<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">actabiomedica</journal-id><journal-title-group><journal-title xml:lang="ru">Acta Biomedica Scientifica</journal-title><trans-title-group xml:lang="en"><trans-title>Acta Biomedica Scientifica</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2541-9420</issn><issn pub-type="epub">2587-9596</issn><publisher><publisher-name>Scientific Centre for Family Health and Human Reproduction Problems</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.29413/ABS.2022-7.2.27</article-id><article-id custom-type="elpub" pub-id-type="custom">actabiomedica-3449</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ХИРУРГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>SURGERY</subject></subj-group></article-categories><title-group><article-title>Оценка качества жизни пациентов с ахалазией кардии после видеоэндоскопической кардиомиотомии по Геллеру с фундопликацией по Дору</article-title><trans-title-group xml:lang="en"><trans-title>Assessment of the quality of life of patients with achalasia of the cardia after videoendoscopic Heller cardiomyotomy with Dor fundoplication</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0628-8688</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цеймах</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tseymakh</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор, заведующий кафедрой общей хирургии, оперативной хирургии и топографической анатомии</p><p>656038, г. Барнаул, ул. Ленина, 40</p></bio><bio xml:lang="en"><p>Dr. Sc. (Med.), Professor, Head of the Department of General Surgery, Operative Surgery and Topographic Anatomy</p><p>Lenina str. 40, Barnaul 656038</p></bio><email xlink:type="simple">yea220257@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9314-7180</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ганков</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gankov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, доцент, профессор кафедры общей хирургии, оперативной хирургии и топографической анатомии</p><p>656038, г. Барнаул, ул. Ленина, 40</p></bio><bio xml:lang="en"><p>Dr. Sc. (Med.), Professor at the Department of General Surgery, Operative Surgery and Topographic Anatomy</p><p>Lenina str. 40, Barnaul 656038</p></bio><email xlink:type="simple">viktorgankov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8599-825X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Багдасарян</surname><given-names>Г. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Bagdasaryan</surname><given-names>G. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент кафедры общей хирургии, оперативной хирургии и топографической анатомии</p><p>656038, г. Барнаул, ул. Ленина, 40</p></bio><bio xml:lang="en"><p>Teaching Assistant at the Department of General Surgery, Operative Surgery and Topographic Anatomy</p><p>Lenina str. 40, Barnaul 656038</p></bio><email xlink:type="simple">ms.bag1973@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3113-8734</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андреасян</surname><given-names>А. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Andreasyan</surname><given-names>A. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, доцент, доцент кафедры общей хирургии, оперативной хирургии и топографической анатомии</p><p>656038, г. Барнаул, ул. Ленина, 40</p></bio><bio xml:lang="en"><p>Cand. Sc. (Med.), Docent, Associate Professor at the Department of General Surgery, Operative Surgery and Topographic Anatomy</p><p>Lenina str. 40, Barnaul 656038</p></bio><email xlink:type="simple">andreasyanarm@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5542-9707</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Масликова</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Maslikova</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, доцент кафедры общей хирургии, оперативной хирургии и топографической анатомии</p><p>656038, г. Барнаул, ул. Ленина, 40</p></bio><bio xml:lang="en"><p>Cand.  Sc.  (Med.), Associate Professor at the Department of General Surgery, Operative Surgery and Topographic Anatomy</p><p>Lenina str. 40, Barnaul 656038</p></bio><email xlink:type="simple">maslikova18@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Алтайский государственный медицинский университет» Минздрава России</institution></aff><aff xml:lang="en"><institution>Altai State Medical University</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>25</day><month>05</month><year>2022</year></pub-date><volume>7</volume><issue>2</issue><fpage>272</fpage><lpage>281</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Цеймах Е.А., Ганков В.А., Багдасарян Г.И., Андреасян А.Р., Масликова С.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Цеймах Е.А., Ганков В.А., Багдасарян Г.И., Андреасян А.Р., Масликова С.А.</copyright-holder><copyright-holder xml:lang="en">Tseymakh E.A., Gankov V.A., Bagdasaryan G.I., Andreasyan A.R., Maslikova S.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.actabiomedica.ru/jour/article/view/3449">https://www.actabiomedica.ru/jour/article/view/3449</self-uri><abstract><sec><title>Обоснование</title><p>Обоснование. Ведущим симптомом ахалазии кардии (АК) является дисфагия, наряду с другими симптомами существенно влияющая на качество жизни пациентов.</p></sec><sec><title>Цель исследования</title><p>Цель исследования: по результатам анкетирования пациентов с помощью специальных и общих опросников и проведением специальных методов исследования замыкательной функции кардии оценить качество жизни больных со 2–4-й стадиями АК после видеолапароскопической эзофагокардиомиотомии по Геллеру с передней гемиэзофагофундопликацией по Дору.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Основу работы составил анализ результатов эзофагокардиомиотомии по Геллеру с передней гемиэзофагофундопликацией по Дору 106 пациентов со 2–4-й стадиями АК. Послеоперационный период наблюдения составил в среднем 2 ± 0,4 года. В до- и послеоперационном периодах изучены результаты рентгеноскопии пищевода и желудка, манометрии пищевода и пищеводно-желудочного перехода, также применялись три опросника (шкала Экардта, опросники GIQLI и SF-36).</p></sec><sec><title>Результаты</title><p>Результаты. Анализ полученных данных показал, что клинические проявления заболевания в послеоперационном периоде уменьшились у всех пациентов со 2–4-й стадиями АК, результаты у пациентов со 2-й стадией были лучше, чем у пациентов с 3-й и 4-й стадиями (p &lt; 0,05).</p></sec><sec><title>Заключение</title><p>Заключение. Видеоэндоскопическая эзофагомиотомия по Геллеру с передней фундопликацией по Дору статистически значимо способствует уменьшению выраженности клинических проявлений АК и улучшению качества жизни у больных со 2–4-й стадиями АК, вследствие чего следует рекомендовать больным операцию уже при 2-й стадии и органосохраняющую операцию – при 4-й стадии заболевания.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. The leading symptom of achalasia of cardia (AC) is dysphagia, along with other symptoms significantly affecting the quality of life of patients.</p></sec><sec><title>The aim</title><p>The aim. Based on the results of questioning patients using special and general questionnaires and using special methods for studying the closing function of the cardia, to evaluate the quality of life of patients with stages 2–4 of AC after video-laparoscopic esophagocardiomyotomy according to Heller with anterior hemiasophagofundoplication according to Dor.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The basis of the work was the analysis of the results of esophagocardiomyotomy according to Heller with anterior hemiesophagofundoplication according to Dor in 106 patients with stages 2–4 of AC. The postoperative follow-up period averaged 2 ± 0.4 years. In the pre- and postoperative periods, the results of fluoroscopy of the esophagus and stomach, manometry of the esophagus and the esophageal-gastric junction were studied, and three questionnaires were used (Eckhardt scale, GIQLI questionnaire and SF-36).</p></sec><sec><title>Results</title><p>Results. Analysis of the data obtained showed that the clinical manifestations of the disease in the postoperative period decreased in all patients with stages 2–4 of AC, the results in patients with stage 2 were better than in patients with stages 3 and 4 (p &lt; 0.05). The results of fluoroscopy of the esophagus and stomach, manometry of the esophagus and the esophagogastric junction showed improvement in the postoperative period in patients at all stages of the disease, the results of patients with stage 4 were worse compared with stages 2 and 3 (p &lt; 0.05).</p></sec><sec><title>Conclusion</title><p>Conclusion. Videoendoscopic esophagomyotomy according to Heller with anterior fundoplication according to Dor significantly reduces the severity of clinical manifestations of AC and improves the quality of life in patients with stages 2–4 of AC, as a result of which surgery should be recommended to patients already at stage 2 and organ-preserving surgery at stage 4 of the disease.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ахалазия кардии</kwd><kwd>дисфагия</kwd><kwd>видеолапароскопическая кардиомиотомия по Геллеру</kwd><kwd>качество жизни</kwd></kwd-group><kwd-group xml:lang="en"><kwd>achalasia of the cardia</kwd><kwd>dysphagia</kwd><kwd>laparoscopic Heller myotomy</kwd><kwd>quality of life</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Richter JE. Achalasia – an update. JNeurogastroenterol Motil. 2010; 16(3): 232-242. doi: 10.5056/jnm.2010.16.3.232</mixed-citation><mixed-citation xml:lang="en">Richter JE. Achalasia – an update. JNeurogastroenterol Motil. 2010; 16(3): 232-242. doi: 10.5056/jnm.2010.16.3.232</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Spechler SJ. Clinical manifestation and diagnosis of achalasia. In: Wellesley R. (ed.). UpToDate in gastroenterology and hepatology. UpToDate Inc.; 2008.</mixed-citation><mixed-citation xml:lang="en">Spechler SJ. Clinical manifestation and diagnosis of achalasia. In: Wellesley R. (ed.). UpToDate in gastroenterology and hepatology. UpToDate Inc.; 2008.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Vaezi MF, Pandolfino JE, Vela MF. ACG clinical guideline: Diagnosis and management of achalasia. Am J Gastroenterol. 2013; 108(8): 1238-1249. doi: 10.1038/ajg.2013.196</mixed-citation><mixed-citation xml:lang="en">Vaezi  MF, Pandolfino  JE, Vela  MF. ACG clinical guideline: Diagnosis and management of achalasia. Am J Gastroenterol. 2013; 108(8): 1238–1249. doi: 10.1038/ajg.2013.196</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Inoue H., Minami H., Kobayashi Y., Sato Y, Kaga M, Suzuki M, et al. Peroral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy. 2010; 42(4): 265-271. doi: 10.1055/s-0029-1244080</mixed-citation><mixed-citation xml:lang="en">Inoue H., Minami H., Kobayashi Y., Sato Y, Kaga M, Suzuki M, et al. Peroral endoscopic myotomy (POEM) for esophageal achalasia. Endoscopy. 2010; 42(4): 265-271. doi: 10.1055/s-0029-1244080</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Oude Nijhuis RAB, Zaninotto G, Roman S, Boeckxstaens GE, Fockens P, Langendam MW, et al. European guideline on achalasia: United European Gastroenterology and European Society of Neurogastroenterology and Motility recommendations. United European GastroenterolJ. 2020; 8(1): 13-33. doi: 10.1177/2050640620903213</mixed-citation><mixed-citation xml:lang="en">Oude Nijhuis  RAB, Zaninotto  G, Roman  S, Boeckxstaens GE, Fockens P, Langendam MW, et al. European guideline on achalasia: United European Gastroenterology and European Society of Neurogastroenterology and Motility recommendations. United European Gastroenterol J. 2020; 8(1): 13-33. doi: 10.1177/2050640620903213</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Анипченко А.Н., Аллахвердян А.С. Диагностика и лечение ахалазии кардии: Клиническая лекция. Московский хирургический журнал. 2018; 4: 5-13. doi: 10.17238/issn2072-3180.2018.4.5-13</mixed-citation><mixed-citation xml:lang="en">Anipchenko AN, Allahverdyan AS. Diagnosis and treatment of achalasia of cardia: Clinical lecture. Moscow Surgical Journal. 2018; 4; 5-13. (In Russ.). doi: 10.17238/issn2072-3180.2018.4.5-13</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Низамходжаев З.М., Лигай Р.Е., Цой А.О., Шагазатов Д.Б., Хаджибаев Ж.А., Нигматуллин Э.И., и др. Опыт применения миниинвазивных методов лечения у больных с запущенными стадиями ахалазии кардии. Вопросы реконструктивной и пластической хирургии. 2020; 23(2): 49-57. doi: 10.17223/1814147/73/06</mixed-citation><mixed-citation xml:lang="en">Nizamkhodjaev  ZM, Ligay  RE, Tsoy  AO, Shagazatov  DB, Khadjibaev ZhA, Nigmatullin EI, et al. Experience of application of minimally invasive methods of treatment patients with launched stages of achalasia. Issues of Reconstructive and Plastic Surgery. 2020; 23(2); 49-57. (In Russ.). doi: 10.17223/1814147/73/06</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ручкин Д.В. Оконская Д., Ян М. Эзофагэктомия как способ радикального лечения ахалазии кардии терминальной стадии. Вестник экспериментальной и клинической хирургии. 2019; 12(1): 62-70. doi: 10.18499/2070-478X-2019-12-1-62-70</mixed-citation><mixed-citation xml:lang="en">Ruchkin  DV, Okonskaya  D, Yan  M. Esophagectomy as a method of radical treatment of end-stage cardia achalasia. Vestnik of Experimental and Clinical Surgery. 2019; 12(1): 62-70. (In Russ.). doi: 10.18499/2070-478X-2019-12-1-62-70</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Watson TJ. Esophagectomy for end-stage achalasia. World J Surg. 2015; 39(7): 1634-1641. doi: 10.1007/s00268-015-3012-x</mixed-citation><mixed-citation xml:lang="en">Watson TJ. Esophagectomy for end-stage achalasia. World J Surg. 2015; 39(7): 1634-1641. doi: 10.1007/s00268-015-3012-x</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Оскретков В.И., Ганков В.А., Балацкий Д.В., Гурьянов А.А., Андреасян А.Р., Овсепян М.А. Эндохирургия функциональных нарушений замыкательной функции кардии. Сибирское медицинское обозрение. 2017; 3(105): 31-37. doi: 10.20333/2500136-2017-3-31-37</mixed-citation><mixed-citation xml:lang="en">Oskretkov VI, Gankov VA, Balatskiy DV, Guryanov AA, Andreasyan AR, Ovsepyan MA. Endosurgery of functional disorders in  closing function of the cardia. Siberian Medical Review. 2017; 3(105): 31-37. (In Russ.). doi: 10.20333/2500136-2017-3-31-37</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Scott PD, Harold KL, Heniford RBT, Jaroszewski DE. Results of laparoscopic Heller myotomy for extreme megaesophagus: An alternative to esophagectomy. Surg Laparosc Endosc Percutan Tech. 2009; 19(3): 198-200. doi: 10.1097/SLE.0b013e3181a6dd58</mixed-citation><mixed-citation xml:lang="en">Scott PD, Harold KL, Heniford RBT, Jaroszewski DE. Results of laparoscopic Heller myotomy for extreme megaesophagus: An alternative to esophagectomy. Surg Laparosc Endosc Percutan Tech. 2009; 19(3): 198-200. doi: 10.1097/SLE.0b013e3181a6dd58</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Бурмистров М.В., Сигал Е.И., Шарапов Т.Л., Иванов А.И., Бакиров М.Р. Отдалённые результаты эндохирургического лечения ахалазии кардии. Эндоскопическая хирургия. 2016; 22(5); 3-6. doi: 10.17116/endoskop20162253-5</mixed-citation><mixed-citation xml:lang="en">Burmistrov  MV, Sigal  EI, Sharapov TL, Ivanov  AI, Bakirov MR. Long-term results of endosurgical treatment of achalasia. Endoscopic surgery. 2016; 22(5): 3-6. (In Russ.). doi: 10.32000/2072-1757-2018-7-15-20</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ross D, Richter J, Velanovich V. Health-related quality of life and physiological measurements in achalasia. Dis Esophagus. 2016; 30(2): 1-5. doi: 10.1111/dote.12494</mixed-citation><mixed-citation xml:lang="en">Ross D, Richter J, Velanovich V. Health-related quality of life and physiological measurements in achalasia. Dis Esophagus. 2016; 30(2): 1-5. doi: 10.1111/dote.12494</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
