urol. 2021; 13: 17562872211026433. doi: 10.1177/17562872211026433</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Guidelines of European Association of Urology (EAU), 2021. Presented at the 36th Annual Congress EAU. 2021. URL: http://uroweb.org/guidelines/compilations-of-all-guidelines [date of access: 06.04.2022].</mixed-citation><mixed-citation xml:lang="en">Guidelines of European Association of Urology (EAU), 2021. Presented at the 36th Annual Congress EAU. 2021. URL: http://uroweb.org/guidelines/compilations-of-all-guidelines [date of access: 06.04.2022].</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cirocchi R, Henry BM, Mercurio I, Tomaszewski KA, Palumbo P, Stabile A, et al. Is it possible to identify the inguinal nerves during hernioplasty? A systematic review of the literature and meta-analysis of cadaveric and surgical studies. Hernia. 2019; 23(3): 569-581. doi: 10.1007/s10029-018-1857-2</mixed-citation><mixed-citation xml:lang="en">Cirocchi R, Henry BM, Mercurio I, Tomaszewski KA, Palumbo P, Stabile A, et al. Is it possible to identify the inguinal nerves during hernioplasty? A systematic review of the literature and meta-analysis of cadaveric and surgical studies. Hernia. 2019; 23(3): 569-581. doi: 10.1007/s10029-018-1857-2</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Ayyaz Ul Haq M, Rashid M, Gilchrist IC, Bertrand O, Kwok CS, Wong CW, et al. Incidence and clinical course of limb dysfunction post cardiac catheterization – a systematic review. Circ J. 2018; 82(11): 2736-2744. doi: 10.1253/circj. CJ-18-0389</mixed-citation><mixed-citation xml:lang="en">Ayyaz Ul Haq M, Rashid M, Gilchrist IC, Bertrand O, Kwok CS, Wong CW, et al. Incidence and clinical course of limb dysfunction post cardiac catheterization – a systematic review. Circ J. 2018; 82(11): 2736-2744. doi: 10.1253/circj. CJ-18-0389</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Shoskes DA, Calixte N, Tadros N, Li J, Parekattil S. Validation of the chronic orchialgia symptom index for men with chronic orchialgia/chronic scrotal contents pain. Urology. 2018; 119: 39-43. doi: 10.1016/j.urology.2018.05.030</mixed-citation><mixed-citation xml:lang="en">Shoskes DA, Calixte N, Tadros N, Li J, Parekattil S. Validation of the chronic orchialgia symptom index for men with chronic orchialgia/chronic scrotal contents pain. Urology. 2018; 119: 39-43. doi: 10.1016/j.urology.2018.05.030</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Polackwich AS, Arora HC, Li J, Levine L, Tojuola B, Parekattil S, et al. Development of a clinically relevant symptom index to assess patients with chronic orchialgia/chronic scrotal content pain. Transl Androl Urol. 2018; 7(2): S163-S168. doi: 10.21037/tau.2018.04.10</mixed-citation><mixed-citation xml:lang="en">Polackwich AS, Arora HC, Li J, Levine L, Tojuola B, Parekattil S, et al. Development of a clinically relevant symptom index to assess patients with chronic orchialgia/chronic scrotal content pain. Transl Androl Urol. 2018; 7(2): S163-S168. doi: 10.21037/tau.2018.04.10</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Strebel RT, Leippold T, Luginbuehl T, Muentener M, Praz V, Hauri D. Chronic scrotal pain syndrome: Management among urologists in Switzerland. Eur Urol. 2005; 47: 812-816. doi: 10.1016/j.eururo.2005.01.003</mixed-citation><mixed-citation xml:lang="en">Strebel RT, Leippold T, Luginbuehl T, Muentener M, Praz V, Hauri D. Chronic scrotal pain syndrome: Management among urologists in Switzerland. Eur Urol. 2005; 47: 812-816. doi: 10.1016/j.eururo.2005.01.003</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Christiansen CG, Sandlow JI. Testicular pain following vasectomy: A review of postvasectomy pain syndrome. J Androl. 2003; 24(3): 293-298. doi: 10.1002/j.1939-4640.2003.tb02675.x</mixed-citation><mixed-citation xml:lang="en">Christiansen CG, Sandlow JI. Testicular pain following vasectomy: A review of postvasectomy pain syndrome. J Androl. 2003; 24(3): 293-298. doi: 10.1002/j.1939-4640.2003.tb02675.x</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Quallich SA, Arslanian-Engoren C. Chronic testicular pain in adult men: An integrative literature review. Am J Mens Health. 2013; 7(5): 402-413. doi: 10.1177/1557988313476732</mixed-citation><mixed-citation xml:lang="en">Quallich SA, Arslanian-Engoren C. Chronic testicular pain in adult men: An integrative literature review. Am J Mens Health. 2013; 7(5): 402-413. doi: 10.1177/1557988313476732</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Aljumaily A, Al-Khazraji H, Gordon A, Lau S, Jarvi KA. Characteristics and etiologies of chronic scrotal pain: A common but poorly understood condition. Pain Res Manag. 2017; 2017: 3829168. doi: 10.1155/2017/3829168</mixed-citation><mixed-citation xml:lang="en">Aljumaily A, Al-Khazraji H, Gordon A, Lau S, Jarvi KA. Characteristics and etiologies of chronic scrotal pain: A common but poorly understood condition. Pain Res Manag. 2017; 2017: 3829168. doi: 10.1155/2017/3829168</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Institute of Medicine (US) Committee on Advancing Pain Research, Care, and Education. Relieving pain in America: A blueprint for transforming prevention, care, education, and research. Washington (DC): National Academies Press (US); 2011.</mixed-citation><mixed-citation xml:lang="en">Institute of Medicine (US) Committee on Advancing Pain Research, Care, and Education. Relieving pain in America: A blueprint for transforming prevention, care, education, and research. Washington (DC): National Academies Press (US); 2011.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Parekattil SJ, Ergun O, Gudeloglu A. Management of chronic orchialgia: Challenges and solutions – the current standard of care. Res Rep Urol. 2020; 12: 199-210. doi: 10.2147/RRU.S198785</mixed-citation><mixed-citation xml:lang="en">Parekattil SJ, Ergun O, Gudeloglu A. Management of chronic orchialgia: Challenges and solutions – the current standard of care. Res Rep Urol. 2020; 12: 199-210. doi: 10.2147/RRU.S198785</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Mathias SD, Kuppermann M, Liberman RF, Lipschutz RC, Steege JF. Chronic pelvic pain: prevalence, health-related quality of life, and economic correlates. Obstet Gynecol. 1996; 87(3): 321327. doi: 10.1016/0029-7844(95)00458-0</mixed-citation><mixed-citation xml:lang="en">Mathias SD, Kuppermann M, Liberman RF, Lipschutz RC, Steege JF. Chronic pelvic pain: prevalence, health-related quality of life, and economic correlates. Obstet Gynecol. 1996; 87(3): 321327. doi: 10.1016/0029-7844(95)00458-0</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Hedelin H, Johannisson H,Welin L. Prevalence of the chronic prostatitis/chronic pelvic pain syndrome among 40-69-year-old men residing in a temperate climate. Scand J Urol. 2013; 47(5): 390-392. doi: 10.3109/00365599.2012.756930</mixed-citation><mixed-citation xml:lang="en">Hedelin H, Johannisson H, Welin L. Prevalence of the chronic prostatitis/chronic pelvic pain syndrome among 40-69-year-old men residing in a temperate climate. Scand J Urol. 2013; 47(5): 390-392. doi: 10.3109/00365599.2012.756930</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Zermann DH, Ishigooka M, Doggweiler R, Schmidt RA. Neurourological insights into the etiology of genitourinary pain in men. J Urol. 1999; 161(3): 903-908.</mixed-citation><mixed-citation xml:lang="en">Zermann DH, Ishigooka M, Doggweiler R, Schmidt RA. Neurourological insights into the etiology of genitourinary pain in men. J Urol. 1999; 161(3): 903-908.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Leslie SW, Sajjad H, Siref LE. Chronic testicular pain and orchalgia [Updated 2021 Sep 17]. Treasure Island (FL): StatPearls Publishing; 2022.</mixed-citation><mixed-citation xml:lang="en">Leslie SW, Sajjad H, Siref LE. Chronic testicular pain and orchalgia [Updated 2021 Sep 17]. Treasure Island (FL): StatPearls Publishing; 2022.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Ciftci H, Savas M, Yeni E, Verit A, Topal U. Chronic orchialgia and associated diseases. Current Urology. 2010; 4(2): 67-70. doi: 10.1159/000253415</mixed-citation><mixed-citation xml:lang="en">Ciftci H, Savas M, Yeni E, Verit A, Topal U. Chronic orchialgia and associated diseases. Current Urology. 2010; 4(2): 67-70. doi: 10.1159/000253415</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Корнеев И.А. Невоспалительный синдром хронической тазовой боли (мошоночный болевой синдром) у бесплодного мужчины с не пальпируемой семиномой яичка и билатеральным тестикулярным микролитиазом: случай из практики. Вестник урологии. 2019; 7(3): 55-58. doi: 10.21886/2308-6424-2019-7-3-55-58</mixed-citation><mixed-citation xml:lang="en">Korneyev IA. Non-inflammatory chronic pelvic pain syndrome (scrotal pain) in an infertile man with non-palpable testicular seminoma and bilateral testicular microlithiasis. Case study. Urology Herald. 2019; 7(3): 55-58. (In Russ.) doi: 10.21886/2308-6424-20197-3-55-58</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Luo L, Wu SZ, Zhu C, Fan Q, Liu K, Sun G. Psychological long-term effects of sterilization on anxiety and depression. Contraception. 1996; 54(6): 345-357. doi: 10.1016/s0010-7824(96)00200-4</mixed-citation><mixed-citation xml:lang="en">Luo L, Wu SZ, Zhu C, Fan Q, Liu K, Sun G. Psychological long-term effects of sterilization on anxiety and depression. Contraception. 1996; 54(6): 345-357. doi: 10.1016/s0010-7824(96)00200-4</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Кучер А.Н. Нейрогенное воспаление: биохимические маркеры, генетический контроль и болезни. Бюллетень сибирской медицины. 2020; 19(2): 171-181. doi: 10.20538/16820363-2020-2-171-181</mixed-citation><mixed-citation xml:lang="en">Kucher AN. Neurogenic inflammation: biochemical markers, genetic control and diseases. Bulletin of Siberian Medicine. 2020; 19(2): 171-181. (In Russ.). doi: 10.20538/1682-0363-2020-2-171-181</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Singh V, Sinha RJ. Idiopathic chronic orchialgia – a frustrating issue for the clinician and the patient. Indian J Surg. 2008; 70(3): 107-110. doi: 10.1007/s12262-008-0032-x</mixed-citation><mixed-citation xml:lang="en">Singh V, Sinha RJ. Idiopathic chronic orchialgia – a frustrating issue for the clinician and the patient. Indian J Surg. 2008; 70(3): 107-110. doi: 10.1007/s12262-008-0032-x</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Nassenstein C, Krasteva-Christ G, Renz H. New aspects of neuroinflammation and neuroimmune crosstalk in the airways. J Allergy Clin Immunol. 2018; 142(5): 1415-1422. doi: 10.1016/j.jaci.2018.09.011</mixed-citation><mixed-citation xml:lang="en">Nassenstein C, Krasteva-Christ G, Renz H. New aspects of neuroinflammation and neuroimmune crosstalk in the airways. J Allergy Clin Immunol. 2018; 142(5): 1415-1422. doi: 10.1016/j.jaci.2018.09.011</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta P, Sil S, Ghosh R, Ghosh A, Ghosh T. Intracerebroventricular Aβ-induced neuroinflammation alters peripheral immune responses in rats. J Mol Neurosci. 2018; 66(4): 572-586. doi: 10.1007/s12031-018-1189-9</mixed-citation><mixed-citation xml:lang="en">Gupta P, Sil S, Ghosh R, Ghosh A, Ghosh T. Intracerebroventricular Aβ-induced neuroinflammation alters peripheral immune responses in rats. J Mol Neurosci. 2018; 66(4): 572-586. doi: 10.1007/s12031-018-1189-9</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Петрова Е.С., Колос Е.А. Современные представления о клетках периневрия: особенности происхождения, структура ифункции. Журнал эволюционной биохимии и физиологии. 2022; 58(1): 3-23. doi: 10.31857/S0044452922010053</mixed-citation><mixed-citation xml:lang="en">Petrova ES, Kolos EA. Current views on perineural cells: Unique origin, structure, functions. Journal of Evolutionary Biochemistry and Physiology. 2022; 58(1): 3-23. (In Russ.). doi: 10.31857/S0044452922010053</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Ziegelmann MJ, Farrell MR, Levine LA. Evaluation and management of chronic scrotal content pain – a common yet poorly understood condition. Rev Urol. 2019; 21(2-3): 74-84.</mixed-citation><mixed-citation xml:lang="en">Ziegelmann MJ, Farrell MR, Levine LA. Evaluation and management of chronic scrotal content pain – a common yet poorly understood condition. Rev Urol. 2019; 21(2-3): 74-84.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011; 152(3): S2-S15. doi: 10.1016/j.pain.2010.09.030</mixed-citation><mixed-citation xml:lang="en">Woolf CJ. Central sensitization: implications for the diagnosis and treatment of pain. Pain. 2011; 152(3): S2-S15. doi: 10.1016/j.pain.2010.09.030</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Downie WW, Leatham PA, Rhind VM, Wright V, Branco JA, Anderson JA. Studies with pain rating scales. Ann Rheum Dis. 1978; 37(4): 378-381. doi: 10.1136/ard.37.4.378</mixed-citation><mixed-citation xml:lang="en">Downie WW, Leatham PA, Rhind VM, Wright V, Branco JA, Anderson JA. Studies with pain rating scales. Ann Rheum Dis. 1978; 37(4): 378-381. doi: 10.1136/ard.37.4.378</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">National Institutes of Health. Warren Grant Magnuson Clinical Center. Pain intensity instruments. URL: https://acne.gr/wp-content/uploads/2016/06/PainNumericRatingScale.pdf [access date: 06.04.2022].</mixed-citation><mixed-citation xml:lang="en">National Institutes of Health. Warren Grant Magnuson Clinical Center. Pain intensity instruments. URL: https://acne.gr/wp-content/uploads/2016/06/PainNumericRatingScale.pdf [access date: 06.04.2022].</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">The Faces Pain Scale – revised. URL: iasp-pain.org/resources/faces-pain-scale-revised/ [date of access: 06.04.2022].</mixed-citation><mixed-citation xml:lang="en">The Faces Pain Scale – revised. URL: iasp-pain.org/resources/faces-pain-scale-revised/ [date of access: 06.04.2022].</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Strebel RT, Schmidt C, Beatrice J, Sulser T. Chronic scrotal pain syndrome (CSPS): The widespread use of antibiotics is not justified. Andrology. 2013; 1(1): 155-159. doi: 10.1111/j.20472927.2012.00017.x</mixed-citation><mixed-citation xml:lang="en">Strebel RT, Schmidt C, Beatrice J, Sulser T. Chronic scrotal pain syndrome (CSPS): The widespread use of antibiotics is not justified. Andrology. 2013; 1(1): 155-159. doi: 10.1111/j.20472927.2012.00017.x</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Sansone RA, Sansone LA. Pain, pain, go away: Antidepressants and pain management. Psychiatry (Edgmont). 2008; 5(12): 16-19.</mixed-citation><mixed-citation xml:lang="en">Sansone RA, Sansone LA. Pain, pain, go away: Antidepressants and pain management. Psychiatry (Edgmont). 2008; 5(12): 16-19.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Calixte N, Brahmbhatt J, Parekattil S. Chronic testicular and groin pain: Pathway to relief. Curr Urol Rep. 2017; 18(10): 83. doi: 10.1007/s11934-017-0722-7</mixed-citation><mixed-citation xml:lang="en">Calixte N, Brahmbhatt J, Parekattil S. Chronic testicular and groin pain: Pathway to relief. Curr Urol Rep. 2017; 18(10): 83. doi: 10.1007/s11934-017-0722-7</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Dockray J, Aljumaily A, Lau S, Jarvi KA, Randomized A. Double-blind, controlled trial shows that onabotulinum toxin a nerve blocks do not provide improved pain control in men with chronic scrotal pain. J Urol. 2020; 203(4): 767-772. doi: 10.1097/JU.0000000000000658</mixed-citation><mixed-citation xml:lang="en">Dockray J, Aljumaily A, Lau S, Jarvi KA, Randomized A. Double-blind, controlled trial shows that onabotulinum toxin a nerve blocks do not provide improved pain control in men with chronic scrotal pain. J Urol. 2020; 203(4): 767-772. doi: 10.1097/JU.0000000000000658</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Cui T, Terlecki R. Prevalence of relative deficiencies in testosterone and vitamin B12 among patients referred for chronic orchialgia: Implications for management. Am J Mens Health. 2018; 12(3): 608-611. doi: 10.1177/1557988316642723</mixed-citation><mixed-citation xml:lang="en">Cui T, Terlecki R. Prevalence of relative deficiencies in testosterone and vitamin B12 among patients referred for chronic orchialgia: Implications for management. Am J Mens Health. 2018; 12(3): 608-611. doi: 10.1177/1557988316642723</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Starke NR, Costabile RA. Medical management of chronic orchialgia. Transl Androl Urol. 2017; 6(1): S48-S50. doi: 10.21037/tau.2017.05.18</mixed-citation><mixed-citation xml:lang="en">Starke NR, Costabile RA. Medical management of chronic orchialgia. Transl Androl Urol. 2017; 6(1): S48-S50. doi: 10.21037/tau.2017.05.18</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Parekattil SJ, Gudeloglu A, Brahmbhatt JV, Priola KB, Vieweg J, Allan RW. Trifecta nerve complex: Potential anatomical basis for microsurgical denervation of the spermatic cord for chronic orchialgia. J Urol. 2013; 190(1): 265-270. doi: 10.1016/j.juro.2013.01.045</mixed-citation><mixed-citation xml:lang="en">Parekattil SJ, Gudeloglu A, Brahmbhatt JV, Priola KB, Vieweg J, Allan RW. Trifecta nerve complex: Potential anatomical basis for microsurgical denervation of the spermatic cord for chronic orchialgia. J Urol. 2013; 190(1): 265-270. doi: 10.1016/j.juro.2013.01.045</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Panunzio A, Tafuri A, Mazzucato G, Cerrato C, Orlando R, Pagliarulo V, et al. Botulinum toxin-a injection in chronic pelvic pain syndrome treatment: A systematic review and pooled metaanalysis. Toxins (Basel). 2022; 14(1): 25. doi: 10.3390/toxins14010025</mixed-citation><mixed-citation xml:lang="en">Panunzio A, Tafuri A, Mazzucato G, Cerrato C, Orlando R, Pagliarulo V, et al. Botulinum toxin-a injection in chronic pelvic pain syndrome treatment: A systematic review and pooled meta-analysis. Toxins (Basel). 2022; 14(1): 25. doi: 10.3390/toxins14010025</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Murthy PB, Parekh NV, Vij SC, Shoskes DA. Microscopic spermatic cord denervation for chronic orchialgia/chronic scrotal content pain: Operative outcomes and predictors of failure. Transl Androl Urol. 2020; 9(5): 1931-1936. doi: 10.21037/tau-20-561</mixed-citation><mixed-citation xml:lang="en">Murthy PB, Parekh NV, Vij SC, Shoskes DA. Microscopic spermatic cord denervation for chronic orchialgia/chronic scrotal content pain: Operative outcomes and predictors of failure. Transl Androl Urol. 2020; 9(5): 1931-1936. doi: 10.21037/tau-20-561</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Tan WP, Levine LA. Micro-denervation of the spermatic cord for post-vasectomy pain management. Sex Med Rev. 2018; 6(2): 328-334. doi: 10.1016/j.sxmr.2017.06.002</mixed-citation><mixed-citation xml:lang="en">Tan WP, Levine LA. Micro-denervation of the spermatic cord for post-vasectomy pain management. Sex Med Rev. 2018; 6(2): 328-334. doi: 10.1016/j.sxmr.2017.06.002</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Calixte N, Kartal IG, Tojuola B, Gudeloglu A, Etafy M, Brahmbhatt JV, et al. Salvage ultrasound-guided targeted cryoablation of the perispermatic cord for persistent chronic scrotal content pain after microsurgical denervation of the spermatic cord. Urology. 2019; 130: 181-185. doi: 10.1016/j.urology.2019.04.027</mixed-citation><mixed-citation xml:lang="en">Calixte N, Kartal IG, Tojuola B, Gudeloglu A, Etafy M, Brahmbhatt JV, et al. Salvage ultrasound-guided targeted cryoablation of the perispermatic cord for persistent chronic scrotal content pain after microsurgical denervation of the spermatic cord. Urology. 2019; 130: 181-185. doi: 10.1016/j.urology.2019.04.027</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Calixte N, Tojuola B, Kartal I, Gudeloglu A, Hirsch M, Etafy M, et al. Targeted robotic assisted microsurgical denervation of the spermatic cord for the treatment of chronic orchialgia or groin pain: A single center, large series review. J Urol. 2018; 199(4): 1015-1022. doi: 10.1016/j.juro.2017.10.030</mixed-citation><mixed-citation xml:lang="en">Calixte N, Tojuola B, Kartal I, Gudeloglu A, Hirsch M, Etafy M, et al. Targeted robotic assisted microsurgical denervation of the spermatic cord for the treatment of chronic orchialgia or groin pain: A single center, large series review. J Urol. 2018; 199(4): 1015-1022. doi: 10.1016/j.juro.2017.10.030</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Siu W, Ohl DA, Schuster TG. Long-term follow-up after epididymectomy for chronic epididymal pain. Urology. 2007; 70(2): 333-335. doi: 10.1016/j.urology.2007.03.080</mixed-citation><mixed-citation xml:lang="en">Siu W, Ohl DA, Schuster TG. Long-term follow-up after epididymectomy for chronic epididymal pain. Urology. 2007; 70(2): 333-335. doi: 10.1016/j.urology.2007.03.080</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Cadeddu JA, Bishoff JT, Chan DY, Moore RG, Kavoussi LR, Jarrett TW. Laparoscopic testicular denervation for chronic orchalgia. J Urol. 1999; 162(3 Pt 1): 733-735. doi: 10.1097/00005392199909010-00028</mixed-citation><mixed-citation xml:lang="en">Cadeddu JA, Bishoff JT, Chan DY, Moore RG, Kavoussi LR, Jarrett TW. Laparoscopic testicular denervation for chronic orchalgia. J Urol. 1999; 162(3 Pt 1): 733-735. doi: 10.1097/00005392199909010-00028</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Sharlip ID, Belker AM, Honig S, Labrecque M, Marmar JL, Ross LS, et al. Vasectomy: AUA guideline. J Urol. 2012; 188(6): 24822491. doi: 10.1016/j.juro.2012.09.080</mixed-citation><mixed-citation xml:lang="en">Sharlip ID, Belker AM, Honig S, Labrecque M, Marmar JL, Ross LS, et al. Vasectomy: AUA guideline. J Urol. 2012; 188(6): 24822491. doi: 10.1016/j.juro.2012.09.080</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Smith-Harrison LI, Smith RP. Vasectomy reversal for postvasectomy pain syndrome. Transl Androl Urol. 2017; 6(1): S10-S13. doi: 10.21037/tau.2017.04.37</mixed-citation><mixed-citation xml:lang="en">Smith-Harrison LI, Smith RP. Vasectomy reversal for postvasectomy pain syndrome. Transl Androl Urol. 2017; 6(1): S10-S13. doi: 10.21037/tau.2017.04.37</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
